Hypoxia-inducible Factor-1α mRNA Contains an Internal Ribosome Entry Site That Allows Efficient Translation during Normoxia and Hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

1997 • 1,610 citations

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

1998 • 496 citations

Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution.

1983 • 393 citations

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

1995 • 332 citations

AUUUA Is Not Sufficient To Promote Poly(A) Shortening and Degradation of an mRNA: the Functional Sequence within AU-Rich Elements May Be UUAUUUA(U/A)(U/A)

1994 • 331 citations

C-Myc 5′ untranslated region contains an internal ribosome entry segment

1998 • 319 citations

Hypoxia Is a Strong Inducer of Vascular Endothelial Growth Factor mRNA Expression in the Heart

1993 • 308 citations

A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

1999 • 300 citations

Two Independent Internal Ribosome Entry Sites Are Involved in Translation Initiation of Vascular Endothelial Growth Factor mRNA

1998 • 290 citations

Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription

1998 • 256 citations

Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia

1998 • 221 citations

c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis

2000 • 217 citations

Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene

1995 • 199 citations

AUUUA is not sufficient to promote poly(A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A).

1994 • 189 citations

Identification of Vascular Endothelial Growth Factor (VEGF) Receptor-2 (Flk-1) Promoter/Enhancer Sequences Sufficient for Angioblast and Endothelial Cell-Specific Transcription in Transgenic Mice

1999 • 183 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

Translation of CUG- but not AUG-initiated forms of human fibroblast growth factor 2 is activated in transformed and stressed cells.

1996 • 157 citations

Regulation of Protein Synthesis

1967 • 133 citations

Cell inactivation and cell cycle inhibition as induced by extreme hypoxia: the possible role of cell cycle arrest as a protection against hypoxia‐induced lethal damage

1991 • 112 citations

Internal Initiation of Translation Directed by the 5′-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation

1996 • 105 citations

Human Actin Genes Are Single Copy for α-Skeletal and α-Cardiac Actin but Multicopy for β- and γ-Cytoskeletal Genes: 3′ Untranslated Regions Are Isotype Specific but Are Conserved in Evolution

1983 • 94 citations

The vascular endothelial growth factor mRNA contains an internal ribosome entry site

1998 • 82 citations

Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions

2000 • 74 citations

Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2

1997 • 68 citations

Translation of NRF mRNA Is Mediated by Highly Efficient Internal Ribosome Entry

2000 • 64 citations

Hypoxia increases the association of 4E‐binding protein 1 with the initiation factor 4E in isolated rat hepatocytes

1999 • 62 citations

Regulation of protein synthesis in human cells exposed to extreme hypoxia.

1995 • 60 citations