Adenoviral-Mediated Transfer of the TNF-Related Apoptosis-Inducing Ligand/Apo-2 Ligand Gene Induces Tumor Cell Apoptosis

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Cancer statistics, 1999

1999 • 3,154 citations

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

1997 • 3,081 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

1999 • 2,494 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

1999 • 2,215 citations

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

1997 • 1,212 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

1997 • 1,119 citations

Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins

1994 • 1,113 citations

Apoptosis signaling by death receptors

1998 • 976 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

1997 • 829 citations

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

1998 • 789 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

1997 • 683 citations

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

1998 • 671 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family

1997 • 634 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

TRAIL: a molecule with multiple receptors and control mechanisms

1998 • 459 citations

Binding of annexin V/placental anticoagulant protein I to platelets. Evidence for phosphatidylserine exposure in the procoagulant response of activated platelets.

1990 • 372 citations

The role of cachectin/TNF in endotoxic shock and cachexia

1988 • 335 citations

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

1998 • 331 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

Tumor necrosis factor receptor superfamily members and their ligands

1994 • 313 citations

Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes.

2000 • 292 citations

Tumor necrosis factor-related apoptosis-inducing ligand's antitumor activity in vivo is enhanced by the chemotherapeutic agent CPT-11.

1999 • 263 citations

Gene transfer of Fas ligand induces tumor regression in vivo

1997 • 247 citations

Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity

1999 • 230 citations

Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model

1999 • 170 citations

Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial

1999 • 131 citations

A family of ligands for the TNF receptor superfamily

1994 • 128 citations

Fas ligand expression in primary colon adenocarcinomas: evidence that the Fas counterattack is a prevalent mechanism of immune evasion in human colon cancer

1998 • 122 citations

Altered vascular function after adenovirus-mediated overexpression of endothelial nitric oxide synthase

1997 • 97 citations

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12

1999 • 94 citations

Treatment of Experimental Glioma by Administration of Adenoviral Vectors Expressing Fas Ligand

1999 • 83 citations

Antibodies to chemically synthesized peptides predicted from DNA sequences as probes of gene expression

1981 • 65 citations

Adenovirus-mediated expression of Fas ligand induces apoptosis of human prostate cancer cells

1999 • 58 citations

A “Stealth Effect”: Adenocarcinoma Cells Engineered to Express TRAIL Elude Tumor-Specific and Allogeneic T Cell Reactions

1999 • 51 citations

Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer

1999 • 48 citations

Eradication of primary murine fibrosarcomas and induction of systemic immunity by adenovirus-mediated interferon beta gene therapy.

1999 • 41 citations

Efficacy of adenovirus-mediated CD/5-FC and HSV-1 thymidine kinase/ganciclovir suicide gene therapies concomitant with p53 gene therapy.

1999 • 37 citations

Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors.

2000 • 34 citations

Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma

1999 • 17 citations