Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: A major factor in activation of the host immune response to the hepatitis B virus

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

Separation of leukocytes from blood and bone marrow

1968 • 2,787 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

The hepatitis B virus

1985 • 1,219 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Seroconversion from Hepatitis B e Antigen to Antibody in Chronic Type B Hepatitis

1981 • 606 citations

Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection.

1990 • 503 citations

Immunology: The ins and outs of antigen processing and presentations

1986 • 498 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Natural history of chronic hepatitis B virus infection in taiwan: Studies of hepatitis B virus DNA in serum

1985 • 418 citations

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

1994 • 411 citations

Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes.

1982 • 395 citations

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.

1991 • 363 citations

The Nucleocapsid of Hepatitis B Virus Is Both a T-Cell-Independent and a T-Cell-Dependent Antigen

1986 • 363 citations

Clinical and Histological Events Preceding Hepatitis B e Antigen Seroconversion in Chronic Type B Hepatitis

1983 • 344 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.

1991 • 302 citations

Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion.

1992 • 294 citations

Clinical, virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B

1986 • 275 citations

Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen.

1991 • 230 citations

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis.

1993 • 224 citations

Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants.

1986 • 201 citations

Immune response to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg.

1987 • 193 citations

Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein

1993 • 176 citations

The serology of chronic hepatitis B infection revisited.

1993 • 165 citations

Hepatitis B virus antigen-specific T-cell activation in patients with acute and chronic hepatitis B

1991 • 164 citations

Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B.

1987 • 163 citations

Relationship Between Expression of Hepatitis B Virus Antigens in Isolated Hepatocytes and Autologous Lymphocyte Cytotoxicity in Patients with Chronic Hepatitis B Virus Infection

1984 • 142 citations

Cellular Immune Response to HBcAg in Mother-to-Infant Transmission of Hepatitis B Virus

1992 • 132 citations

Functional characterization of cloned intrahepatic, hepatitis B virus nucleoprotein-specific helper T cell lines.

1987 • 101 citations

Serology of acute exacerbation in chronic hepatitis B virus infection

1993 • 96 citations

Changes of serum hepatitis B virus DNA in two types of clinical events preceding spontaneous hepatitis B e antigen seroconversion in chronic type B hepatitis

1987 • 84 citations

A simple, rapid and large capacity ELISA for biologically active native and recombinant human IFN gamma.

1987 • 68 citations

Quantitation of hepatitis B virus dna (HBV DNA) in serum using the spot hybridization technique and scintillation counting

1985 • 62 citations

Hepatitis B core antigen-specific IFN-gamma production of peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection.

1989 • 60 citations

Presentation and Immunogenicity of Viral Epitopes on the Surface of Hybrid Hepatitis B Virus Core Particles Produced in Bacteria

1990 • 58 citations

Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B.

1986 • 42 citations

Controversial glycosaminoglycan conformations

1985 • 33 citations

Cytotoxic T lymphocytes recognize an HLA-A2 restricted epitope within the hepatitis B virus nucleocapsid antigen

1991 • 29 citations

[42] Peptide vaccines based on enhanced immunogenicity of peptide epitopes presented with T-cell determinants or hepatitis B core protein

1989 • 29 citations

Host immune response and variations in the virus genome: pathogenesis of liver damage caused by hepatitis B virus.

1994 • 27 citations

Increased frequency of CD8+ CD45R0+ memory T lymphocytes in acute hepatitis B virus infection

1993 • 19 citations

Effect of interferon α, γ, and tumor necrosis factor α on the HLA‐A, B, C expression of cell lines derived from human liver

1989 • 17 citations

Cellular Immune Responses of Peripheral Blood Mononuclear Cells to HBV Antigens during Chronic and Acute HBV Infection

1992 • 17 citations

Relative immunogenicity of hepatitis B virus-encoded antigens as targets for cytotoxic T-cell response.

1993 • 8 citations

Effect of Recombinant Interferon-γ on Protein Content, Phagocytic, and Cytotoxic Activity of Mouse Peritoneal Macrophages

1988 • 6 citations