Vitamins C and E and Beta Carotene Supplementation and Cancer Risk: A Randomized Controlled Trial

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial

1999 • 3,818 citations

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

1996 • 3,608 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

2005 • 2,499 citations

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

1996 • 2,429 citations

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention

2007 • 2,208 citations

Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

1999 • 2,021 citations

A Randomized Trial of Low-Dose Aspirin in the Primary Prevention of Cardiovascular Disease in Women

2005 • 1,949 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population

1993 • 1,783 citations

The Role of Oxidative Stress in Carcinogenesis

2004 • 1,516 citations

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial

2002 • 1,394 citations

Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer

2005 • 1,160 citations

Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer

2005 • 1,106 citations

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20536 high-risk individuals: a randomised placebo-controlled trial

2002 • 1,028 citations

The SU.VI.MAX Study

2004 • 929 citations

A review of the interaction among dietary antioxidants and reactive oxygen species

2007 • 879 citations

Subtypes of Breast Cancer Show Preferential Site of Relapse

2008 • 775 citations

Low-Dose Aspirin in the Primary Prevention of Cancer

2005 • 764 citations

Modulation of Oxidant Stress In Vivo in Chronic Cigarette Smokers

1996 • 621 citations

Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis

2004 • 607 citations

A review of the epidemiological evidence for the ‘antioxidant hypothesis’

2004 • 553 citations

β-Carotene Supplementation and Incidence of Cancer and Cardiovascular Disease: the Women's Health Study

1999 • 474 citations

A Randomized Factorial Trial of Vitamins C and E and Beta Carotene in the Secondary Prevention of Cardiovascular Events in Women

2007 • 470 citations

Interaction among vitamin C, vitamin E, and beta-carotene

1995 • 460 citations

The Benefits and Hazards of Antioxidants: Controlling Apoptosis and Other Protective Mechanisms in Cancer Patients and the Human Population

2001 • 405 citations

Meta-analysis of studies on breast cancer risk and diet

2000 • 393 citations

DNA Methylation, Cancer Susceptibility, and Nutrient Interactions

2004 • 392 citations

The Suppressive Effect of Dietary Restriction and Weight Loss in the Obese on the Generation of Reactive Oxygen Species by Leukocytes, Lipid Peroxidation, and Protein Carbonylation1

2001 • 366 citations

Fruit, Vegetable, and Antioxidant Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality in a Community-dwelling Population in Washington County, Maryland

2004 • 353 citations

ReviewPart of the Series: From Dietary Antioxidants to Regulators in Cellular Signalling and Gene ExpressionReview: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C

2005 • 352 citations

Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST)

2005 • 338 citations

Early-onset parkinsonism associated with PINK1 mutations

2005 • 335 citations

Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies1,2

2006 • 331 citations

The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure

2005 • 294 citations

Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication

1997 • 221 citations

Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants, and carotenoids

1991 • 215 citations

The Effects of Iron and Vitamin C Co-supplementation on Oxidative Damage to DNA in Healthy Volunteers

1998 • 210 citations

Vegetables, fruit, antioxidants and cancer: a review of Italian studies

2001 • 202 citations

Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities

2006 • 199 citations

Efficacy of Antioxidant Supplementation in Reducing Primary Cancer Incidence and Mortality: Systematic Review and Meta-analysis

2008 • 179 citations

Fruit and vegetable consumption and gastric cancer by location and histological type: case–control and meta-analysis

2007 • 173 citations

The Suppressive Effect of Dietary Restriction and Weight Loss in the Obese on the Generation of Reactive Oxygen Species by Leukocytes, Lipid Peroxidation, and Protein Carbonylation

2001 • 172 citations

Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland)

2000 • 170 citations

Vitamin C and cancer chemoprevention: reappraisal

2003 • 155 citations

RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria.

2003 • 148 citations

Interactions between vitamins C and E in human subjects

2000 • 142 citations

Survival in Parkinson disease

2005 • 141 citations

Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer

2006 • 127 citations

β-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor γ expression and reactive oxygen species production in MCF-7 cancer cells

2007 • 125 citations

Relation of Height and Body Mass Index to Renal Cell Carcinoma in Two Million Norwegian Men and Women

2004 • 117 citations

Beta‐carotene in multivitamins and the possible risk of lung cancer among smokers versus former smokers

2008 • 115 citations

Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: A pooled analysis of 8 prospective studies

2005 • 110 citations

Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.

2003 • 108 citations

Meta‐analysis: antioxidant supplements for primary and secondary prevention of colorectal adenoma

2006 • 105 citations

Vitamin E did not prevent cardiovascular disease and cancer in healthy women Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer. The Women's Health Study: a randomized controlled trial. JAMA 2005;294:56-65.

2006 • 103 citations

Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements

2008 • 101 citations

Impact of Selenium on Mood and Quality of Life: A Randomized, Controlled Trial

2005 • 101 citations

A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra‐tumoral genetic heterogeneity and new genetic changes on recurrence

2008 • 94 citations

Chemoprevention of Precancerous Gastric Lesions With Antioxidant Vitamin Supplementation: A Randomized Trial in a High-Risk Population

2007 • 87 citations

Low-Dose Aspirin Does Not Reduce Cancer Incidence in Women Cook NR, Lee IM, Gaziano JM, et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005;294:47-55.

2005 • 87 citations

Epidemiological evidence for beta-carotene in prevention of cancer and cardiovascular disease.

1996 • 87 citations

Meta-Analysis of Antioxidant Intake and the Risk of Esophageal and Gastric Cardia Adenocarcinoma

2007 • 78 citations

Dietary Carotenoids and Risk of Colorectal Cancer in a Pooled Analysis of 11 Cohort Studies

2006 • 66 citations

Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?

2005 • 60 citations

Lung Cancer Chemoprevention: A Randomized, Double-Blind Trial in Linxian, China

2006 • 57 citations

The Women's Antioxidant Cardiovascular Study: Design and Baseline Characteristics of Participants

2004 • 52 citations

Intake of the major carotenoids and the risk of epithelial ovarian cancer in a pooled analysis of 10 cohort studies

2006 • 49 citations

Vitamin C suppresses proliferation of the human melanoma cell SK‐MEL‐2 through the inhibition of cyclooxygenase‐2 (COX‐2) expression and the modulation of insulin‐like growth factor II (IGF‐II) production

2008 • 42 citations

Executive Summary Report

2004 • 38 citations

Free Radicals: The Pros and Cons of Antioxidants

2004 • 20 citations