Combination Therapy in Hypertension

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

2003 • 25,662 citations

Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure

2003 • 12,553 citations

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

1998 • 5,793 citations

2007 Guidelines for the Management of Arterial Hypertension

2007 • 5,786 citations

2013 ESH/ESC Guidelines for the management of arterial hypertension

2013 • 5,590 citations

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2002 • 5,558 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

2008 • 3,396 citations

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

2004 • 2,571 citations

Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

2008 • 1,998 citations

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document

2009 • 1,574 citations

Guidelines for management of hypertension: report of the fourth working party of the British Hypertension Society, 2004—BHS IV

2004 • 1,305 citations

A Calcium Antagonist vs a Non–Calcium Antagonist Hypertension Treatment Strategy for Patients With Coronary Artery Disease

2003 • 1,268 citations

Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials

2003 • 1,164 citations

Fixed-Dose Combinations Improve Medication Compliance: A Meta-Analysis

2007 • 1,034 citations

Should β blockers remain first choice in the treatment of primary hypertension? A meta-analysis

2005 • 992 citations

Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document

2009 • 886 citations

Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials

2009 • 869 citations

Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group

1993 • 841 citations

Treatment of Hypertension in the Prevention and Management of Ischemic Heart Disease

2007 • 768 citations

Treatment of Mild Hypertension Study

1993 • 633 citations

[Commentary to the article: ONTARGET Investigators, Yusuf S, Teo KK, Pogue J et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547-59].

2008 • 624 citations

Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial

2004 • 605 citations

Atenolol in hypertension: is it a wise choice?

2004 • 583 citations

Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial

2007 • 448 citations

Diuretic Therapy for Hypertension and the Risk of Primary Cardiac Arrest

1994 • 431 citations

Comparative Antihypertensive Effects of Hydrochlorothiazide and Chlorthalidone on Ambulatory and Office Blood Pressure

2006 • 425 citations

Optimisation of antihypertensive treatment by crossover rotation of four major classes

1999 • 336 citations

Rationale for Fixed-Dose Combinations in the Treatment of Hypertension

2002 • 299 citations

The combination of olmesartan medoxomil and amlodipine besylate in controlling high blood pressure: COACH, a randomized, double-blind, placebo-controlled, 8-week factorial efficacy and safety study

2008 • 272 citations

Two multicenter, 8-week, randomized, double-blind, placebo-controlled, parallel-group studies evaluating the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in adult patients with mild to moderate essential hypertension

2007 • 264 citations

A Comparison of the Efficacy and Safety of a β-Blocker, a Calcium Channel Blocker, and a Converting Enzyme Inhibitor in Hypertensive Blacks

1990 • 263 citations

Impact of Obesity on 24-Hour Ambulatory Blood Pressure and Hypertension

2005 • 253 citations

A Simplified Approach to the Treatment of Uncomplicated Hypertension

2009 • 239 citations

A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension.

2000 • 215 citations

Blood Pressure Control and Improved Cardiovascular Outcomes in the International Verapamil SR-Trandolapril Study

2007 • 206 citations

A Cluster Randomized Trial to Evaluate Physician/Pharmacist Collaboration to Improve Blood Pressure Control

2008 • 201 citations

How strong is the evidence for use of beta-blockers as first-line therapy for hypertension? Systematic review and meta-analysis

2006 • 176 citations

Predictors of Hyperkalemia Risk following Hypertension Control with Aldosterone Blockade

2009 • 155 citations

A Multifactorial Trial Design to Assess Combination Therapy in Hypertension

1994 • 150 citations

Renin Inhibition in Hypertension

2008 • 142 citations

Losartan and Low-Dose Hydrochlorothiazide in Patients With Essential Hypertension

1996 • 140 citations

Hypertension treatment in a medicare population: Adherence and systolic blood pressure control

2007 • 140 citations

Exceptional early blood pressure control rates: The ACCOMPLISH trial

2007 • 129 citations

Comparison of different therapeutic strategies in hypertension

2004 • 115 citations

Combined Enalapril and Felodipine Extended Release (ER) for Systemic Hypertension

1997 • 98 citations

Comparison of Amlodipine and Benazepril Monotherapy to Amlodipine Plus Benazepril In Patients with Systemic Hypertension: A Randomized, Double‐Blind, Placebo‐Controlled, Parallel‐Group Study

1995 • 95 citations

Insufficient Control of Blood Pressure and Incident Diabetes

2009 • 91 citations

Antihypertensive Effectiveness of Low-Dose Lisinopril-Hydrochlorothiazide Combination

1994 • 76 citations

Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk

2007 • 64 citations

Antihypertensive effectiveness of low-dose lisinopril-hydrochlorothiazide combination. A large multicenter study. Lisinopril-Hydrochlorothiazide Group

1994 • 57 citations

Evolving strategies for the use of combination therapy in hypertension

2002 • 51 citations

Time to Achieve Blood-Pressure Goal: Influence of Dose of Valsartan Monotherapy and Valsartan and Hydrochlorothiazide Combination Therapy

2007 • 51 citations

Effects of benazepril and hydrochlorothiazide, given alone and in low- and high-dose combinations, on blood pressure in patients with hypertension

1996 • 48 citations

Use of the Factorial Design and Quadratic Response Surface Models to Evaluate the Fosinopril and Hydrochlorothiazide Combination Therapy in Hypertension

1997 • 47 citations

Placebo-controlled comparison of the effects of nebivolol and low-dose hydrochlorothiazide as monotherapies and in combination on blood pressure and lipid profile in hypertensive patients.

1994 • 42 citations

Enalapril and Atenolol in Essential Hypertension: Attenuation of Hypotensive Effects in Combination

1988 • 42 citations

A Factorial Study of Combination Hypertension Treatment With Metoprolol Succinate Extended Release and Felodipine Extended ReleaseResults of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT)

2006 • 40 citations

Captopril and hydrochlorothiazide: rationale for their combination.

1987 • 38 citations

Resistant or Difficult‐to‐Treat Hypertension

2006 • 32 citations

Atenolol and chlorthalidone in combination for hypertension.

1979 • 32 citations

The Combination of Chlorthalidone with Nifedipine Does Not Exert an Additive Antihypertensive Effect in Essential Hypertensives

1991 • 32 citations

Blood Pressure-Lowering Efficacy of Amiloride versus Enalapril as Add-On Drugs in Patients with Uncontrolled Blood Pressure Receiving Hydrochlorothiazide

2008 • 29 citations

Rebound Hypertension Following Abrupt Cessation of Clonidine and Metoprolol

1987 • 28 citations

A dose escalation trial comparing the combination of diltiazem SR and hydrochlorothiazide with the monotherapies in patients with essential hypertension.

1992 • 25 citations

Felodipine–Metoprolol Combination Tablet: Maintained Health-Related Quality of Life in the Presence of Substantial Blood Pressure Reduction

2005 • 23 citations

Hydrochlorothiazide With or Without Amiloride for Hypertension in the Elderly

1987 • 21 citations

Hydrochlorothiazide with or without amiloride for hypertension in the elderly. A dose-titration study

1987 • 4 citations