Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells

Oncogenes and signal transduction

1991 • 2,816 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

1996 • 1,973 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

1996 • 1,678 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1

2000 • 720 citations

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571

2002 • 675 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

1997 • 646 citations

The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways

1998 • 627 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

Src Tyrosine Kinase Is a Novel Direct Effector of G Proteins

2000 • 422 citations

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1995 • 419 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 417 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival

2000 • 365 citations

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

1994 • 317 citations

Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism

2002 • 276 citations

Molecular Cloning Of Human Paxillin, a Focal Adhesion Protein Phosphorylated by P210BCR/ABL

1995 • 275 citations

Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C

2000 • 266 citations

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1998 • 265 citations

Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade

1999 • 259 citations

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.

1991 • 224 citations

Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation

2000 • 204 citations

Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells.

1996 • 185 citations

G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

1995 • 185 citations

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

2002 • 176 citations

Lyn Associates with the Juxtamembrane Region of c-Kit and Is Activated by Stem Cell Factor in Hematopoietic Cell Lines and Normal Progenitor Cells

1997 • 165 citations

Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.

1998 • 162 citations

Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

1993 • 159 citations

Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.

1989 • 152 citations

Phosphoinositide 3‐kinase: a key biochemical signal for cell migration in response to chemokines

2000 • 147 citations

Stromal Cell-Derived Factor-1α and Stem Cell Factor/kit Ligand Share Signaling Pathways in Hemopoietic Progenitors: A Potential Mechanism for Cooperative Induction of Chemotaxis

1998 • 137 citations

Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway.

1994 • 136 citations

Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK)

2000 • 136 citations

Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes.

1996 • 130 citations

Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells.

1993 • 125 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

Src-family Tyrosine Kinases in Activation of ERK-1 and p85/p110-phosphatidylinositol 3-Kinase by G/CCKBReceptors

1999 • 108 citations

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

2001 • 107 citations

Nitric Oxide Inhibits Thrombin Receptor-activating Peptide-induced Phosphoinositide 3-Kinase Activity in Human Platelets

1999 • 98 citations

SHP2 and cbl participate in α-chemokine receptor CXCR4–mediated signaling pathways

2001 • 90 citations

Implicating the bcr/abl Gene in the Pathogenesis of Philadelphia Chromosome-Positive Human Leukemia

1991 • 88 citations

The BCR/ABL Oncogene Alters the Chemotactic Response to Stromal-Derived Factor-1

1999 • 84 citations

Consequences of BCR‐ABL Expression within the Hematopoietic Stem Cell in Chronic Myeloid Leukemia

2000 • 73 citations

Phosphatidylinositol 3-Kinase Is a Negative Regulator of Cellular Differentiation

1997 • 68 citations

Modulation of CXCR4 expression and SDF-1α functional activity during differentiation of human monocytes and macrophages

1999 • 63 citations

C5a reduces formyl peptide-induced actin polymerization and phosphatidylinositol(3,4,5)trisphosphate formation, but not phosphatidylinositol (4,5) bisphosphate hydrolysis and superoxide production, in human neutrophils.

1992 • 48 citations

Interaction of the receptor tyrosine kinase p145^c‐kit with the p210^bcr/abl kinase in myeloid cells

1996 • 44 citations

Activation of Phosphatidylinositol 3-Kinase in Cells Expressing abl Oncogene Variants

1991 • 35 citations

Pleiotropic role of lyn kinase in leukotriene B4–induced eosinophil activation

2000 • 35 citations

Mapping of Sites on the Src Family Protein Tyrosine Kinases p55^blk, p59^fyn, and p56^lynWhich Interact with the Effector Molecules Phospholipase C-γ2, Microtubule-Associated Protein Kinase, GTPase-Activating Protein, and Phosphatidylinositol 3-Kinase

1993 • 28 citations

Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha

1998 • 19 citations

SDF‐1 Has Costimulatory Effects on Human T Cells

2000 • 16 citations

From Clouds to Cores at the Spring Geophysics-Fest

1997 • 2 citations