Copper Chelation Delays the Onset of Prion Disease

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

The metallobiology of Alzheimer's disease

2003 • 1,256 citations

Copper Stimulates Endocytosis of the Prion Protein

1998 • 586 citations

Copper binding to the prion protein: Structural implications of four identical cooperative binding sites

1999 • 541 citations

Normal prion protein has an activity like that of superoxide dismutase

1999 • 520 citations

Location and properties of metal-binding sites on the human prion protein

2001 • 471 citations

Copper and immunity

1998 • 344 citations

Copper Binding to the N-Terminal Tandem Repeat Region of Mammalian and Avian Prion Protein: Structural Studies Using Synthetic Peptides

1995 • 313 citations

Strain-specific prion-protein conformation determined by metal ions

1999 • 292 citations

Raman Spectroscopic Study on the Copper(II) Binding Mode of Prion Octapeptide and Its pH Dependence

1999 • 252 citations

Prion Protein Binds Copper within the Physiological Concentration Range

2001 • 249 citations

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry

2000 • 238 citations

Brain Copper Content and Cuproenzyme Activity Do Not Vary with Prion Protein Expression Level

2000 • 196 citations

Aberrant metal binding by prion protein in human prion disease

2001 • 192 citations

Immunization Delays the Onset of Prion Disease in Mice

2002 • 190 citations

Purification and properties of the cellular prion protein from Syrian hamster brain

1992 • 187 citations

The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 179 citations

Metal imbalance and compromised antioxidant function are early changes in prion disease

2002 • 178 citations

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

2001 • 162 citations

Copper(II)-induced Conformational Changes and Protease Resistance in Recombinant and Cellular PrP

2000 • 151 citations

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

2001 • 151 citations

Oxidative impairment in scrapie‐infected mice is associated with brain metals perturbations and altered antioxidant activities

2001 • 148 citations

Reversibility of Scrapie Inactivation Is Enhanced by Copper

1998 • 131 citations

Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus 1 1Edited by F. Cohen

2000 • 115 citations

Anti-prion antibodies for prophylaxis following prion exposure in mice

2003 • 112 citations

Metal imbalance and compromised antioxidant function are early changes in prion disease

2002 • 108 citations

Prion protein expression aids cellular uptake and veratridine-induced release of copper

1999 • 103 citations

Preclinical Changes in Weight of Scrapie-lnfected Mice as a Function of Scrapie Agent-Mouse Strain Combination

1984 • 76 citations

Histopathological Similarities between Scrapie and Cuprizone Toxicity in Mice

1971 • 69 citations

Prion Infection Impairs Copper Binding of Cultured Cells

2003 • 63 citations

Prions and the lymphoreticular system

2001 • 57 citations

Immunodiagnosis of Prion Disease

1997 • 51 citations

Copper Binding to the PrP Isoforms: a Putative Marker of Their Conformation and Function

2001 • 39 citations

Copper and prion diseases

2002 • 32 citations

A comparison of the biochemical changes induced in mouse brain by cuprizone toxicity and by scrapie infection

1974 • 31 citations

Diagnosis and treatment of Wilson’s disease

2002 • 28 citations

Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform

2003 • 14 citations

d-Penicillamine toxicity in mice I. Pathological findings

1980 • 8 citations

d-Penicillamine toxicity in mice. II. Concentrations of Cu, Zn, and Fe related to development of toxicity

1982 • 6 citations