Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish

Biological behavior of malignant melanoma cells correlated to their survival in vivo.

1975 • 586 citations

Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases

1997 • 529 citations

Small molecule developmental screens reveal the logic and timing of vertebrate development

2000 • 483 citations

Zebrafish pigmentation mutations and the processes of neural crest development

1996 • 442 citations

Chemical genetics resulting from a passion for synthetic organic chemistry

1998 • 405 citations

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

1999 • 267 citations

PERSPECTIVE

2003 • 245 citations

Restriction of neural crest cell fate in the trunk of the embryonic zebrafish

1994 • 234 citations

Melanosomal pH Controls Rate of Melanogenesis, Eumelanin/Phaeomelanin Ratio and Melanosome Maturation in Melanocytes and Melanoma Cells

2001 • 230 citations

Zebrafish-Based Small Molecule Discovery

2003 • 163 citations

Localization of melanin pigmentation in the skin with Wood's lamp

1977 • 159 citations

Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells.

1987 • 156 citations

Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway

2002 • 155 citations

Regulation of the Catalytic Activity of Preexisting Tyrosinase in Black and Caucasian Human Melanocyte Cell Cultures

2001 • 151 citations

Facilitated Forward Chemical Genetics Using a Tagged Triazine Library and Zebrafish Embryo Screening

2003 • 144 citations

Pink-eyed Dilution Protein Controls the Processing of Tyrosinase

2002 • 130 citations

The Pteridine Pathway in Zebrafish: Regulation and Specification during the Determination of Neural Crest Cell‐Fate

2003 • 124 citations

A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening

2002 • 123 citations

Complementation of Hypopigmentation in p-Mutant (Pink-Eyed Dilution) Mouse Melanocytes by Normal Human P cDNA, and Defective Complementation by OCA2 Mutant Sequences

1997 • 123 citations

Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia

2003 • 107 citations

The relationship between Na+/H+ exchanger expression and tyrosinase activity in human melanocytes

2004 • 98 citations

7-Substituted 5-Amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A_2AAdenosine Receptor Antagonists: A Study on the Importance of Modifications at the Side Chain on the Activity and Solubility

2001 • 92 citations

Combinatorial chemistry : synthesis, analysis, screening

1999 • 81 citations

Discovery of Estrogen Sulfotransferase Inhibitors from a Purine Library Screen

2001 • 76 citations

Purine-Based Inhibitors of Inositol-1,4,5-trisphosphate-3-kinase

2002 • 68 citations

Using small molecules to study big questions in cellular microbiology

2002 • 53 citations

Identification of Compounds that Bind Mitochondrial F1F0 ATPase by Screening a Triazine Library for Correction of Albinism

2004 • 50 citations

Functional Genomics Tools for the Analysis of Zebrafish Pigment

2004 • 47 citations

Design, Synthesis, and Biological Activities of Classical N-{4-[2-(2-Amino-4-ethylpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-<scp>l</scp>-glutamic Acid and Its 6-Methyl Derivative as Potential Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase and as Potential Antitumor Agents

2003 • 38 citations

Tagged library approach to chemical genomics and proteomics

2003 • 36 citations

Correction of Defective Early Tyrosinase Processing by Bafilomycin A1 and Monensin in Pink‐Eyed Dilution Melanocytes

2004 • 27 citations

Strategies for Facilitated Forward Chemical Genetics

2004 • 27 citations

Combinatorial libraries and biological discovery

2001 • 20 citations

Sweet surrender to chemical genetics

2002 • 19 citations

Fortnightly review: Cosmetic surgery

1999 • 15 citations

Deleted Work

1955 • 0 citations