The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. Metoabolic Effects of Menadione in Isolated Islets

A Flexible System of Enzymatic Analysis

1972 • 4,133 citations

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

Enzyme and metabolic inhibitors

1963 • 1,529 citations

The influence of calcium on sodium efflux in squid axons

1969 • 961 citations

Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme

1969 • 898 citations

The interrelationship between sodium and calcium fluxes across cell membranes

2005 • 598 citations

The stimulus-secretion coupling of glucose-induced insulin release

1979 • 420 citations

Pancreatic Beta-Cell Web: Its Possible Role in Insulin Secretion

1972 • 360 citations

The Use of C14O2 Yields from Glucose-1- and -6-C14 for the Evaluation of the Pathways of Glucose Metabolism

1963 • 352 citations

Insulin release: The fuel hypothesis

1979 • 351 citations

Interrelationship of islet metabolism, adenosine triphosphate content and insulin release

1973 • 307 citations

Metabolism of Glucose in the Islets of Langerhans

1968 • 307 citations

The pentose cycle and insulin release in mouse pancreatic islets

1972 • 304 citations

Potassium ions and the secretion of insulin by islets of Langerhans incubated in vitro

1968 • 301 citations

Electrical Activity in Pancreatic Islet Cells

1968 • 301 citations

The stoicheiometry of the sodium pump

1967 • 300 citations

Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. III. Uptake of⁴⁵Calcium by Isolated Islets of Langerhans1

1971 • 287 citations

Ultrastructural morphometry of the pancreatic ?-cell

1973 • 264 citations

Calmodulin Activation of Adenylate Cyclase in Pancreatic Islets

1979 • 234 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. VII. A PROPOSED SITE OF ACTION FOR ADENOSINE-3′,5′-CYCLIC MONOPHOSPHATE

1972 • 209 citations

D-Glucose inhibits potassium efflux from pancreatic islet cells

1978 • 208 citations

Electrical activity in pancreatic islet cells: effect of ions

1970 • 193 citations

Effects of Carbohydrates on the Oxygen Consumption of Isolated Pancreatic Islets of Mice

1967 • 169 citations

The role of sodium and potassium in insulin secretion from rabbit pancreas

1968 • 167 citations

The Stimulus-secretion Coupling of Glucose-induced Insulin Release: V. The Participation of a Microtubular-microfilamentous System

1971 • 164 citations

The stimulus-secretion coupling of glucose-induced insulin release. I. Interaction of epinephrine and alkaline earth cations.

1970 • 162 citations

Sodium-calcium exchange and calcium-calcium exchange in internally dialyzed squid giant axons

1975 • 147 citations

The pancreatic β-cell recognition of insulin secretagogues. Effects of calcium and sodium on glucose metabolism and insulin release

1974 • 140 citations

Stimulus-secretion coupling of glucose-induced insulin release. X. Effect of glucose on 45 Ca efflux from perifused islets

1973 • 139 citations

Evidence for mediated transport of glucose in mammalian pancreatic β-cells

1971 • 131 citations

A portrait of the pancreatic B-Cell

1974 • 129 citations

Calcium-antagonists and islet function

1976 • 128 citations

The stimulus secretion coupling of glucose-induced insulin release

1978 • 126 citations

REGULATION OF CALCIUM FLUXES AND THEIR REGULATORY ROLES IN PANCREATIC ISLETS*

1978 • 123 citations

Adenine Nucleotides in the Secretory Granule Fraction of Rat Islets¹

1975 • 121 citations

The functional significance of sodium channels in pancreatic beta‐cell membranes

1977 • 119 citations

The Roles of Intracellular and Extracellular Ca++ in Glucose-Stimulated Biphasic Insulin Release by Rat Islets

1978 • 119 citations

Evidence for control of serotonin secretion from human platelets by hydroxyl ion transport and osmotic lysis.

1977 • 118 citations

[Further studies on the dynamic aspects of insulin release in vitro with evidence for a two-compartmental storage system].

1969 • 116 citations

Insulin Secretion Mechanisms and Glucose Metabolism in Isolated Islets

1972 • 114 citations

Association of Glyceraldehyde 3-Phosphate Dehydrogenase with the Human Erythrocyte Membrane

1973 • 112 citations

The Pancreatic β-Cell Recognition of Insulin Secretagogues: Does Cyclic AMP Mediate the Effect of Glucose?

1974 • 112 citations

Evidence for stimulation of anion transport in ATP-evoked transmitter release from isolated secretory vesicles.

1978 • 112 citations

Regulation of calcium fluxes in pancreatic islets: dissociation between calcium and insulin release.

1978 • 108 citations

STUDIES OF THE METABOLISM OF HUMAN ERYTHROCYTE MEMBRANES*

1963 • 105 citations

Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets

1975 • 105 citations

The stimulus-secretion coupling of glucose-induced insulin release. Fasting-induced adaptation of key glycolytic enzymes in isolated islets.

