The sequential analysis of liver cancer induction

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

New principle for the analysis of chemical carcinogenesis

1976 • 788 citations

The Sequential Analysis of Cancer Development

1980 • 613 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine

1978 • 415 citations

Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.

1971 • 412 citations

Report of a workshop on classification of specific hepatocellular lesions in rats.

1975 • 371 citations

Induction of Liver Growth by Xenobiotic Compounds and Other Stimuli

1974 • 352 citations

Initiation of chemical carcinogenesis requires cell proliferation

1978 • 345 citations

Ethionine Carcinogenesis

1963 • 296 citations

Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1975 • 257 citations

Carcinogens: Identification and mechanisms of action

1980 • 251 citations

Australia Antigen and the Biology of Hepatitis B

1977 • 251 citations

γ-Glutamyl Transpeptidase in Transplantable, Chemically Induced Rat Hepatomas and “Spontaneous” Mouse Hepatomas<xref ref-type="fn" rid="FN2">2</xref>

1972 • 238 citations

Pathologic aspects of cirrhosis. A review.

1977 • 234 citations

Regression and persistence of hyperplastic hepatic nodules induced by N-2-Fluorenylacetamide and their relationship to hepatocarcinogenesis.

1971 • 221 citations

Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis.

1980 • 203 citations

Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

1967 • 202 citations

Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis.

1978 • 195 citations

Effects of varying the exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1973 • 193 citations

The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens.

1976 • 188 citations

Histochemistry of Gamma-Glutamyl Transpeptidase in Rat Liver During Aflatoxin B1-Induced Carcinogenesis2

1975 • 181 citations

Intrinsic Mutagenesis: A Genetic Approach to Ageing.

1975 • 177 citations

Experimentelle Erzeugung des Lebercarcinoms durch Fütterung mit o-Amidoazotoluol

1935 • 165 citations

Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.

1978 • 157 citations

Carcinogenesis--cellular evolution as a unifying thread: Presidential address.

1973 • 155 citations

Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat

1975 • 151 citations

Glutathione and Gamma Glutamyl Transpeptidase in Rat Liver During Chemical Carcinogenesis23

1976 • 149 citations

Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat

1977 • 138 citations

Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.

1976 • 129 citations

Quantitative Study on Foci of Altered Liver Cells Induced in the Rat by a Single Dose of Diethylnitrosamine and Partial Hepatectomy<xref ref-type="fn" rid="FN1">2</xref>

1972 • 125 citations

Enhancement of Spontaneous Hepatic Tumorigenesis in C3H Mice by Dietary Phenobarbital2

1973 • 122 citations

A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver.

1976 • 118 citations

Growth kinetics of diethylnitrosamine-induced, enzyme-deficient "preneoplastic" liver cell populations in vivo and in vitro.

1972 • 111 citations

Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: Their contribution to hepatocarcinogenesis in the rat

1975 • 99 citations

Enzymhistochemische und autoradiographische Untersuchungen w�hrend der Cancerisierung der Rattenleber mit Di�thylnitrosamin

1968 • 98 citations

Sex hormones and hepatic neoplasia.

1976 • 95 citations

Notizen: Histochemische Untersuchungen über die Glucose-6-Phosphatase in der Rattenleber während der Kanzerisierung durch Nitrosamine

1964 • 92 citations

Distribution of alpha-fetoprotein- and albumin-containing cells in the livers of Fischer rats fed four cycles of N-2-fluorenylacetamide.

1978 • 89 citations

Absence of Stainable Iron From Preneoplastic and Neoplastic Lesions in Rat Liver With 8-Hydroxyquinoline-Induced Siderosis

1972 • 84 citations

Probable clonal genesis of cellular islands induced in rat liver by diethylnitrosamine

1971 • 81 citations

Nature of Early Appearing, Carcinogen-Induced Liver Lesions Resistant to Iron Accumulation 2 3

1976 • 80 citations

Functional and structural alterations of liver ergastoplasmic membranes during DL-ethionine hepatocarcinogenesis.

1975 • 79 citations

Radiation Carcinogenesis: The Sequence of Events

1965 • 74 citations

Tissue Regeneration and Tumour Development

1959 • 73 citations

Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver.

1979 • 72 citations

Development of resistance to cytotoxicity during aflatoxin carcinogenesis

1977 • 68 citations

A morphological and histochemical study of carcinogenesis of the liver in rats fed 3'-methyl-4-dimethylaminoazobenzene.

1973 • 68 citations

The use of the D-T diaphorase for the detection of foci of early neoplastic transformation in rat liver

1978 • 63 citations

Hyperbasophilic foci as sites of neoplastic transformation in hepatic parenchyma.

