SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

2006 • 24,853 citations

The Human Genome Browser at UCSC

2002 • 9,920 citations

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

2003 • 8,996 citations

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

2005 • 4,388 citations

A Third-Generation Lentivirus Vector with a Conditional Packaging System

1998 • 3,175 citations

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

2007 • 2,650 citations

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

2001 • 2,560 citations

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

2008 • 2,425 citations

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

2007 • 2,139 citations

Oncomine 3.0: Genes, Pathways, and Networks in a Collection of 18,000 Cancer Gene Expression Profiles

2007 • 1,979 citations

The UCSC Genome Browser Database

2003 • 1,872 citations

Cancerous stem cells can arise from pediatric brain tumors

2003 • 1,800 citations

Identification and expansion of the tumorigenic lung cancer stem cell population

2007 • 1,658 citations

Diversity of gene expression in adenocarcinoma of the lung

2001 • 1,299 citations

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

2004 • 1,025 citations

Dissecting self-renewal in stem cells with RNA interference

2006 • 969 citations

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

2009 • 913 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Chromosome aberrations in solid tumors

2003 • 805 citations

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

2008 • 710 citations

A module map showing conditional activity of expression modules in cancer

2004 • 693 citations

Pairing SOX off: with partners in the regulation of embryonic development

2000 • 631 citations

The Human Genome Browser at UCSC

2002 • 624 citations

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

2008 • 581 citations

SOX2 Silencing in Glioblastoma Tumor-Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity

2008 • 556 citations

The 2004 World Health Organization classification of lung tumors

2005 • 550 citations

Gene amplification in cancer

2006 • 517 citations

Oncogenic PI3K and its role in cancer

2005 • 505 citations

Hox cofactors in vertebrate development

2006 • 490 citations

The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer

2008 • 357 citations

Non-coding RNAs: New players in eukaryotic biology

2005 • 347 citations

A Meta-Analysis of Human Embryonic Stem Cells Transcriptome Integrated into a Web-Based Expression Atlas

2007 • 345 citations

Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells

2009 • 314 citations

Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: A phenotype/genotype correlation

1999 • 282 citations

Sox2 is important for two crucial processes in lung development: Branching morphogenesis and epithelial cell differentiation

2008 • 256 citations

Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells

2005 • 240 citations

Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer

2007 • 236 citations

SOX2 functions in adult neural stem cells

2005 • 232 citations

Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer

2007 • 230 citations

Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the phosphatidylinositol 3-kinase pathway.

2002 • 227 citations

SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis

2008 • 210 citations

Chromosomal imbalances in human lung cancer

2002 • 207 citations

Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy

2007 • 205 citations

Transdifferentiation of Ciliated Cells during Repair of the Respiratory Epithelium

2005 • 200 citations

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

2008 • 188 citations

Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation

1988 • 188 citations

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

2005 • 184 citations

Region-specific expression of chickenSox2 in the developing gut and lung epithelium: Regulation by epithelial-mesenchymal interactions

1998 • 155 citations

Deletion ofXPCleads to lung tumors in mice and is associated with early events in human lung carcinogenesis

2005 • 129 citations

Histopathologic Evaluation of Stepwise Progression of Pancreatic Carcinoma with Immunohistochemical Analysis of Gastric Epithelial Transcription Factor SOX2

2006 • 126 citations

Normal lung development and function afterSox9 inactivation in the respiratory epithelium

2005 • 102 citations

Squamous Cell Carcinoma Related Oncogene/DCUN1D1 Is Highly Conserved and Activated by Amplification in Squamous Cell Carcinomas

2006 • 98 citations

Genomic Profiles in Stage I Primary Non Small Cell Lung Cancer Using Comparative Genomic Hybridization Analysis of cDNA Microarrays

2004 • 91 citations

SCCRO (DCUN1D1) Is an Essential Component of the E3 Complex for Neddylation

2008 • 88 citations

Lung carcinomas with a basaloid pattern: a study of 90 cases focusing on their poor prognosis

2007 • 85 citations

Patterns of genomic imbalances in human solid tumors (Review).

2000 • 80 citations

Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer.

2002 • 74 citations

Telomere Shortening and Telomerase Reverse Transcriptase Expression in Preinvasive Bronchial Lesions

2005 • 73 citations

Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer

2008 • 63 citations

Genomic aberrations in squamous cell lung carcinoma related to lymph node or distant metastasis

2009 • 63 citations

Chromosomal Signatures of a Subset of High-Grade Premalignant Cervical Lesions Closely Resemble Invasive Carcinomas

2009 • 59 citations

Activation of the hedgehog pathway in a subset of lung cancers

2006 • 58 citations

Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers

2005 • 37 citations

SCCRO (DCUN1D1) Induces Extracellular Matrix Invasion by Activating Matrix Metalloproteinase 2

2008 • 36 citations

Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma

2006 • 22 citations

Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components

2006 • 12 citations

Overlapping 3q28 amplifications in the COMA cell line and undifferentiated primary sarcoma

2006 • 5 citations

Altered regulation of c-jun and its involvement in anchorage-independent growth of human lung cancers

2006 • 1 citations