Prostacyclin therapies for the treatment of pulmonary arterial hypertension

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

A Comparison of Continuous Intravenous Epoprostenol (Prostacyclin) with Conventional Therapy for Primary Pulmonary Hypertension

1996 • 2,590 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

Inhaled Iloprost for Severe Pulmonary Hypertension

2002 • 1,760 citations

Long-term intravenous epoprostenol infusion in primary pulmonary hypertension

2002 • 1,383 citations

Continuous Subcutaneous Infusion of Treprostinil, a Prostacyclin Analogue, in Patients with Pulmonary Arterial Hypertension

2002 • 1,382 citations

Survival in Primary Pulmonary Hypertension

2002 • 1,192 citations

Continuous Intravenous Epoprostenol for Pulmonary Hypertension Due to the Scleroderma Spectrum of Disease

2000 • 1,051 citations

Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology.

2004 • 1,041 citations

Medical Therapy For Pulmonary Arterial Hypertension

2004 • 853 citations

Prostacyclin Synthase Expression Is Decreased in Lungs from Patients with Severe Pulmonary Hypertension

1999 • 788 citations

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death‐dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

2001 • 776 citations

A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST)

1997 • 658 citations

Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial

2002 • 639 citations

Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2

2004 • 632 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

Beraprost therapy for pulmonary arterial hypertension

2003 • 627 citations

Randomized Study of Adding Inhaled Iloprost to Existing Bosentan in Pulmonary Arterial Hypertension

2006 • 622 citations

Inflammation in pulmonary arterial hypertension

2003 • 599 citations

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

2000 • 545 citations

Long-Term Prostacyclin for Pulmonary Hypertension With Associated Congenital Heart Defects

1999 • 510 citations

Combination Therapy with Oral Sildenafil and Inhaled Iloprost for Severe Pulmonary Hypertension

2002 • 507 citations

Littérature commentée

1996 • 431 citations

Medical Therapy for Pulmonary Arterial Hypertension

2007 • 422 citations

Inhaled Prostacyclin and Iloprost in Severe Pulmonary Hypertension Secondary to Lung Fibrosis

1999 • 399 citations

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer

2000 • 396 citations

Aerosolized Prostacyclin and Iloprost in Severe Pulmonary Hypertension

1996 • 385 citations

Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure

2002 • 372 citations

Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension

2003 • 360 citations

Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil

2006 • 329 citations

Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome.

1996 • 328 citations

LONG-TERM TREATMENT OF PRIMARY PULMONARY HYPERTENSION WITH CONTINUOUS INTRAVENOUS EPOPROSTENOL (PROSTACYCLIN)

1984 • 319 citations

Prognostic Factors for Survival in Human Immunodeficiency Virus–associated Pulmonary Arterial Hypertension

2003 • 318 citations

Prostacyclin-induced acute pulmonary vasodilation in primary pulmonary hypertension.

1982 • 314 citations

Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension

2006 • 291 citations

Safety and Efficacy of IV Treprostinil for Pulmonary Arterial Hypertension

2006 • 290 citations

Aerosolised prostacyclin in adult respiratory distress syndrome

1993 • 289 citations

Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ

1998 • 281 citations

Inhaled Iloprost To Treat Severe Pulmonary Hypertension: An Uncontrolled Trial

2000 • 281 citations

Outcome in 91 Consecutive Patients with Pulmonary Arterial Hypertension Receiving Epoprostenol

2003 • 259 citations

Treprostinil, a Prostacyclin Analogue, in Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

2004 • 257 citations

Nuclear localization of prostaglandin E ₂ receptors

1998 • 240 citations

Differential Effects of Stable Prostacyclin Analogs on Smooth Muscle Proliferation and Cyclic AMP Generation in Human Pulmonary Artery

2002 • 229 citations

Localization of Functional Prostaglandin E2 Receptors EP3 and EP4 in the Nuclear Envelope

1999 • 227 citations

Transition from Intravenous Epoprostenol to Intravenous Treprostinil in Pulmonary Hypertension

2005 • 222 citations

Activation of Peroxisome Proliferator-Activated Receptors (PPARs) by Their Ligands and Protein Kinase A Activators

