The lacI transgenic mouse mutagenicity assay: quantitative evaluation in comparison to tests for carcinogenicity and cytogenetic damage in vivo

Registry of Toxic Effects of Chemical Substances

1986 • 1,127 citations

The induction of micronuclei as a measure of genotoxicity

1983 • 761 citations

Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.

1991 • 473 citations

Mammalian in vivo and in vitro cytogenetic assays

1981 • 287 citations

Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector

1991 • 197 citations

The Carcinogenic Potency Database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program.

1991 • 95 citations

Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia.

1982 • 88 citations

The use of transgenic mice for short-term, in vivo mutagenicity testing

1990 • 85 citations

The ED01 study: introduction, objectives, and experimental design.

1980 • 51 citations

Induction of micronuclei in mouse and hamster bone-marrow by chemical carcinogens

1977 • 47 citations

Medizinische Statistik

1951 • 46 citations

Can nongenotoxic carcinogens be detected with the lacl transgenic mouse mutation assay?

1993 • 45 citations

Mutations in liver DNA of lacI transgenic mice (Big Blue) following subchronic exposure to 2-acetylaminofluorene

1993 • 45 citations

The accumulation and persistence of somatic mutations in vivo

1994 • 41 citations

Mutagenic effects of combinations of chemical carcinogens and environmental pollutants in mice as shown by the micronucleus test

1982 • 40 citations

Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction

1975 • 38 citations

Persistence of preclastogenic damage in hepatocytes of rats exposed to ethylnitrosourea, diethylnitrosamine, dimethylnitrosamine and methyl methanesulphonate. Correlation with DNA O-alkylation

1986 • 32 citations

Genetic and related effects: An updating of selected IARC monographs from Volumes 1 to 42.

1987 • 29 citations

The effect of ethylnitrosourea on chromosome aberrations in vitro and in vivo

1975 • 16 citations

<italic>Brief Communication:</italic> Cytologic Changes Induced in Rat Liver Cells by ShortTerm Exposure to Chemical Substances<xref ref-type="fn" rid="FN1">2</xref>

1975 • 10 citations

Chromosomal changes associated with urethan leukemogenesis in mice

1969 • 8 citations