The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Obesity and insulin resistance

2000 • 3,076 citations

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

2005 • 2,774 citations

Metformin and reduced risk of cancer in diabetic patients

2005 • 2,278 citations

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

2005 • 1,901 citations

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

2004 • 1,710 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

2006 • 1,038 citations

Adiponectin: More Than Just Another Fat Cell Hormone?

2003 • 1,004 citations

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

2003 • 989 citations

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

2002 • 969 citations

Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

2006 • 910 citations

Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

2007 • 903 citations

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

2007 • 894 citations

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

2006 • 863 citations

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

2008 • 835 citations

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

2002 • 829 citations

mTOR, translation initiation and cancer

2006 • 592 citations

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform

1998 • 431 citations

The blooming of the French lilac

2001 • 355 citations

Metabolic Syndrome in Normal-Weight Americans

2004 • 309 citations

The Role of Insulin Receptor Isoforms and Hybrid Insulin/IGF-I Receptors in Human Cancer

2007 • 248 citations

The Underlying Basis for Obesity: Relationship to Cancer

2002 • 226 citations

Hormone responsive human breast cancer in long-term tissue culture: effect of insulin.

1976 • 222 citations

Association of Diet-Induced Hyperinsulinemia With Accelerated Growth of Prostate Cancer (LNCaP) Xenografts

2007 • 176 citations

Serum Adiponectin Concentrations and Tissue Expression of Adiponectin Receptors Are Reduced in Patients with Prostate Cancer: A Case Control Study

2007 • 175 citations

Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway

2007 • 67 citations

Do low levels of circulating adiponectin represent a biomarker or just another risk factor for the metabolic syndrome?

2006 • 59 citations

The effects of metformin on pathologic complete response (pCR) rates in diabetic breast cancer (BC) patients receiving neoadjuvant systemic therapy (NST)

2008 • 12 citations