Mutations of theparaSodium Channel ofDrosophila melanogasterIdentify Putative Binding Sites for Pyrethroids

From Ionic Currents to Molecular Mechanisms

2000 • 2,039 citations

The Voltage Sensor in Voltage-Dependent Ion Channels

2000 • 854 citations

Identification of mutations in the houseflypara-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides

1996 • 531 citations

Molecular analysis of the para locus, a sodium channel gene in Drosophila

1989 • 501 citations

Neurotoxic Actions of Pyrethroid Insecticides

1989 • 471 citations

Neuronal Ion Channels as the Target Sites of Insecticides

1996 • 421 citations

Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit

1996 • 410 citations

Nerve membrane Na+ channels as targets of insecticides

1992 • 243 citations

Molecular kinetics of voltage-dependent Na+ channels

1991 • 243 citations

Cloning and functional analysis of tipE, a novel membrane protein that enhances drosophila para sodium channel function

1995 • 208 citations

Functional Expression ofDrosophila paraSodium Channels

1997 • 208 citations

The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels

2001 • 195 citations

A Critical Role for the S4-S5 Intracellular Loop in Domain IV of the Sodium Channel α-Subunit in Fast Inactivation

1998 • 184 citations

Molecular Analysis of kdr-like Resistance in Permethrin-Resistant Strains of Head Lice, Pediculus capitis

2000 • 179 citations

Impaired slow inactivation in mutant sodium channels

1996 • 179 citations

Differential mechanism of action of the pyrethroid tetramethrin on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.

1994 • 166 citations

Voltage-dependent gating of sodium channels: correlating structure and function

1986 • 160 citations

Toxicological, Electrophysiological, and Molecular Characterisation of Knockdown Resistance to Pyrethroid Insecticides in the Diamondback Moth,Plutella xylostella(L.)

1998 • 156 citations

Activation ofDrosophilaSodium Channels Promotes Modification by Deltamethrin

2000 • 155 citations

The L1014F Point Mutation in the House Fly Vssc1 Sodium Channel Confers Knockdown Resistance to Pyrethroids

1997 • 116 citations

N-type inactivation and the S4-S5 region of the Shaker K+ channel.

1996 • 107 citations

Mutations in the house fly Vssc1 sodium channel gene associated with super-kdr resistance abolish the pyrethroid sensitivity of Vssc1/tipE sodium channels expressed in Xenopus oocytes

1999 • 104 citations

Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expressed channels to deltamethrin

2002 • 104 citations

Structural Models of the Transmembrane Region of Voltage-Gated and Other K+Channels in Open, Closed, and Inactivated Conformations

1998 • 102 citations

REGULATION OF SULPHATION AND GLUTATHIONE CONJUGATION OF ACETAMINOPHEN IN ISOLATED RAT HEPATOCYTES

1996 • 95 citations

Pyrethroid receptor in the insect sodium channel: alteration of its properties in pyrethroid-resistant flies

1989 • 86 citations

A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides

2000 • 79 citations

Altered properties of neuronal sodium channels associated with genetic resistance to pyrethroids.

1999 • 59 citations

Functional analysis of a rat sodium channel carrying a mutation for insect knock‐down resistance (kdr) to pyrethroids

1997 • 51 citations

Kinetics of modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by tetramethrin and deltamethrin.

2001 • 48 citations

A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action.

2001 • 45 citations

Conversation between Voltage Sensors and Gates of Ion Channels

2000 • 42 citations

Electrophysiological comparison of insecticide and alkaloid agonists of Na channels.

1987 • 38 citations

Immobilization of sodium channel gating charge in crayfish giant axons by the insecticide fenvalerate.

1993 • 36 citations

Point Mutations in Homology Domain II Modify the Sensitivity of Rat Nav1.8 Sodium Channels to the Pyrethroid Insecticide Cismethrin

2001 • 33 citations

Three-Dimensional Structure of the S4–S5 Segment of the Shaker Potassium Channel

2002 • 25 citations

Chemical modulation of sodium channels

1998 • 7 citations