Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine and amino(α)carboline

Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

1995 • 553 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.

1989 • 488 citations

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

1991 • 473 citations

Food-derived mutagens and carcinogens.

1992 • 450 citations

Mutagens-carcinogens in foods.

1983 • 372 citations

Carcinogenicities of heterocyclic amines in cooked food

1991 • 318 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food

1991 • 258 citations

A clonal marker induced by mutation in mouse intestinal epithelium

1988 • 255 citations

Effect of cooking time and temperature on the heterocyclic amine content of fried beef patties

1994 • 222 citations

Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grill scrapings

1993 • 194 citations

Induction of Lymphoma in CDF₁ Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1989 • 186 citations

Exposure to heterocyclic amines.

1993 • 175 citations

Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulin

1978 • 154 citations

Comparison of somatic mutation in a transgenic versus host locus.

1993 • 145 citations

Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity

1987 • 127 citations

Development of a short-term,in vivomutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice

1990 • 121 citations

Carcinogenicity in mice and rats of heterocyclic amines in cooked foods.

1986 • 102 citations

A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes

1985 • 97 citations

Amino-α-carbolines as mutagenic agents in cigarette smoke condensate

1980 • 96 citations

Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU‐treated big blue™ B6C3F1 mice

1995 • 91 citations

Formation of a glutathione conjugate and a semistable transportable glucuronide conjugate of N²-oxidized species of 2-amino-1-methyl-6phenylimidazo[4,5-b]pyridine (PHIP) in rat liver

1991 • 84 citations

System Issues: Mutagenic response of the endogenoushprt gene andlacl transgene in benzo[a]pyrene-treated Big Blue™ B6C3F1 mice

1996 • 77 citations

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

1989 • 71 citations

Organization of heterologous DNA inserts on the mouse meiotic chromosome core

1994 • 71 citations

Factors affecting somatic mutation frequencies in vivo

1995 • 50 citations

Treatment protocols for transgenic mutation assays in vivo

1995 • 49 citations

The accumulation and persistence of somatic mutations in vivo

1994 • 41 citations

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is a potent mutagen in the mouse small intestine.

1994 • 38 citations

Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea.

1995 • 38 citations

Site-specific induction of nuclear anomalies (apoptotic bodies and micronuclei) by carcinogens in mice.

1984 • 35 citations

Cytogenetic analysis of mice chronically fed the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine

1996 • 32 citations

Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells

1990 • 27 citations

The lacI transgenic mouse mutagenicity assay: quantitative evaluation in comparison to tests for carcinogenicity and cytogenetic damage in vivo

1994 • 25 citations

Risk estimation from somatic mutation assays

1996 • 22 citations

Detection of chemically induced somatic mutation in Chinese hamsters

1977 • 20 citations

Exposure to Heterocyclic Amines

1993 • 18 citations

Nucleic acids induce the formation of a carcinogen, 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) in a model system

1993 • 17 citations

THE GRANULOMA POUCH ASSAY

1983 • 14 citations

The food-mutagens 2-ammo-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MelQx) initiate enzyme-altered hepatic foci in the resistant hepatocyte model

1989 • 8 citations

Organization of heterologous DNA inserts on the mouse meiotic chromosome core

1994 • 5 citations