Gastric adaptation to injury by repeated doses of aspirin strengthens mucosal defence against subsequent exposure to various strong irritants in rats.

Cytoprotection by prostaglandins

1979 • 1,076 citations

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

1990 • 563 citations

Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins

1983 • 492 citations

Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells

1990 • 465 citations

Nonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models

1991 • 364 citations

Gastric adaptation occurs with aspirin administration in man

1983 • 207 citations

Gastric adaptation

1988 • 176 citations

Nonsteroidal Antiinflammatory Drug-Induced Ulcers: Management by Traditional Therapies

1989 • 148 citations

Transforming Growth Factor Alpha and Epidermal Growth Factor in Protection and Healing of Gastric Mucosal Injury

1992 • 144 citations

Role of locally generated prostaglandins in adaptive gastric cytoprotection

1982 • 141 citations

Increased production of transforming growth factor α following acute gastric injury

1992 • 133 citations

Hemodynamic effects of acute changes in intra-abdominal pressure in patients with cirrhosis

1993 • 129 citations

Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract.

1992 • 107 citations

Effect of Chronic Aspirin Ingestion on Epithelial Proliferation in Rat Fundus, Antrum, and Duodenum

1982 • 94 citations

PROSTAGLANDINS, NSAIDs, AND CYTOPROTECTION

1992 • 90 citations

Adaptation of the gastric mucosa to repeated administration of aspirin in the rat

1973 • 89 citations

Mucosal adaptation to indomethacin induced gastric damage in man--studies on morphology, blood flow, and prostaglandin E2 metabolism.

1992 • 78 citations

Proliferating cell nuclear antigen in oesophageal diseases; correlation with transforming growth factor alpha expression.

1992 • 70 citations

Non-Steroidal Anti-Inflammatory Drug Gastropathy and Cytoprotection: Pathogenesis and Mechanisms Re-examined

1992 • 63 citations

Role of salivary glands and epidermal growth factor (EGF) in gastric secretion and mucosal integrity in rats exposed to stress

1991 • 63 citations

Role of gastric blood flow, neutrophil infiltration, and mucosal cell proliferation in gastric adaptation to aspirin in the rat.

1994 • 60 citations

Gastric Mucosal Resistance to a Repeated Ethanol Insult

1985 • 52 citations

Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats

1993 • 44 citations

The effects of indomethacin on gastroduodenal morphology and mucosal pH gradient in the healthy human stomach

1990 • 42 citations

Gastric Adaptation to Nonsteroidal Anti-Inflammatory Drugs in Man

1992 • 37 citations

Effects of nonsteroidal anti-inflammatory drugs and misoprostol on gastroduodenal epithelial proliferation in arthritis

1992 • 33 citations

Epidermal Growth Factor Content of Submandibular Glands is Increased in Rats with Experimentally Induced Gastric Lesions

1988 • 30 citations

Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity

1991 • 29 citations

Adaptation of the Gastric Mucosa to Stress

1992 • 22 citations

Gastric Mucosal Protection Induced by Restraint and Water-Immersion Stress in Rats

1990 • 22 citations

The induction of gastric mucosal tolerance to alcohol by chronic administration.

1980 • 21 citations

Adaptation of rat gastric mucosa to repeated doses of non‐salicylate non‐steroidal anti‐inflammatory drugs

1992 • 21 citations

In Vitro Adaptive Cytoprotection in Gastric Cells Isolated from Rat Stomach

1990 • 18 citations

Gastric Adaptation: Basic and Clinical Aspects

1994 • 17 citations

Evidence of “cross-stressor” - induced adaptive gastric cytoprotection

1987 • 16 citations

Effects of chronic superficial injury on the rat gastric mucosa

1992 • 15 citations

Role of neurophils and mucosal blood flow in gastric adaptation to aspirin

1994 • 14 citations

Transforming growth factor-alpha binds to the epidermal growth factor receptor in gastric mucosa.

1991 • 13 citations

Gastroprotective activity and receptor expression of transforming growth factor alpha, epidermal growth factor and basic fibroblast growth factor in the rat stomach

1994 • 7 citations

Transforming growth factor-alpha binds to the epidermal growth factor receptor in gastric mucosa.

1991 • 3 citations