1976 • 103 citations

The Kinetics of Electrical Activity of Beta Cells in Response to a "Square Wave" Stimulation with Glucose or Glibenclamide

1976 • 101 citations

Role of anions in parathyroid hormone release from dispersed bovine parathyroid cells.

1978 • 98 citations

Stimulus-secretion coupling of glucose-induced insulin release. Metabolism of alpha- and beta-D-glucose in isolated islets.

1976 • 98 citations

The pancreatic β-cell recognition of insulin secretagogues

1974 • 98 citations

Dynamics of Insulin Release and Microtubular-Microfilamentous System. I. EFFECT OF CYTOCHALASIN B

1973 • 94 citations

The effect of mannoheptulose on the phosphorylation of glucose and the secretion of insulin by islets of Langerhans

1968 • 92 citations

Pancreatic islet cells: effects of monosaccharides, glycolytic intermediates and metabolic inhibitors on membrane potential and electrical activity.

1975 • 89 citations

The microanatomy of the islets of langerhans

1976 • 87 citations

Cytochalasin B-Induced Impairment of Glucose Metabolism in Islets of Langerhans

1976 • 86 citations

Determination of subpicomole levels of NADH and FMN using bacterial luciferase and the liquid scintillation spectrometer

1971 • 85 citations

The stimulus-secretion coupling of glucose-induced insulin release. XI. Effects of Theophylline and epinephrine on 45Ca efflux from perifused islets

1973 • 83 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. XIV. Glucose Regulation of Insular Biosynthetic Activity1

1973 • 81 citations

Interrelationship between chloride fluxes in pancreatic islets and insulin release.

1978 • 81 citations

Effect of carbohydrates upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets

1973 • 80 citations

The stimulus secretion coupling of glucose-induced insulin release

1979 • 79 citations

Organ culture of fetal rat pancreas II. Insulin release induced by amino and organic acids, by hormonal peptides, by cationic alterations of the medium and by other agents

1969 • 76 citations

ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS

1969 • 76 citations

Stimulation of insulin release by calcium

1975 • 74 citations

Transport of rubidium and sodium in pancreatic islets

1974 • 74 citations

Rapid Transient Efflux of Phosphate Ions from Pancreatic Islets as an Early Action of Insulin Secretagogues

1974 • 73 citations

The stimulus-secretion coupling of glucose-induced insulin release

1978 • 72 citations

Regulation of pentose phosphate pathway dehydrogenases by NADP+/NADPH ratios

1976 • 71 citations

The stimulus-secretion coupling of glucose-induced insulin release

1976 • 70 citations

Motile Events in Pancreatic Endocrine Cells*

1979 • 70 citations

The Stimulus‐Secretion Coupling of Glucose‐Induced Insulin Release

1974 • 70 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release: IX. The Participation of the Beta Cell Web

1972 • 69 citations

Kinetics of Insulin Release from the Perfused Rat Pancreas Caused by Glucose, Glucosamine, and Galactose

1971 • 61 citations

The stimulus-secretion coupling of glucose-induced insulin release. Does glycolysis control calcium transport in the B-cell?

1976 • 58 citations

Effect of glucose on K⁺ handling by pancreatic islets

1977 • 58 citations

Effects of Iodoacetate, Mannoheptulose and 3-O-Methyl Glucose on the Secretory Function and Metabolism of Isolated Pancreatic Islets

1977 • 57 citations

The stimulus-secretion coupling of glucose-induced insulin release. XX. Fasting: A model for altered glucose recognition by the B-cell

1976 • 56 citations

Calcium antagonists and islet function: VII. Effect of calcium deprivation

1978 • 52 citations

Pyridine Nucleotides in Pancreatic Islets During Inhibition of Insulin Release by Exogenous Insulin¹²

1976 • 51 citations

Bicarbonate modulation of glucose-9nduced biphasic insulin release by rat islets

1976 • 50 citations

Calcium-antagonists and islet function. IV. effect of D600

1976 • 50 citations

Stimulus-secretion coupling of glucose-induced insulin release. XXIX. Regulation of 86Rb+ efflux from perfused islets.

1979 • 49 citations

The stimulus -secretion coupling of glucose-induced insulin release. XIX. The insulinotropic effect of glyceraldehyde

1976 • 49 citations

Metabolic regulation of the adenine nucleotide pool

1965 • 48 citations

The effect of mannoheptulose on glucose- and pyruvate-stimulated oxygen uptake in normal mouse pancreatic islets

1972 • 47 citations

Stimulation of insulin release after raising extracellular calcium

1976 • 45 citations

Endocrine Function of the Pancreas

1974 • 45 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release - II. Interaction of Alkali and Alkaline Earth Cations

1971 • 44 citations

Measurement of lactic acid in nanomolar amounts reliability of such a method as an index of glycolysis in pancreatic islets

1976 • 43 citations

Influence of anoxia on glucose metabolism in pancreatic islets: Lack of correlation between fructose-1,6-diphosphate and apparent glycolytic flux

1975 • 42 citations

The role of the pentose phosphate shunt in glucose-induced insulin release: In vitro studies with 6-aminonicotinamide, methylene blue, NAD+, NADH, NADP+, NADPH and nicotinamide on isolated pancreatic rat islets

1973 • 41 citations

Cinemicrographic studies on beta granule movement in monolayer culture of islet cells.

