Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure–activity relationships

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine receptor pharmacology

1994 • 959 citations

3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D₄ Receptor

1996 • 257 citations

α1-Adrenergic receptor regulation: basic science and clinical implications

2000 • 220 citations

Autonomic control of the venous system in health and disease: effects of drugs

2001 • 210 citations

Isoindolinone enantiomers having affinity for the dopamine D4 receptor

1998 • 201 citations

Neurobiology of schizophrenia

1997 • 157 citations

Design, Synthesis, and Evaluation of Chromen-2-ones as Potent and Selective Human Dopamine D4 Antagonists

1999 • 106 citations

L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.

1997 • 99 citations

(S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D₄ Antagonist

1996 • 97 citations

Rationally Based Efficacy Tuning of Selective Dopamine D4 Receptor Ligands Leading to the Complete Antagonist 2-[4-(4-Chlorophenyl)piperazin-1- ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213)

2001 • 92 citations

Selective dopamine D 4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition

1998 • 83 citations

Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 2: Asymmetric synthesis and biological evaluation

2002 • 55 citations

1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1,3-dihydroimidazol-2-one: A Selective High-Affinity Antagonist for the Human Dopamine D₄Receptor with Excellent Selectivity over Ion Channels

1999 • 51 citations

Schizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist

1997 • 48 citations

4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors

1999 • 44 citations

Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands

1999 • 41 citations

Synthesis, sar and pharmacology of CP-293,019: A potent, selective dopamine D4 receptor antagonist

1998 • 40 citations

Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives

2000 • 39 citations

A Rapid Convenient Reduction of Indoles to Indolines and of Tetrahydrocarbazoles to Hexahydrocarbazoles by Trimethylamine/Borane

1974 • 39 citations

trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: Mixed Dopamine D₂/D₄ Receptor Antagonists as Potential Antipsychotic Agents

2000 • 37 citations

1-Phenyl-3-(aminomethyl)pyrroles as Potential Antipsychotic Agents. Synthesis and Dopamine Receptor Binding

1995 • 35 citations

Dipole stabilized a-amino carbanions. III. Metalation-alkylation of indolines, tetrahydroquinolines and n-methylanilines.

1981 • 34 citations

A Series of 6- and 7-Piperazinyl- and -Piperidinylmethylbenzoxazinones with Dopamine D4 Antagonist Activity: Discovery of a Potential Atypical Antipsychotic Agent

1999 • 26 citations

2,2-dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands

1999 • 26 citations

A Structure−Affinity Relationship Study on Derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a High-Affinity and Selective D₄ Receptor Ligand

1999 • 25 citations

2,2-Disubstituted-1,2-dihydro-3H-indol-3-ones by base- and thermal-induced cyclisations of o-azidophenyl s-alkyl ketones and o-azidobenzoyl esters

1986 • 23 citations

6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D4 receptors

2001 • 18 citations

SAR of novel biarylmethylamine dopamine D4 receptor ligands

1998 • 17 citations

N-Benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties

1984 • 16 citations

The discovery of potent and selective dopamine D4 receptor antagonists

1998 • 14 citations

Lithium-N-lithioalkyldithiocarbamate: NeueN-Alkylaminoalkylanion-Äquivalente IV¹; Eine neue Methode zur Darstellung 2-substituierter Indoline

1994 • 11 citations