Chemotherapy for brain metastases of lung cancer: A review

Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials

1995 • 2,804 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials

1996 • 2,541 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery

1993 • 1,034 citations

The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age

1994 • 649 citations

CNS metastases in small cell bronchogenic carcinoma.Increasing frequency and changing pattern with lengthening survival

1979 • 478 citations

Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group.

1997 • 474 citations

New chemotherapeutic agents prolong survival and improve quality of life in non-small cell lung cancer: a review of the literature and future directions.

1998 • 410 citations

Brain metastases in adenocarcinoma of the lung: frequency, risk groups, and prognosis.

1988 • 322 citations

Intensive chemotherapy of small cell bronchogenic carcinoma.

1977 • 253 citations

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

1998 • 221 citations

Glucocorticoid treatment for brain metastases and epidural spinal cord compression: a review.

1988 • 204 citations

Human central nervous system distribution of cis-diamminedichloroplatinum and use as a radiosensitizer in malignant brain tumors.

1982 • 195 citations

Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.

1979 • 179 citations

Brain metastases in breast cancer; natural history, prognostic factors and outcome

1993 • 170 citations

Drug Resistance in Oncology

1997 • 160 citations

Stereotactic radiosurgery: a review and comparison of methods.

1994 • 140 citations

Intracranial metastases in small cell carcinoma of the lung. Correlation of clinical and autopsy findings

1982 • 133 citations

Do anticancer agents reach the tumor target in the human brain?

1992 • 133 citations

Systemic chemotherapy of brain metastases from small-cell lung cancer: a review.

1992 • 131 citations

Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer

1983 • 126 citations

Primary chemotherapy of brain metastasis in small-cell lung cancer.

1989 • 112 citations

Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma.

1983 • 109 citations

The response of cerebral metastases in small cell lung cancer to systemic chemotherapy

1990 • 104 citations

Corticosteroid-induced magnetic resonance imaging changes in patients with recurrent malignant glioma.

1994 • 104 citations

Unlocking the Blood–Brain Barrier: A Role for RMP-7 in Brain Tumor Therapy

1996 • 101 citations

Steroid‐induced CT changes in patients with recurrent malignant glioma

1988 • 100 citations

FDG-PET screening for cerebral metastases in patients with suspected malignancy

1996 • 98 citations

Brain-only metastases of small cell lung cancer; efficacy of whole brain radiotherapy. An EORTC phase II study

1998 • 95 citations

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

1993 • 88 citations

Chemotherapy with cisplatin and teniposide for cerebral metastases in non-small cell lung cancer

1998 • 82 citations

Frequency of brain metastasis in adenocarcinoma and large cell carcinoma of the lung: Correlation with survival

1983 • 78 citations

Penetration of VP-16 (etoposide) into human intracerebral and extracerebral tumors

1984 • 77 citations

Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration.

1984 • 77 citations

The effect of CNS metastases on the survival of patients with small cell cancer of the lung

1983 • 72 citations

Chemotherapy of Cerebral Metastases from Solid Tumors

1996 • 71 citations

The bradykinin analog RMP-7 increases intracellular free calcium levels in rat brain microvascular endothelial cells.

1994 • 70 citations

The Effect of Steroids on the Extravascular Distribution of Radiographic Contrast Material and Technetium Pertechnetate in Brain Tumors as Determined by Computed Tomography

1976 • 68 citations

Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.

1995 • 67 citations

A randomised clinical study of verapamil in addition to combination chemotherapy in small cell lung cancer

1993 • 66 citations

Concentrations of vinblastine in human intracerebral tumor and other tissues

1983 • 63 citations

Penetration of etoposide into human malignant brain tumors after intravenous and oral administration

1992 • 62 citations

Carboplatin as second line treatment for recurrent or progressive brain metastases from small cell lung cancer

1993 • 58 citations

TPDC-FuHu chemotherapy for the treatment of recurrent metastatic brain tumors.

