Discovery of functional noncoding elements by digital analysis of chromatin structure

Basic local alignment search tool

1990 • 87,358 citations

<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool

2002 • 8,153 citations

Serial Analysis of Gene Expression

1995 • 3,659 citations

Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

2000 • 1,356 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

Controlling the double helix

2003 • 1,102 citations

Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage

2003 • 721 citations

Using the transcriptome to annotate the genome

2002 • 637 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Bioinformatics Methods and Protocols

1999 • 465 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

The insulation of genes from external enhancers and silencing chromatin

2002 • 291 citations

Chromatin Unfolds

1996 • 253 citations

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors

2002 • 222 citations

Digital karyotyping

2002 • 219 citations

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

1983 • 190 citations

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

2004 • 182 citations

Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

2004 • 181 citations

Locus control regions, chromatin activation and transcription

1998 • 142 citations

NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region.

1995 • 137 citations

Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries

2004 • 133 citations

Molecular biology: Anatomy of hypersensitive sites

1984 • 119 citations

Mechanism of DNase I hypersensitive site formation within the human globin locus control region.

1992 • 95 citations

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

1993 • 90 citations

Quantification of DNaseI-sensitivity by real-time PCR: quantitative analysis of DNaseI-hypersensitivity of the mouse β-globin LCR 1 1Edited by J. Karn

2001 • 89 citations

Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.

1988 • 88 citations

Genomic Signature Tags (GSTs): A System for Profiling Genomic DNA

2002 • 33 citations