Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential

Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS)

1997 • 1,123 citations

Presbycusis

2005 • 993 citations

The Role of Oxidative Stress in Noise-Induced Hearing Loss

2006 • 831 citations

Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness

1999 • 669 citations

Connexin26 mutations associated with the most common form of non- syndromic neurosensory autosomal recessive deafness (DFNB1) in Mediterraneans

1997 • 613 citations

Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis

1995 • 590 citations

Barttin is a Cl- channel β-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion

2001 • 545 citations

Mutation of BSND causes Bartter syndrome with sensorineural deafness and kidney failure

2001 • 506 citations

K+ cycling and the endocochlear potential

2002 • 433 citations

Targeted Ablation of Connexin26 in the Inner Ear Epithelial Gap Junction Network Causes Hearing Impairment and Cell Death

2002 • 428 citations

Targeted disruption of mouse Pds provides insight about the inner-ear defects encountered in Pendred syndrome

2001 • 407 citations

Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter

1999 • 396 citations

Inner Ear Defects Induced by Null Mutationof the isk Gene

1996 • 395 citations

Mechano‐electrical transduction currents in isolated vestibular hair cells of the chick.

1985 • 395 citations

Mice Lacking the Basolateral Na-K-2Cl Cotransporter Have Impaired Epithelial Chloride Secretion and Are Profoundly Deaf

1999 • 386 citations

Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential

2003 • 347 citations

Molecular Genetics of Hearing Loss

2001 • 322 citations

KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential

2002 • 319 citations

Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss

2002 • 305 citations

The fine structure of spiral ligament cells relates to ion return to the stria and varies with place-frequency

1996 • 298 citations

Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice

2000 • 297 citations

Mechanisms of endocochlear potential generation by stria vascularis

1987 • 295 citations

Prevalence and Evolutionary Origins of the del(GJB6-D13S1830) Mutation in the DFNB1 Locus in Hearing-Impaired Subjects: a Multicenter Study

2003 • 289 citations

Expression of the gap-junction connexins 26 and 30 in the rat cochlea

1998 • 276 citations

Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice

1998 • 274 citations

Ototoxicity: therapeutic opportunities

2005 • 268 citations

Salt Wasting and Deafness Resulting from Mutations in Two Chloride Channels

2004 • 264 citations

Gap junction systems in the mammalian cochlea

2000 • 254 citations

Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model

2004 • 251 citations

Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange– Nielsen Syndrome

2001 • 244 citations

Ion transport mechanisms responsible for K+ secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro

1995 • 240 citations

Differentiation of inner ear fibrocytes according to their ion transport related activity

1991 • 230 citations

Distribution of immunoreactive Na+,K+-ATPase in gerbil cochlea.

1989 • 228 citations

Ion Transport in Guinea Pig Cochlea:I. Potassium and Sodium Transport

1978 • 216 citations

Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice

2003 • 197 citations

Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear

2005 • 196 citations

The fine structure of freeze-fractured intercellular junctions in the guinea pig inner ear

1975 • 193 citations

Immunohistochemical Localization of the Na-K-Cl Co-transporter (NKCC1) in the Gerbil Inner Ear

1997 • 177 citations

Expression of the P2X₂Receptor Subunit of the ATP-Gated Ion Channel in the Cochlea: Implications for Sound Transduction and Auditory Neurotransmission

1999 • 163 citations

Mutation of the Na-K-Cl Co-Transporter Gene Slc12a2 Results in Deafness in Mice

1999 • 163 citations

Calcium permeation of the turtle hair cell mechanotransducer channel and its relation to the composition of endolymph

1998 • 160 citations

Mechanism Generating Endocochlear Potential: Role Played by Intermediate Cells in Stria Vascularis

2000 • 159 citations

Enlarged vestibular aqueduct: a radiological marker of Pendred syndrome, and mutation of the PDS gene

2000 • 146 citations

Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions

2005 • 145 citations

The B1-subunit of the H⁺ATPase is required for maximal urinary acidification

2005 • 139 citations

Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca²⁺ signaling than homomeric counterparts

