Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2

1996 • 779 citations

Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis.

1991 • 628 citations

Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures.

1990 • 574 citations

Molecular cloning of a ligand for the flt3flk-2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells

1993 • 546 citations

Fibronectin and VLA-4 in haematopoietic stem cell–microenvironment interactions

1991 • 522 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

Peripheralization of hemopoietic progenitors in primates treated with anti-VLA4 integrin.

1993 • 455 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

1992 • 351 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

Cytokine regulation of proliferation and cell adhesion are correlated events in human CD34+ hemopoietic progenitors

1996 • 184 citations

The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

1993 • 179 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 178 citations

Stem cell factor modulates avidity of alpha 4 beta 1 and alpha 5 beta 1 integrins expressed on hematopoietic cell lines

1995 • 173 citations

Endothelial-specific gene expression directed by the tie gene promoter in vivo

1995 • 158 citations

Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells

1994 • 146 citations

Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development

1996 • 145 citations

The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis.

1994 • 139 citations

STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.

1996 • 133 citations

Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

1992 • 132 citations

Role of bone marrow matrix in normal and abnormal hematopoiesis

1994 • 126 citations

Expression and Function of Murine Receptor Tyrosine Kinases, TIE and TEK, in Hematopoietic Stem Cells

1997 • 109 citations

Roles for integrin very late activation antigen-4 in stroma-dependent erythropoiesis

1994 • 108 citations

Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.

1993 • 107 citations

The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family

1989 • 86 citations

Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells

1996 • 68 citations

Inhibition of collagen deposition in the extracellular matrix prevents the establishment of a stroma supportive of hematopoiesis in long-term murine bone marrow cultures.

1985 • 63 citations

Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1: role of activation of very late antigen (VLA)-4 and VLA-5.

1997 • 46 citations

Modulation of the adhesion of hemopoietic progenitor cells to the rgd site of fibronectin by interleukin 3

1995 • 21 citations

Isolation of tyrosine kinase related genes expressed in the early hematopoietic system

1994 • 14 citations