Targeted Anticytokine Therapy in Patients With Chronic Heart Failure

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

A Trial of Etanercept, a Recombinant Tumor Necrosis Factor Receptor:Fc Fusion Protein, in Patients with Rheumatoid Arthritis Receiving Methotrexate

1999 • 2,117 citations

Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure

2003 • 1,504 citations

Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial

2000 • 1,463 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Etanercept for active Crohn's disease: A randomized, double-blind, placebo-controlled trial

2001 • 910 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

Pathophysiologically Relevant Concentrations of Tumor Necrosis Factor-α Promote Progressive Left Ventricular Dysfunction and Remodeling in Rats

1998 • 810 citations

Treatment of Ankylosing Spondylitis by Inhibition of Tumor Necrosis Factor α

2002 • 679 citations

TREATMENT OF ANKYLOSING SPONDYLITIS BY INHIBITION OF TUMOR NECROSIS FACTOR a

2002 • 482 citations

Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

1999 • 462 citations

Case Reports of Heart Failure after Therapy with a Tumor Necrosis Factor Antagonist

2003 • 450 citations

Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction

2000 • 423 citations

Safety and Efficacy of a Soluble P75 Tumor Necrosis Factor Receptor (Enbrel, Etanercept) in Patients With Advanced Heart Failure

1999 • 397 citations

Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure

2001 • 388 citations

Results of Targeted Anti–Tumor Necrosis Factor Therapy With Etanercept (ENBREL) in Patients With Advanced Heart Failure

2001 • 386 citations

Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor

2001 • 375 citations

Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failure.

1991 • 348 citations

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis.

1994 • 174 citations

Effect of a chimeric antibody to tumor necrosis factor-alpha on cytokine and physiologic responses in patients with severe sepsis-A randomized, clinical trial

1998 • 122 citations

Tumor necrosis factor in myocardial hypertrophy and ischaemia — an anti-apoptotic perspective

2000 • 82 citations