ideR , an Essential Gene in Mycobacterium tuberculosis : Role of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress Response

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

1998 • 7,572 citations

Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro

1988 • 1,505 citations

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

2000 • 1,300 citations

Iron and metal regulation in bacteria

2001 • 734 citations

Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature‐tagged transposon mutagenesis

1999 • 613 citations

The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages

2000 • 516 citations

[25] Genetic systems for mycobacteria

1991 • 437 citations

Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin

1998 • 413 citations

The Mycobacterium tuberculosis ECF sigma factor σ^E: role in global gene expression and survival in macrophages^†

2001 • 411 citations

Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

1989 • 332 citations

Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis

2000 • 319 citations

Activation of the Pro-drug Ethionamide Is Regulated in Mycobacteria

2000 • 285 citations

Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine.

1993 • 269 citations

Iron Acquisition and Metabolism by Mycobacteria

1999 • 266 citations

The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages

2001 • 254 citations

An Essential Two-Component Signal Transduction System in Mycobacterium tuberculosis

2000 • 209 citations

Exochelins of Mycobacterium tuberculosis remove iron from human iron-binding proteins and donate iron to mycobactins in the M. tuberculosis cell wall.

1996 • 201 citations

Association of Pulmonary Tuberculosis with Increased Dietary Iron

2001 • 180 citations

Biosynthesis of diaminopimelate, the precursor of lysine and a component of peptidoglycan, is an essential function of Mycobacterium smegmatis

1996 • 165 citations

YbtP and YbtQ: two ABC transporters required for iron uptake in Yersinia pestis

1999 • 162 citations

Expression of the Bacillus subtilis sacB gene confers sucrose sensitivity on mycobacteria

1996 • 155 citations

Characterization of an iron-dependent regulatory protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae

1995 • 152 citations

Identification of Fur, Aconitase, and Other Proteins Expressed by Mycobacterium tuberculosis under Conditions of Low and High Concentrations of Iron by Combined Two-Dimensional Gel Electrophoresis and Mass Spectrometry

1999 • 127 citations

An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative‐stress response

1996 • 117 citations

Crystal Structure of the Iron-dependent Regulator (IdeR) from Mycobacteriumtuberculosis Shows Both Metal Binding Sites Fully Occupied

1999 • 114 citations

Transcriptional Control of the Iron-Responsive fxbA Gene by the Mycobacterial Regulator IdeR

1999 • 106 citations

Mycobacteria : molecular biology and virulence

1999 • 98 citations

sigAis an essential gene inMycobacterium smegmatis

1998 • 96 citations

Identification and cloning of a fur homolog from Neisseria gonorrhoeae

1993 • 95 citations

The occurrence of carboxymycobactin, the siderophore of pathogenic mycobacteria, as a second extracellular siderophore in Mycobacterium smegmatis

1996 • 91 citations

Characterization of the Vibrio anguillarum fur gene: role in regulation of expression of the FatA outer membrane protein and catechols

1994 • 89 citations

Iron regulation of siderophore biosynthesis and transport in Pseudomonas putida WCS358: involvement of a transcriptional activator and of the Fur protein

1995 • 78 citations

glnE Is an Essential Gene in Mycobacterium tuberculosis

2000 • 75 citations

Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum

1995 • 60 citations

Identification and characterization of two divergently transcribed iron regulated genes in Mycobacterium tuberculosis

1999 • 59 citations

Cloning and sequence analysis of the Corynebacterium diphtheriae dtxR homologue from Streptomyces lividans and S. pilosus encoding a putative iron repressor protein

1995 • 57 citations

[1] Whole genome DNA microarray expression analysis of biofilm development by Vibrio cholerae O1 El Tor

2001 • 48 citations

Identification of iron-regulated proteins ofMycobacterium tuberculosisand cloning of tandem genes encoding a low iron-induced protein and a metal transporting ATPase with similarities to two-component metal transport systems

1998 • 36 citations

A simple method for the production of mycobactin, the lipid-soluble siderophore, from mycobacteria

1982 • 35 citations

Mechanism of Tuberculostasis in Mammalian Serum. I. Role of Transferrin in Human Serum Tuberculostasis

1969 • 34 citations

Protective role of the Mycobacterium smegmatis IdeR against reactive oxygen species and isoniazid toxicity

1998 • 32 citations

Respiratory complex I: structure, redox components, and possible mechanisms of energy transduction.

2001 • 30 citations