DNA Hypomethylation, Cancer, the Immunodeficiency, Centromeric Region Instability, Facial Anomalies Syndrome and Chromosomal Rearrangements

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

A gene hypermethylation profile of human cancer.

2001 • 2,043 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

Suppression of intestinal neoplasia by DNA hypomethylation

1995 • 712 citations

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.

1994 • 667 citations

Hypomethylation of ras oncogenes in primary human cancers

1983 • 507 citations

Reduced genomic 5-methylcytosine content in human colonic neoplasia.

1988 • 491 citations

Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.

1995 • 304 citations

Methyl groups in carcinogenesis: effects on DNA methylation and gene expression.

1992 • 301 citations

An embryonic-like methylation pattern of classical satellite DNA is observed in ICF syndrome

1993 • 281 citations

Hypomethylation of pericentromeric DNA in breast adenocarcinomas

1998 • 263 citations

Jumping Translocations of Chromosome 1q in Multiple Myeloma: Evidence for a Mechanism Involving Decondensation of Pericentromeric Heterochromatin

1998 • 222 citations

DNA hypomethylation and unusual chromosome instability in cell lines fromICF syndrome patients

2000 • 209 citations

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency

1993 • 204 citations

Tissue-specific differences in DNA methylation in various mammals

1983 • 204 citations

5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

1979 • 182 citations

Frequent Hypomethylation in Wilms Tumors of Pericentromeric DNA in Chromosomes 1 and 16

1999 • 179 citations

DNA demethylation and pericentromeric rearrangements of chromosome 1

1997 • 176 citations

Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2

2000 • 165 citations

Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential

1999 • 151 citations

Positions of Potential:Nuclear Organization and Gene Expression

2001 • 134 citations

Possible epigenetic mechanisms of tumor progression: Induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment

1984 • 125 citations

DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes

2001 • 114 citations

Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis

1997 • 83 citations

Azacytidine-induced tumorigenesis of CHEF/18 cells: correlated DNA methylation and chromosome changes.

1983 • 80 citations

α-Satellite DNA methylation in normal individuals and in ICF patients: heterogeneous methylation of constitutive heterochromatin in adult and fetal tissues

1997 • 77 citations

Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.

1986 • 69 citations

Preferential induction of chromosome 1 multibranched figures and whole-arm deletions in a human pro-B cell line treated with 5-azacytidine or 5-azadeoxycytidine

1997 • 64 citations

Localization of the ICF Syndrome to Chromosome 20 by Homozygosity Mapping

1998 • 57 citations

Liver cell turnover in rats fed a choline-devoid diet

1987 • 53 citations

Oncogene-Induced Transformation of a Rat Embryo Fibroblast Cell Line is Enhanced by Tumor Promoters

1986 • 46 citations

Hypomethylation of the rat glutathione S-transferase pi (GSTP) promoter region isolated from methyl-deficient livers and GSTP-positive liver neoplasms

1998 • 39 citations

Comparison of effect of tumor promoter treatments on DNA methylation status and gene expression in B6C3F1 and C57BL/6 mouse liver and in B6C3F1 mouse liver tumors

1997 • 35 citations

Covalent modification and repressed transcription of a gene in hepatoma cells.

1981 • 30 citations

Induction of a Step in Carcinogenesis That Is Normally Associated with Mutagenesis by Nonmutagenic Concentrations of 5-Azacytidine

1984 • 29 citations

Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome

2000 • 22 citations

Production of thyroid tumours in mice by demethylating agents

1992 • 21 citations

Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine.

1984 • 17 citations

5-Azacytidine in Refractory Acute Leukemia

1982 • 8 citations