Comparative effects on the immune system of methotrexate and trimetrexate

IMMUNIZATION OF DISSOCIATED SPLEEN CELL CULTURES FROM NORMAL MICE

1967 • 2,062 citations

The cellular pharmacology of methotrexate

1985 • 254 citations

Polygammaglutamyl metabolites of methotrexate

1973 • 171 citations

Chemistry and biochemistry of folates

1984 • 100 citations

In vitro augmentation of rat natural killer (NK) cell activity.

1981 • 95 citations

Biochemical pharmacology of the lipophilic antifolate, trimetrexate

1984 • 95 citations

2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (TMQ), a potent non-classical folate antagonist inhibitor—I

1979 • 81 citations

Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells.

1978 • 78 citations

Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil

1973 • 74 citations

Effects of adriamycin on the activity of mouse natural killer cells.

1980 • 72 citations

Methotrexate cytotoxicity in cultured human leukemic cells studied by flow cytometry.

1981 • 55 citations

Immunosuppression and Serious Infections in Children with Acute Lymphoblastic Leukaemia:a Comparison of Three Chemotherapy Regimes

1980 • 41 citations

Synthesis of Methotrexate Polyglutamates by Bone Marrow Cells from Patients with Leukemia and Lymphoma

1980 • 41 citations

The influence of methotrexate and thymidine on the human natural killer cell function in vitro.

1983 • 30 citations

Modulation of methotrexate toxicity by thymidine: sequence-dependent biochemical effects.

1980 • 30 citations

Mechanisms of Action and Clinical Applications of Cytotoxic Drugs in Rheumatic Disorders

1985 • 29 citations

Some Observations on the Reversibility of Methotrexate Toxicity in Normal Proliferating Tissues2

1977 • 28 citations

Synthesis of Folate Polyglutamates in Human Cells

1976 • 27 citations

Microassay for photometric quantitation of macrophage mediated tumor cytotoxicity using an automated densitometer

1984 • 21 citations

High-Dose Methotrexate for Osteosarcoma: Toxicity and Clinical Results

1983 • 20 citations

Effects of subchronic exposure to diethylstilbestrol on humoral immune function in adult female (C3B6)F1 mice

1984 • 18 citations

Down regulation of RNA labeling as a selective marker for cytotoxic but not suppressor macrophages.

1984 • 18 citations

Augmentation of immune responses after methotrexate administration.

1979 • 17 citations

Biochemical Mechanisms of Resistance to Antimetabolites

2015 • 17 citations

Effect of Hydrocortisone, Cyclophosphamide, Azathioprine and Methotrexate on Cutaneous Delayed and Arthus Hypersensitivity in the Rat

1979 • 15 citations

Macrophage Antitumor Activity in vitro. Comparative Analysis of Cytolytic, Cytostatic, and Cytotoxic Activities of Mouse Macrophages and Human Monocytes

1984 • 14 citations

The Effect of Methotrexate on in Vitro Immutoglobulin Production

1985 • 10 citations

Serum profiles of methotrexate after its administration in children with acute lymphoblastic leukaemia

1982 • 7 citations

Selective stimulation of a cellular immune response by methotrexate

1974 • 7 citations