Chemical carcinogenesis: a current biological perspective

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

The Sequential Analysis of Cancer Development

1980 • 613 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

1983 • 446 citations

Initiation of chemical carcinogenesis requires cell proliferation

1978 • 345 citations

Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion

1980 • 336 citations

The sequential analysis of liver cancer induction

1980 • 328 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.

1980 • 243 citations

Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver.

1983 • 194 citations

Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures.

1981 • 188 citations

The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.

1976 • 188 citations

Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.

1976 • 129 citations

Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.

1981 • 103 citations

Papillomas induced by initiation–promotion differ from those induced by carcinogen alone

1983 • 90 citations

Characterization of drug-metabolizing systems in hyperplastic nodules from the livers of rats receiving 2-acetylaminofluorene in their diet

1983 • 79 citations

Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines.

1983 • 71 citations

Properties of the increased glutathione S-transferase a form in rat preneoplastic hepatic lesions induced by chemical carcinogens

1983 • 60 citations

Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

1982 • 58 citations

Histochemical demonstration of enhanced glutathione content in enzyme-altered islands induced by carcinogens in rat liver.

1980 • 58 citations

The Cell Cycle and Chemical Carcinogenesis

1983 • 47 citations

Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis

1983 • 43 citations

Isolation and characterization of endoplasmic reticulum and Golgi apparatus from hepatocyte nodules in male wistar rats.

1983 • 43 citations

An experimental method for rapid growth of liver in spleen. The survival and proliferation of chemically induced preneoplastic hepatocytes in spleen.

1983 • 27 citations

The Biology of Carcinogen-Induced Hepatocyte Nodules and Related Liver Lesions in the Rats

1982 • 21 citations

Hypolipidemics Carcinogenicity and Extrapolation of Experimental Results for Human Safety Assessments

1982 • 18 citations

Early changes in regenerating hamster pancreas following a single dose of N-nitrosobis (2-oxopropyl)amine (NBOP) administered at the peak of DNA synthesis

1981 • 14 citations

The Polypeptides of the Cytosol of Hepatocyte Nodules may Exhibit a Unique Electrophoretic Pattern

1983 • 2 citations