2000 • 207 citations

Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids

2003 • 206 citations

Efficacy of Long-term Subcutaneous Treprostinil Sodium Therapy in Pulmonary Hypertension

2006 • 200 citations

The Acute Administration of Vasodilators in Primary Pulmonary Hypertension: Experience from the National Institutes of Health Registry on Primary Pulmonary Hypertension

1989 • 188 citations

Pharmacokinetics and Steady-State Bioequivalence of Treprostinil Sodium (Remodulin®) Administered by the Intravenous and Subcutaneous Route to Normal Volunteers

2004 • 181 citations

Epoprostenol (Prostacyclin) Therapy in HIV-associated Pulmonary Hypertension

2000 • 175 citations

Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension

2005 • 164 citations

Favorable Effects of Inhaled Treprostinil in Severe Pulmonary Hypertension

2006 • 148 citations

Long-term Treatment With Oral Sildenafil in Addition to Continuous IV Epoprostenol in Patients With Pulmonary Arterial Hypertension

2003 • 134 citations

Pharmacodynamics and Pharmacokinetics of Inhaled Iloprost, Aerosolized by Three Different Devices, in Severe Pulmonary Hypertension

2003 • 131 citations

Prostacyclin-dependent Apoptosis Mediated by PPARδ

2001 • 124 citations

Platelets and atherosclerosis

1964 • 123 citations

Safety and Efficacy of Inhaled Treprostinil as Add-On Therapy to Bosentan in Pulmonary Arterial Hypertension

2006 • 119 citations

Ultrasonicversusjet nebulization of iloprost in severe pulmonary hypertension

2001 • 117 citations

Short-term and long-term epoprostenol (prostacyclin) therapy in pulmonary hypertension secondary to connective tissue diseases: results of a pilot study

1999 • 116 citations

Effects of intravenous infusion of prostacyclin (PGI2) in man

1980 • 111 citations

Treatment of pulmonary hypertension with the continuous infusion of a prostacyclin analogue, iloprost

1998 • 105 citations

Efficacy and Safety of Sildenafil Added to Treprostinil in Pulmonary Hypertension

2005 • 94 citations

Prostaglandins, Platelets, And Atherosclerosi

1980 • 91 citations

Evidence-Based Clinical Practice Guidelines Hypertension: Updated ACCP Medical Therapy for Pulmonary Arterial

2007 • 88 citations

How Prostacyclin Improves Cardiac Output in Right Heart Failure in Conjunction with Pulmonary Hypertension

2007 • 82 citations

Comparative analysis of the in vivo angiogenic properties of stable prostacyclin analogs: a possible role for peroxisome proliferator-activated receptors

2003 • 82 citations

A Survey of Diagnostic Practices and the Use of Epoprostenol In Patients With Primary Pulmonary Hypertension

1998 • 79 citations

Induction of Hyaluronic Acid Synthase 2 (HAS2) in Human Vascular Smooth Muscle Cells by Vasodilatory Prostaglandins

2004 • 79 citations

Inhaled iloprost is a potent acute pulmonary vasodilator in HIV‐related severe pulmonary hypertension

2004 • 77 citations

Multiple signalling options for prostacyclin.

2003 • 60 citations

Activation of Peroxisome Proliferator-Activated Receptors (PPARs) by Their Ligands and Protein Kinase A Activators

2000 • 58 citations

Physiologic basis for the treatment of pulmonary hypertension

2001 • 56 citations

Increased neutrophil mediator release in patients with pulmonary hypertension – suppression by inhaled iloprost

2003 • 49 citations

Lipid Mediator Dysregulation in Primary Pulmonary Hypertension

1998 • 46 citations

Regulation of Peroxisome Proliferator-Activated Receptor α by Protein Kinase C

2005 • 39 citations

Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs

2007 • 39 citations

Gene expression profile of the Gs-coupled prostacyclin receptor in human vascular smooth muscle cells

2003 • 38 citations

Protein kinase A-dependent coupling of mouse prostacyclin receptors to Gi is cell-type dependent

2003 • 31 citations

Continuous intravenous iloprost to revert treatment failure of first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension

2007 • 30 citations

Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes

2007 • 25 citations

Prostacyclin in Lung Cancer

2006 • 10 citations

Prostacyclin in Lung Cancer

2006 • 6 citations