Role of tumor cell membrane-bound serine proteases in tumor-induced target cytolysis.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples

1978 • 6,494 citations

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells

1971 • 838 citations

The Biology of Cancer Invasion and Metastasis

1978 • 819 citations

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

1973 • 779 citations

Sulfonyl Fluorides as Inhibitors of Esterases. I. Rates of Reaction with Acetylcholinesterase, α-Chymotrypsin, and Trypsin

1963 • 646 citations

[6]Isolation of rat liver plasma membrane fragments in isotonic sucrose

1974 • 609 citations

[4] Trypsinogens and trypsins of various species

1970 • 456 citations

Fibrinolysis Associated with Oncogenic Transformation

1974 • 444 citations

Ovarian plasminogen activator: Relationship to ovulation and hormonal regulation

1975 • 440 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Distribution of (Na+-K+-stimulated ATPase activity in rat intestinal mucosa

1969 • 314 citations

Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells.

1980 • 261 citations

COMPOSITION OF CELLULAR MEMBRANES IN THE PANCREAS OF THE GUINEA PIG

1971 • 248 citations

INHIBITION OF THE PROTEINASE AND ESTERASE ACTIVITIES OF TRYPSIN AND CHYMOTRYPSIN BY DIISOPROPYL FLUOROPHOSPHATE: CRYSTALLIZATION OF INHIBITED CHYMOTRYPSIN

1949 • 237 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases.

1980 • 206 citations

Effector mechanisms of cytolytically activated macrophages. I. Secretion of neutral proteases and effect of protease inhibitors.

1980 • 194 citations

Phorbol ester-induced morphological changes in transformed chick fibroblasts: Evidence for direct catalytic involvement of plasminogen activator

1979 • 168 citations

Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.

1976 • 163 citations

Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines.

1980 • 138 citations

Plasma Membranes from Cultured Muscle Cells: Isolation Procedure and Separation of Putative Plasma-Membrane Marker Enzymes

1973 • 117 citations

Serine enzymes released by cultured neoplastic cells.

1978 • 94 citations

[8] Solubilization and polyacrylamide gel electrophoresis of me mbrane enzymes with detergents

1974 • 92 citations

The solubilization and gel electrophoresis of membrane enzymes by use of detergents

1970 • 75 citations

A Cytotoxic Proteinase Isolated from Human Lymphocytes

1978 • 71 citations

Inhibition of Malignant Cell Invasion in vitro by a Proteinase Inhibitor

1973 • 55 citations

The effect of organophosphorus inhibitors, p-nitrophenol and cytochalasin B on cytotoxic killing of tumour cells by immune spleen cells, and the effect of shaking.

1972 • 53 citations

Evidence for Alkylphosphorylation of Tyrosyl Residues of Stem Bromelain by Diisopropylphosphorofluoridate^*

1965 • 45 citations

Reaction of Ficin with Diisopropylphosphorofluoridate. Evidence for a Contaminating Inhibitor^*

1965 • 44 citations

Studies on the mechanisms of invasion in cancer. III. Purification of a neutral protease of rat ascites hepatoma cell associated with production of chemotactic factor for cancer cells

1974 • 39 citations

Cytotoxicity of isolated plasma membranes from lymph node cells

1975 • 36 citations

Cell surface-associated lysosomal enzymes in cultured human skin fibroblasts

1979 • 34 citations

Bone marrow erythropoiesis in anemia of inflammation.

1974 • 20 citations

Demonstration of (Na++K+)-sensitive ATPase activity in rabbit polymorphonuclear leukocyte membranes

1976 • 19 citations

Cancer-induced cytolysis of normal bone marrow cells

1977 • 18 citations

Purification and Characterization of a Human Neutrophil Neutral Protease

1979 • 16 citations

Bone marrow cytolysis induced by hepatoma, teratocarcinoma, and transformed fibroblasts.

1979 • 9 citations

Pharmacological studies of the mechanism of tumor-induced bone marrow cytolysis.

1979 • 7 citations

Pharmacological studies comparing the mechanism of tumor-induced and activated macrophage-induced bone marrow cytolysis.

1980 • 3 citations