Human papillomaviruses and cervical neoplasia. I. Classification, virology, pathology, and epidemiology.

Epidemiologic Evidence Showing That Human Papillomavirus Infection Causes Most Cervical Intraepithelial Neoplasia

1993 • 1,236 citations

A Cohort Study of the Risk of Cervical Intraepithelial Neoplasia Grade 2 or 3 in Relation to Papillomavirus Infection

1992 • 952 citations

Human Papillomavirus Infection of the Cervix

2021 • 753 citations

Heterogeneity of the human papillomavirus group

1989 • 677 citations

Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm

1991 • 585 citations

Biosynthesis of Human Papillomavirus from a Continuous Cell Line Upon Epithelial Differentiation

1992 • 448 citations

Human papillomavirus type 16 and 18 gene expression in cervical neoplasias

1992 • 415 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

Recent Progress in Defining the Epidemiology of Human Papillomavirus Infection and Cervical Neoplasia

1992 • 341 citations

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.

1992 • 315 citations

The genetic drift of human papillomavirus type 16 is a means of reconstructing prehistoric viral spread and the movement of ancient human populations

1993 • 312 citations

Prevalence of HPV in cytomorphologically normal cervical smears, as determined by the polymerase chain reaction, is age‐dependent

1993 • 292 citations

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

1989 • 227 citations

Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: Analysis by in situ hybridization

1992 • 221 citations

Workshop on Papillomaviruses and Cancer

1979 • 202 citations

Type-specific human papillomavirus DNA in abnormal smears as a predictor of high-grade cervical intraepithelial neoplasia

1994 • 199 citations

Epidemiology of cervical cancer--overview.

1992 • 197 citations

Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped by in situ hybridization

1987 • 184 citations

The E6-E7 region of human papillomavirus type 18 is sufficient for transformation of NIH 3T3 and rat-1 cells

1987 • 180 citations

Episomal and integrated human papillomavirus in cervical neoplasia shown by non-isotopic in situ hybridisation.

1991 • 171 citations

Human papillomavirus type 16 DNA in cervical smears as predictor of high-grade cervical cancer

1992 • 167 citations

PROSPECTIVE EVALUATION OF RISK OF CERVICAL CANCER AFTER CYTOLOGICAL EVIDENCE OF HUMAN PAPILLOMAVIRUS INFECTION

1986 • 140 citations

Detection of low copy human papilloma virus DNA and mRNA in routine paraffin sections of cervix by non-isotopic in situ hybridisation.

1987 • 134 citations

Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation

1993 • 126 citations

Human Papillomaviruses Associated with Cervical Intraepithelial Neoplasia

1992 • 125 citations

Natural history and epidemiological features of genital HPV infection.

1992 • 123 citations

Risk Factors Associated with Cervical Human Papillomavirus Infections: A Case-Control Study

1993 • 108 citations

Detection of human papillomavirus in cervical scrapes by the polymerase chain reaction in relation to cytology: possible implications for cervical cancer screening.

1992 • 95 citations

Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers

1988 • 94 citations

Coexistence of episomal and integrated HPV16 DNA in squamous cell carcinoma of the cervix.

1994 • 94 citations

Use of semi-quantitative PCR for human papillomavirus DNA type 16 to identify women with high grade cervical disease in a population presenting with a mildly dyskaryotic smear report

1993 • 79 citations

The human papillomavirus E7 protein as a transforming and transactivating factor

1993 • 75 citations

Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs.

1993 • 74 citations

Human papillomavirus detection by hybrid capture and its possible clinical use.

1994 • 74 citations

Human Papillomavirus Messenger RNA Expression in Adenocarcinoma In Situ of the Uterine Cervix

1989 • 69 citations

Effects of human papillomavirus type 18-specific antisense oligonucleotides on the transformed phenotype of human carcinoma cell lines.

1993 • 65 citations

Integration of human papillomavirus 16 DNA and genomic rearrangements in immortalized human keratinocyte lines.

1990 • 65 citations

Interphase cytogenetics using biotin and digoxigenin labelled probes: III. Increased sensitivity and flexibility for detecting HPV in cervical biopsy specimens and cell lines.

1991 • 64 citations

In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions.

1990 • 58 citations

Sequence Variants of Human Papillomavirus Type 16 from Couples Suggest Sexual Transmission with Low Infectivity and Polyclonality in Genital Neoplasia

1993 • 57 citations

Prognostic Factors in Cervical Human Papillomavirus Infections

1992 • 55 citations

The predominant mRNA class in HPV16‐infected genital neoplasias does not encode the e6 or the E7 protein

1993 • 50 citations

Human papillomavirus type 6 in squamous cell carcinoma of the bladder and cervix

1993 • 49 citations

Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma.

1992 • 41 citations

Sequence Variation in the Noncoding Region of Human Papillomavirus Type 16 Detected by Single-Strand Conformation Polymorphism Analysis

1993 • 38 citations

Human papillomavirus type 18 and intraepithelial lesions of the cervix.

1994 • 32 citations

Demonstration of Low Frequency of Human Papillomavirus DNA in Cervical Adenocarcinoma and Adenocarcinoma In Situ by the Polymerase Chain Reaction and In Situ Hybridization

1991 • 25 citations

The cell biology of human papillomavirus transformed cells.

1989 • 24 citations

Detection of high risk human papillomavirus in routine cervical smears: strategy for screening.

1992 • 23 citations

Lack of immortalizing activity of a human papillomavirus type 16 variant DNA with a mutation in the E2 gene isolated from normal human cervical keratinocytes.

1992 • 21 citations

Human papillomaviruses and the pathogenesis of cervical neoplasia. A study byin situ hybridization

1989 • 19 citations

Verrucous carcinoma of the genital tract: is it a distinct entity?

1993 • 19 citations

Expression of human papillomavirus types 16 and 18 DNA sequences in cervical carcinoma cell lines

1988 • 16 citations

Absence of human papillomavirus type 16 E6 transcripts in HPV 16‐infected, cytologically normal cervical scrapings

1993 • 16 citations