Changes in the specificity of antibodies by site-specific mutagenesis followed by random mutagenesis

A fast algorithm for particle simulations

1987 • 4,825 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system

1988 • 1,947 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

Human Antibodies with Sub-nanomolar Affinities Isolated from a Large Non-immunized Phage Display Library

1996 • 1,021 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops

1992 • 616 citations

Accurate modeling of protein conformation by automatic segment matching

1992 • 558 citations

Selection of phage antibodies by binding affinity

1992 • 514 citations

Atomic level simulations on a million particles: The cell multipole method for Coulomb and London nonbond interactions

1992 • 419 citations

Implementing the fast multipole method in three dimensions

1991 • 228 citations

A directory of human germ‐line V_χ segments reveals a strong bias in their usage

1994 • 220 citations

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

1997 • 209 citations

Analysis of macromolecular interactions using immobilized ligands

1992 • 181 citations

Selection and Application of Human Single Chain Fv Antibody Fragments from a Semi-synthetic Phage Antibody Display Library with Designed CDR3 Regions

1995 • 174 citations

Molecular basis of crossreactivity and the limits of antibody–antigen complementarity

1993 • 162 citations

Three-dimensional Structure of an Anti-steroid Fab′ and Progesterone-Fab′ Complex

1993 • 148 citations

Expression vectors for the introduction of highly diverged sequences into the six complementarity-determining regions of an antibody

1997 • 26 citations

Changes in the specificity of antibodies against steroid antigens by introduction of mutations into complementarity-determining regions of the V(H) domain

1998 • 23 citations

Molecular characterization of monoclonal anti-steroid antibodies: Primary structures of the variable regions of seven antibodies specific for 17α-hydroxyprogesterone or 11-deoxycortisol and their pH-reactivity profiles

1991 • 12 citations

An enzyme immunoassay system with a monoclonal antibody for the determination of 11-deoxycortisol.

1987 • 5 citations