1971 • 59 citations

Studies on plasma membranes. IX. A survey of enzyme activities displayed by plasma membranes isolated from normal and preneoplastic livers and primary and transplanted hepatomas of the rat

1969 • 59 citations

A Clonal Selection Theory of Chemical Carcinogenesis<xref ref-type="fn" rid="FN2">2</xref>

1964 • 56 citations

In vitro measurement of carcinogen‐resistant liver cells during hepatocarcinogenesis

1978 • 56 citations

Sensitivity of Normal and Neoplastic Cells to the Damaging Action of Carcinogenic Substances: A Review

1963 • 55 citations

Tumor-Associated Transplantation Antigens of Myelomas Induced in BALB/c Mice2

1972 • 52 citations

Hyperplastic areas, hyperplastic nodules, and hyperbasophilic areas as putative precursor lesions.

1976 • 51 citations

Newer insights into the pathogenesis of liver cancer.

1977 • 49 citations

A New Common Marker for Premalignant and Malignant Hepatocytes Induced in the Rat by Chemical Carcinogens2

1975 • 46 citations

The regulation of serine dehydratase and glucose-6-phosphatase in hyperplastic nodules of rat liver during diethylnitrosamine and N-2-fluorenylacetamide feeding.

1975 • 44 citations

Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver.

1977 • 41 citations

Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad.

1977 • 39 citations

Differential Toxicity Response of Normal and Neoplastic Cells In Vitro to 3,4-Benzopyrene and 3-Methylcholanthrene

1964 • 36 citations

Some effects of acute and chronic dosing with aflatoxin B1 on rat liver nuclei.

1976 • 35 citations

Morphologic and Biologic Correlation of Lesions Obtained in Hepatic Carcinogenesis in A × C Rats Given 0.025 Percent <italic>N</italic>-2-Fluorenyl-diacetamide<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1963 • 35 citations

The Interaction of Chemical Carcinogens and Cells in vitro1

2015 • 34 citations

Combined enzyme histochemical and radioautographic studies on areas of hyperplasia in the liver of rats fed N-2-fluorenylacetamide.

1973 • 34 citations

Kinetics of formation of O6-ethylguanine in, and its removal from liver DNA of rats receiving diethylnitrosamine

1977 • 31 citations

The effect of L-asparaginase on mitotic activity during N-2-fluorenylacetamide hepatocarcinogenesis: subpopulations of nodular cells.

1971 • 30 citations

Transfer of Viable Putative Preneoplastic Hepatocytes to the Livers of Syngeneic Host Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1978 • 27 citations

The natural history of neoplasia. Newer insights into an old problem.

1977 • 27 citations

Sex differences in cell proliferation and N-hydroxy-2-acetylaminofluorene sulfotransferase levels in rat liver during 2-acetylaminofluorene administration.

1972 • 26 citations

Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis.

1977 • 26 citations

Effects of 2-acetylaminofluorene on liver cell proliferation after partial hepatectomy of female rats.

1973 • 25 citations

Ultrastructural and cytochemical studies on hyperbasophilic foci with special reference to the demonstration of cell surface alterations in hepatocarcinogenesis.

1976 • 24 citations

The effects of prolonged feeding with aflatoxin B1 on adult rat liver.

1976 • 22 citations

Replication of hepatic DNA in rats treated with dimethylnitrosamine

1975 • 22 citations

Transplantation of hepatomas induced in the avian liver by MC29 leukosis virus.

1975 • 20 citations

Histochemical studies on nuclease activity and neoplastic transformation in rat liver during diethylnitrosamine carcinogenesis.

1973 • 20 citations

Zur Zentralvene gerichtete Wanderung von Leberzellen der Ratte nach partieller Hepatektomie und nach Verabfolgung von Diäthylnitrosamin

1970 • 19 citations

Induction of Tumors in the Liver of Hamsters by an Avian Adenovirus (CELO)2

1973 • 11 citations

Enzymhistochemische Untersuchungen über den Nucleosidphosphat- und Kohlenhydratstoffwechsel während der Cancerisierung der Rattenleber mit Diäthylnitrosamin (DÄNA) durch dosierte orale Zufuhr des Cancerogens

1968 • 10 citations

The role of mutations in liver tumor induction in mice.

1972 • 8 citations

The Role of Mutations in Liver Tumor Induction in Mice

1972 • 6 citations

The Immunohistochemical Detection of Chorionic Gonadotropin in Experimental Rat Hepatomas

1978 • 4 citations