Prion Protein Binds Copper within the Physiological Concentration Range

Calculation of protein extinction coefficients from amino acid sequence data

1989 • 5,198 citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Fluorescence quenching studies with proteins

1981 • 1,700 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Studying noncovalent protein complexes by electrospray ionization mass spectrometry

1997 • 1,128 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

NMR characterization of the full‐length recombinant murine prion protein, mPrP(23–231)

1997 • 720 citations

Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible

1997 • 666 citations

PyBOP®: A new peptide coupling reagent devoid of toxic by-product

1990 • 599 citations

Copper Stimulates Endocytosis of the Prion Protein

1998 • 586 citations

Copper binding to the prion protein: Structural implications of four identical cooperative binding sites

1999 • 541 citations

Prion Protein Selectively Binds Copper(II) Ions

1998 • 515 citations

Truncated Forms of the Human Prion Protein in Normal Brain and in Prion Diseases

1995 • 497 citations

Copper Protein Structures

1991 • 477 citations

Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

1992 • 468 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

Copper Binding to the N-Terminal Tandem Repeat Regions of Mammalian and Avian Prion Protein

1995 • 353 citations

Evidence of Presynaptic Location and Function of the Prion Protein

1999 • 350 citations

Influence of Amino Acid Substitutions Related to Inherited Human Prion Diseases on the Thermodynamic Stability of the Cellular Prion Protein

1999 • 317 citations

Copper Binding to the N-Terminal Tandem Repeat Region of Mammalian and Avian Prion Protein: Structural Studies Using Synthetic Peptides

1995 • 313 citations

Strain-specific prion-protein conformation determined by metal ions

1999 • 292 citations

Cellular Copper Transport

1995 • 281 citations

Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C

1990 • 263 citations

Correction for light absorption in fluorescence studies of protein-ligand interactions

1983 • 246 citations

Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry

2000 • 238 citations

Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene

1996 • 230 citations

Biochemical Fluorescence Concepts

1976 • 230 citations

Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.

1996 • 227 citations

Electrospray mass spectrometry for protein characterization

1995 • 218 citations

The Design of Metal-Binding Sites in Proteins

1993 • 155 citations

Protein design: novel metal-binding sites

1995 • 149 citations

Reversibility of Scrapie Inactivation Is Enhanced by Copper

1998 • 131 citations

Brain tissue accumulates 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process.

1988 • 123 citations

Rapid Acquisition of β-Sheet Structure in the Prion Protein Prior to Multimer Formation

1998 • 96 citations

Autonomous and Reversible Folding of a Soluble Amino-terminally Truncated Segment of the Mouse Prion Protein

1996 • 78 citations

Biocoordination chemistry: Coordination equilibria in biologically active systems

1991 • 57 citations

Spontaneous Deamidation and Isomerization of Asn108 in Prion Peptide 106–126 and in Full-Length Prion Protein

1999 • 49 citations

[11] The design and synthesis of detergents for membrane biochemistry

1986 • 33 citations

Fluorescence studies on dopamine β-monooxygenase: effects of salts, pH changes, metal-chelating agents and Cu2+

1987 • 5 citations