B Cell Apoptosis Triggered by Antigen Receptor Ligation Proceeds Via a Novel Caspase-Dependent Pathway

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization

1998 • 1,226 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Ca ²⁺ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

1999 • 1,136 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process

1999 • 730 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Defects in regulation of apoptosis in caspase-2-deficient mice

1998 • 688 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

The CARD domain: a new apoptotic signalling motif

1997 • 532 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

1993 • 514 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

1996 • 451 citations

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

1996 • 440 citations

Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

1994 • 419 citations

T cell antigen receptor signal transduction

1997 • 390 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

Peripheral deletion of self-reactive B cells

1991 • 353 citations

The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32

1996 • 295 citations

Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

1990 • 253 citations

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

1997 • 252 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40.

1994 • 210 citations

Activation of Caspase-2 in Apoptosis

1997 • 181 citations

Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes

1996 • 166 citations

Functional Activation of Nedd2/ICH-1 (Caspase-2) Is an Early Process in Apoptosis

1997 • 142 citations

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

1999 • 119 citations

A subset of anti‐CD21 antibodies promote the rescue of germinal center B cells from apoptosis

1993 • 109 citations

Characterization of Lymphoma-Derived Cell Lines: Comparison of Cell Lines Positive and Negative for Epstein-Barr Virus Nuclear Antigen. II. Surface Markers

1980 • 94 citations

Specific Activation of the Cysteine Protease CPP32 during the Negative Selection of T Cells in the Thymus

1997 • 92 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

Mechanisms of selection and differentiation in germinal centers

1997 • 75 citations

Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death.

1992 • 73 citations

Molecular and Cellular Mechanisms of T Lymphocyte Apoptosis

1998 • 72 citations

Ligation of CD40 rescues Ramos‐Burkitt lymphoma B cells from calcium ionophore‐ and antigen receptor‐triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP

1996 • 70 citations

A Comparison of Signaling Requirements for Apoptosis of Human B Lymphocytes Induced by the B Cell Receptor and CD95/Fas

1998 • 68 citations

Processing of the Nedd2 precursor by ICE‐like proteases and granzyme B

1996 • 61 citations

Co‐ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI‐231 cells from anti‐surface IgM‐induced apoptosis

1995 • 56 citations

Caspase activation by BCR cross‐linking in immature B cells: differential effects on growth arrest and apoptosis

1999 • 52 citations

Growth regulation of a human mature B cell line, B104, by anti-IgM and anti-IgD antibodies.

1991 • 51 citations

Dissection of Pathways Leading to Antigen Receptor-Induced and Fas/CD95-Induced Apoptosis in Human B Cells

1998 • 48 citations

Involvement of LFA-1/intracellular adhesion molecule-1-dependent cell adhesion in CD40-mediated inhibition of human B lymphoma cell death induced by surface IgM crosslinking.

1994 • 46 citations

Signals and susceptibility to programmed death in B cells

1996 • 35 citations

Cyclosporin A and FK506 block the negative signaling mediated by surface IgM cross-linking in normal human mature B cells

1993 • 16 citations