2005 • 136 citations

Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness

2001 • 135 citations

Fine structure of the intracochlear potential field. I. The silent current

1990 • 129 citations

DC Potentials and Energy Balance of the Cochlear Partition

1951 • 126 citations

Two mechanisms for transducer adaptation in vertebrate hair cells

2000 • 123 citations

Immunological identification of an inward rectifier K + channel (Kir4.1) in the intermediate cell (melanocyte) of the cochlear stria vascularis of gerbils and rats

1999 • 120 citations

Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3

2003 • 118 citations

Stimulus‐related potassium changes in the organ of Corti of guinea‐pig.

1989 • 116 citations

Localization of pH regulating proteins H+ATPase and exchanger in the guinea pig inner ear

1997 • 113 citations

Vesicular Storage of Adenosine Triphosphate in the Guinea-pig Cochlear Lateral Wall and Concentrations of ATP in the Endolymph during Sound Exposure and Hypoxia

2001 • 113 citations

Pathology of the Ear in the Cardio-Auditory Syndrome of Jervell and Lange-Nielsen (Recessive Deafness with Electrocardiographic Abnormalities)

1966 • 111 citations

Slowly activating voltage-dependent K+ conductance is apical pathway for K+ secretion in vestibular dark cells

1994 • 90 citations

Regulation of Endolymphatic Fluid Volume

2001 • 85 citations

P2X₂Receptor Mediates Stimulation of Parasensory Cation Absorption by Cochlear Outer Sulcus Cells and Vestibular Transitional Cells

2001 • 85 citations

The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors

1987 • 81 citations

Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications

2005 • 77 citations

Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance

2004 • 73 citations

Connexin29 Is Highly Expressed in Cochlear Schwann Cells, and It Is Required for the Normal Development and Function of the Auditory Nerve of Mice

2006 • 73 citations

Effects of barium and ion substitutions in artificial blood on endocochlear potential

1985 • 71 citations

Distribution of immunoreactive alpha- and beta-subunit isoforms of Na,K-ATPase in the gerbil inner ear.

1994 • 71 citations

Electrochemical heterogeneity of the cochlear endolymph: effect of acetazolamide

1984 • 68 citations

Expression of an inwardly rectifying K⁺ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in the establishment of endocochlear potential

2004 • 67 citations

Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal

2005 • 67 citations

Purinergic Modulation of Cochlear Partition Resistance and Its Effect on the Endocochlear Potential in the Guinea Pig

2004 • 65 citations

Expression of connexin 26 and Na,K-ATPase in the developing mouse cochlear lateral wall: functional implications

1999 • 64 citations

Expression of the connexin43- and connexin45-encoding genes in the developing and mature mouse inner ear

2004 • 64 citations

Ionic changes in cochlear endolymph of the guinea pig induced by acoustic injury

1988 • 62 citations

Histochemical localization of carbonic anhydrase in the inner ear

1983 • 60 citations

Vitamin D deficiency—a new cause of cochlear deafness

1983 • 58 citations

Dye-coupling of melanocytes with endothelial cells and pericytes in the cochlea of gerbils

1998 • 58 citations

Mondini Cochlea in Pendred's Syndrome A Histological Study

1986 • 58 citations

Sidedness of action of loop diuretics and ouabain on nonsensory cells of utricle: A micro-Ussing chamber for inner ear tissues

1987 • 57 citations

Immunolocalization of ClC-K chloride channel in strial marginal cells and vestibular dark cells

2001 • 56 citations

K+ and Na+ absorption by outer sulcus epithelial cells

1999 • 55 citations

Potentials of outer hair cells and their membrane properties in cationic environments

1980 • 53 citations

Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: a possible contribution to the endocochlear potential

1998 • 53 citations

Ultrastructural localization of the Na-K-Cl cotransporter in the lateral wall of the rabbit cochlear duct

1997 • 53 citations

Respiratory rate and atp content of stria vascularis of guinea pig in vitro

1978 • 53 citations

Potassium secretion by nonsensory region of gerbil utricle in vitro

1987 • 52 citations

Effects of noise on cochlear potentials and endolymph potassium concentration recorded with potassium-selective electrodes