1997 • 57 citations

Brain metastases from small cell lung cancer treated with combination chemotherapy

1988 • 55 citations

Response of Brain Metastases from Lung Cancer to Systemic Chemotherapy with Carboplatin and Etoposide

1996 • 52 citations

High dose etoposide for brain metastases of small cell lung cancer. A phase II study

1989 • 47 citations

A phase II trial of fotemustine and cisplatin in central nervous system metastases from non-small cell lung cancer

1996 • 44 citations

Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer a phase I/II study

1990 • 43 citations

Prospective evaluation of the effect on initial brain metastases from small cell lung cancer of platinum-etoposide based induction chemotherapy followed by an alternating multidrug regimen

1993 • 42 citations

Survival of Patients with Extensive Small-Cell Lung Cancer Who Have Only Brain Metastases at Initial Diagnosis

1997 • 41 citations

Human central nervous system and plasma pharmacology of mitoxantrone

1988 • 39 citations

Penetration of N-(phosphonacetyl)-L-aspartate into human central nervous system and intracerebral tumor.

1980 • 36 citations

Penetration of methylglyoxal bis(guanylhydrazone) into intracerebral tumors in humans.

1981 • 36 citations

Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration

1990 • 34 citations

Central nervous system as sanctuary site of relapse in patients treated with chemotherapy for metastatic testicular cancer

1994 • 32 citations

Primary chemotherapy of brain metastasis in small-cell lung cancer

1990 • 31 citations

Phase II study of nitrosourea fotemustine as single-drug chemotherapy in poor-prognosis non-small-cell lung cancer

1994 • 30 citations

High-dose methotrexate in small cell lung cancer: Lack of efficacy in preventing CNS relapse

1983 • 28 citations

Teniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lung

1988 • 26 citations

26 Mitomycin, ifosfamide and cisplatin (MIC) in non-small cell lung cancer (NSCLC): 3. Results of a randomised trial evaluating palliation & quality of life

1997 • 26 citations

Human central nervous system pharmacology of pentamethylmelamine and its metabolites

1983 • 25 citations

Treatment of brain metastases of lung cancer with high doses of etoposide (VP16–213). Cooperative study from the groupe français pneumo-cancérologie

1988 • 24 citations

248 High incidence of isolated brain metastases (CNSMets) following complete response (CR) in advanced non-small cell lung cancer (NSCLC): A new challenge

1997 • 18 citations

[Chemotherapy with high-dose cisplatin in brain metastasis of lung cancers].

1990 • 17 citations

Results of whole brain radiotherapy for brain metastases of small cell lung cancer

1993 • 17 citations

Metabolic and hemodynamic evaluation of brain metastases from small cell lung cancer with positron emission tomography.

1998 • 17 citations

Carboplatin in association with etoposide and either adriamycin or epirubicin for untreated small cell lung cancer: A dose escalation study of carboplatin

1989 • 14 citations

Brain relapses in chemotherapy-treated small cell lung cancer: a retrospective review of two time-dose regimens of therapeutic brain irradiation

1996 • 14 citations

[Neurotoxicity caused by cyclosporin A in renal transplantation in children].

1992 • 11 citations

Cisplatin-fotemustine combination in inoperable non-small cell lung cancer: Preliminary report of a French multicentre phase II trial

1994 • 8 citations

[Efficacy of the combination of mitomycin, ifosfamide and cisplatin with irradiation for the treatment of cerebral metastasis in non small cell lung carcinoma].

1995 • 6 citations

Acceptability of Patients with Brain Metastases for Clinical Trials of Chemotherapy for Metastatic Non-Small-Cell Lung Cancer

1996 • 4 citations

[Systemic chemotherapy for brain metastasis from small cell lung cancer].

1993 • 3 citations

176 Combination chemotherapy with cisplatin and teniposide (VM26) or etoposide (VP16) for brain metastasis of small cell lung cancer (SCLC): A phase II study

1997 • 2 citations

47 Teniposide plus Lomustinl in the treatment of brain metastasis in lung cancer

1997 • 2 citations

89 ICRF-187 enables dose escalation of the topoisomerase II poisons, etoposide and teniposide. An in vivo model targeting high-dose chemotherapy to CNS tumors

1997 • 1 citations