High-dose methotrexate in small cell lung cancer: Lack of efficacy in preventing CNS relapse

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Methotrexate: Distribution in Cerebrospinal Fluid after Intravenous, Ventricular and Lumbar Injections

1975 • 676 citations

MEDICAL RESEARCH COUNCIL COMPARATIVE TRIAL OF SURGERY AND RADIOTHERAPY FOR PRIMARY TREATMENT OF SMALL-CELLED OR OAT-CELLED CARCINOMA OF BRONCHUS

1973 • 528 citations

CNS metastases in small cell bronchogenic carcinoma.Increasing frequency and changing pattern with lengthening survival

1979 • 478 citations

Use of Plasma Pharmacokinetics to Predict and Prevent Methotrexate Toxicity

1977 • 390 citations

Alkylating agents in bronchogenic carcinoma

1969 • 353 citations

Frequency of residual and metastatic tumor in patients undergoing curative surgical resection for lung cancer.

1973 • 298 citations

Intensive chemotherapy of small cell bronchogenic carcinoma.

1977 • 253 citations

Small-Cell Carcinoma of the Lung: Combined Chemotherapy and Radiation

1978 • 232 citations

A randomized combined modality trial in small cell carcinoma of the lung comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation

1980 • 210 citations

Cyclic alternating combination chemotherapy for small cell bronchogenic carcinoma.

1979 • 179 citations

VP-16-213 monotherapy for remission induction of small cell lung cancer: a randomized trial using three dosage schedules.

1978 • 166 citations

Small cell carcinoma of the lung: Staging, paraneoplastic syndromes, treatment, and survival

1974 • 132 citations

Phase I study of high doses of methotrexate with citrovorum factor in patients with lung cancer

1972 • 126 citations

Lung cancer: Clinical trial of radiotherapy alone vs. Radiotherapy plus cyclophosphamide

1972 • 123 citations

Chemotherapy of Advanced Small-Cell Anaplastic Carcinoma

1978 • 110 citations

Clinical Pharmacology of Antineoplastic Drugs

1979 • 107 citations

SMALL-CELL CARCINOMA OF THE LUNG: ATTEMPT TO REMEDY CAUSES OF PAST THERAPEUTIC FAILURE

1976 • 106 citations

Small-Cell Carcinoma of the Lung: Therapeutic Management

1978 • 106 citations

Combination chemotherapy of advanced lung cancer.A randomized trial

1976 • 89 citations

Characteristics of the Vincristine-induced Augmentation of Methotrexate Uptake in Ehrlich Ascites Tumor Cells

1973 • 82 citations

“Total” Therapy for Small Cell Carcinoma of the Lung

1978 • 74 citations

Cyclophosphamide and CCNU in the treatment of inoperable small cell carcinoma and adenocarcinoma of the lung.

1976 • 72 citations

Cyclophosphamide-adriamycin combination chemotherapy of transplantable murine tumors.

1975 • 71 citations

BONE-MARROW EXAMINATION IN 100 CONSECUTIVE PATIENTS WITH BRONCHOGENIC CARCINOMA

1971 • 67 citations

Evaluation of methotrexate in the treatment of bronchogenic carcinoma

1975 • 56 citations

Intensive induction therapy for small cell carcinoma of the lung.

1979 • 53 citations

Management of small cell carcinoma of the lung.Therapy, staging, and biochemical markers

1976 • 51 citations

Combination chemotherapy for small cell carcinoma of the lung

1977 • 48 citations

Early Detection of Bone-Marrow Invasion in Oat-Cell Carcinoma of the Lung

1971 • 40 citations

The value of adriamycin in overcoming resistance to methotrexate in tissue culture

1976 • 39 citations

Combination chemotherapy--theory and practice.

1977 • 33 citations

Oat cell carcinoma of the lung.Combination treatment with radiotherapy and cyclophosphamide, adriamycin, vincristine, and methotrexate

1977 • 31 citations

Chemoimmunotherapy of small cell bronchogenic carcinoma

1978 • 30 citations

Combined modality treatment for oat cell carcinoma of the lung: a randomized trial 1,2,3.

1977 • 27 citations

Phase II studies of polychemotherapy regimens in small cell lung cancer.

1977 • 16 citations

Vincristine (NSC-67574) in the treatment of small-cell anaplastic carcinoma of the lung.

1976 • 13 citations

Recurrent Hepatitis Due to Methoxyflurane Anesthesia

1971 • 13 citations

Phase I trial of high-dose methotrexate with modified citrovorum factor rescue.

1978 • 13 citations