1979 • 49 citations

K+-induced swelling of vestibular dark cells is dependent on Na+ and Cl? and inhibited by piretanide

1990 • 48 citations

Expression of ATP-gated ion channels by Reissnerʼs membrane epithelial cells

1998 • 48 citations

Mice lacking the B1 subunit of H+-ATPase have normal hearing

2003 • 47 citations

Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome

2002 • 46 citations

Changes in Ca++ activity and DC potential in experimentally induced endolymphatic hydrops

1986 • 45 citations

Neuro-otological findings in Pendred syndrome: Hallazgos neuro-otológicos en el Sindrome de Pendred

2003 • 44 citations

A new spontaneous mouse mutation in the Kcne1 gene

2000 • 42 citations

cAMP increases K+ secretion via activation of apical IsK/KvLQT1 channels in strial marginal cells

1997 • 40 citations

Expression of connexin 30 in the developing mouse cochlea

2001 • 40 citations

K+-induced stimulation of K+ secretion involves activation of the IsK channel in vestibular dark cells

1996 • 40 citations

K+ Secretion in Strial Marginal Cells is Stimulated via β1-Adrenergic Receptors but not via β2-Adrenergic or Vasopressin Receptors

2000 • 39 citations

Glutamine synthetase and glutamate metabolism in the guinea pig cochlea

1996 • 38 citations

Reduction of the Endocochlear Potential by the New “Loop” Diuretic, Bumetanide

1978 • 37 citations

Early effects of acetazolamide on anionic activities of the guinea pig endolymph: Evidence for active function of carbonic anhydrase in the cochlea

1987 • 36 citations

Reduction of the Endocochlear Potential by the New “Loop” Diuretic, Bumetanide

1978 • 35 citations

I(sK) Channel in Strial Marginal Cells. Voltage-Dependence, Ion-Selectivity, Inhibition by 293B and Sensitivity to Clofilium.

1997 • 35 citations

mRNA encoding ‘ClC-K1, a kidney Cl−- channel’ is expressed in marginal cells of the stria vascularis of rat cochlea: its possible contribution to Cl− currents

2000 • 34 citations

Localization of β1-Adrenergic Receptors in the Cochlea and the Vestibular Labyrinth

2004 • 31 citations

Calcium transport mechanism in the endolymph of the chinchilla

1988 • 30 citations

Sensorineural hearing loss associated with hypoparathyroidism

1987 • 28 citations

The fast activating potassium current, IK,f, in guinea-pig inner hair cells is regulated by protein kinase A

1999 • 27 citations

Plasmalemmal ATPase calcium pump localizes to inner and outer hair bundles

1997 • 25 citations

Expression and Functional Phenotype of MouseERGK⁺Channels in the Inner Ear: Potential Role in K⁺Regulation in the Inner Ear

2005 • 25 citations

Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epithelium

2005 • 24 citations

Accumulation of Potassium in Scala Vestibuli Perilymph of the Mammalian Cochlea

1993 • 23 citations

Round window pH manipulation alters the ototoxicity of systemic cisplatin

2003 • 22 citations

clc is co-expressed with clf or cntfr in developing mouse muscles.

2005 • 20 citations

Enzyme-histochemical localization of carbonic anhydrase in the inner ear of the guinea pig and several improvements of the technique

1996 • 20 citations

Gap Junctions Mediate Glucose Transport Between GLUT1-Positive and -Negative Cells in the Spiral Limbus of the Rat Cochlea

2006 • 20 citations

Maxi-K+ channel in plasma membrane of basal cells dissociated from the stria vascularis of gerbils

1996 • 20 citations

Functional β<sub>2</sub>-Adrenergic Receptors Are Present in Nonstrial Tissues of the Lateral Wall in the Gerbil Cochlea

2001 • 18 citations

K + Secretion in Strial Marginal Cells is Stimulated via β 1 -Adrenergic Receptors but not via β 2 -Adrenergic or Vasopressin Receptors

2000 • 14 citations