1975 • 40 citations

Relationship between efflux of ionic calcium and phosphorus during excitation of pancreatic islets with glucose

1976 • 39 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. XV. Participation of Cations in the Recognition of Glucose by the β-Cell1

1973 • 39 citations

Sodium uptake by microdissected pancreatic islets: Effects of ouabain and chloromercuribenzene‐p‐sulphonic acid

1974 • 38 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release. Cationic and Secretory Effects of Menadione in the Endocrine Pancreas

1978 • 38 citations

Dynamics of calcium-induced insulin release

1977 • 38 citations

The Stimulus‐Secretion Coupling of Glucose‐Induced Insulin Release

1979 • 37 citations

Principles Underlying the Exchanges of K and Na Ions Across Cell Membranes

1960 • 36 citations

Alterations in pancreatic islet phosphate content during secretory stimulation with glucose

1979 • 35 citations

Etude de la sécrétion insulinique in vitro

1968 • 35 citations

The Stimulus-Secretion Coupling of Glucose-Induced Insulin Release - VI. Analogy Between the Insulinotropic Mechanisms of Sugars and Amino Acids

1971 • 34 citations

The stimulus–secretion coupling 4-methyl-2-oxopentanoate-induced insulin release

1979 • 33 citations

Time course studies of glucose-induced changes in glucose-6-phosphate and fructose-1, 6-diphosphate content of mouse and rat pancreatic islets

1973 • 33 citations

The role of the cytoskeleton in pancreatic B-cell function.

1979 • 32 citations

The regulation of insulin secretion

1976 • 32 citations

Energy Requirements for Insulin Release from Rat Pancreasin Vitro

1970 • 31 citations

Pyridine Nucleotide Stimulation of Insulin Release from Isolated Toadfish Insulin Secretion Granules1

1972 • 29 citations

Inhibition by verapamil of ionophore-mediated calcium translocation

1977 • 29 citations

Insulin release and phosphate ion efflux from rat pancreatic islets induced by L-leucine and its nonmetabolizable analogue, 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid.

1976 • 28 citations

Anomeric specificity for the rapid transient efflux of phosphate ions from pancreatic islets during secretory stimulation with glucose

1975 • 28 citations

Cationic environment and dynamics of insulin secretion III. Effect of the absence of potassium

1974 • 27 citations

Localization of Inorganic Phosphate in the Pancreatic B Cell and Its Loss on Glucose Stimulation

1978 • 26 citations

Correlations between adenine nucleotide levels and the velocities of rate-determining steps in the glycolysis and respiration of intact ehrlich ascites carcinoma cells

1966 • 26 citations

Glucagon and insulin release by the in vitro perfused rat pancreas. Influence of the colloid composition of the perfusate

1976 • 26 citations

Effect of Various Concentrations of Glucose on Insulin Biosynthesis

1972 • 25 citations

The stimulus-secretion coupling of glucose-induced insulin release

1974 • 25 citations

Inhibition of p-chloromercuribenzoate- and glucose-induced insulin release in vitro by methylene blue, diamide, and tert-butyl hydroperoxide.

1977 • 25 citations

NaK-ATPase in rat pancreatic islets

1977 • 25 citations

Glucose Metabolism of Pancreatic Islets Isolated from Neonatal Rats

1972 • 19 citations

Calcium antagonists and islet function

1979 • 16 citations

[³²P] Orthophosphate Efflux from Pancreatic Islets: Graded Response to Glucose Stimulation

1976 • 15 citations

Effects of glucose and acetylcholine on islet tissue NADH and insulin release

1978 • 13 citations

Dissociated responsiveness to glucose of two distinct calcium movements in pancreatic islets

1978 • 12 citations

Calcium Ion Fluxes and Insulin Release in Pancreatic Islets

1977 • 11 citations

The Heat Production of Pancreatic β‐Cells Stimulated by Glucose

1975 • 11 citations

The stimulus-secretion coupling of glucose-induced insulin release: Effects of valinomycin upon pancreatic islet function

1979 • 10 citations

Effect of 2-deoxyglucose on [32P] phosphate and insulin release from perifused rat pancreatic islets

1979 • 9 citations

Metabolic aspects of alpha-ketoisocaproic-induced insulin release in rat pancreatic islets

1977 • 9 citations

The insulinotropic action of D-erythrose

1977 • 9 citations

EFFECT OF FASTING ON 32P TRANSLOCATIONS IN PRE-LABELLED PANCREATIC ISLETS

1978 • 8 citations

Effect of Glucose on²²Na⁺Efflux in Pancreatic Islets

1978 • 6 citations

Effet insulinotrope du calcium

1971 • 3 citations

The intracellular ph of mammalian pancreatic beta-cells.

1972 • 2 citations

Effect of glucose, theophylline, Ca2+ and Ba2+ upon 86Rb+ efflux from pancreatic islets

1977 • 2 citations