Expression Profiling of Single Mammalian Cells – Small is Beautiful

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Serial Analysis of Gene Expression

1995 • 3,659 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Expression profiling using cDNA microarrays

1999 • 1,689 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Amplified RNA synthesized from limited quantities of heterogeneous cDNA.

1990 • 1,258 citations

Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping

1988 • 1,107 citations

A novel family of genes encoding putative pheromone receptors in mammals

1995 • 1,003 citations

Analysis of gene expression in single live neurons.

1992 • 944 citations

Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

2000 • 868 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Gene expression profiles of laser-captured adjacent neuronal subtypes

1999 • 708 citations

High-fidelity mRNA amplification for gene profiling

2000 • 693 citations

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.

1994 • 529 citations

Amplification and characterization of a β-globin gene synthesized in vitro

1976 • 495 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

In vivo gene expression profile analysis of human breast cancer progression.

1999 • 396 citations

Immuno-LCM: Laser Capture Microdissection of Immunostained Frozen Sections for mRNA Analysis

1999 • 389 citations

Novel method for studying mRNA phenotypes in single or small numbers of cells

1989 • 382 citations

Bipotential precursors of B cells and macrophages in murine fetal liver

1992 • 367 citations

Stem cells: the intestinal stem cell as a paradigm

2000 • 314 citations

PCR-based cDNA library construction: general cDNA libraries at the level of a few cells

1989 • 285 citations

Why Stem Cells?

2000 • 282 citations

[361 Construction of cDNA libraries from single cells

1993 • 271 citations

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

1999 • 216 citations

Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology

1996 • 186 citations

Representative in Vitro cDNA Amplification From Individual Hemopoietic Cells and Colonies

1990 • 185 citations

Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells

1996 • 180 citations

Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells

1995 • 175 citations

Distinct Methylation of the Interferon γ (IFN-γ) and Interleukin 3 (IL-3) Genes in Newly Activated Primary CD8+ T Lymphocytes: Regional IFN-γ Promoter Demethylation and mRNA Expression Are Heritable in CD44highCD8+ T Cells

1998 • 171 citations

[1] Preparation of cDNA from single cells and subcellular regions

1999 • 168 citations

Single-cell analysis of Hodgkin and Reed-Sternberg cells: molecular heterogeneity of gene expression and p53 mutations

1993 • 159 citations

Laser Capture Microdissection of Single Cells from Complex Tissues

1999 • 128 citations

Quantitative Single-Cell-Reverse Transcription-PCR Demonstrates That A-Current Magnitude Varies as a Linear Function ofshalGene Expression in Identified Stomatogastric Neurons

1997 • 111 citations

Characterization of differentially expressed genes in purified Drosophila follicle cells: Toward a general strategy for cell type-specific developmental analysis

1999 • 110 citations

Impaired Granulocytic Differentiation In Vitro in Hematopoietic Cells Lacking Retinoic Acid Receptors α1 and γ

1998 • 106 citations

Variability in the expression of trophectodermal markers β-human chorionic gonadotrophin, human leukocyte antigen-G and pregnancy specific β-1 glycoprotein by the human blastocyst

1999 • 104 citations

Expression profiling of single cells using 3 prime end amplification (TPEA) PCR

1998 • 82 citations

Analysis of G protein α subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT‐PCR approach

1995 • 81 citations

Global cDNA Amplification Combined with Real-Time RT–PCR: Accurate Quantification of Multiple Human Potassium Channel Genes at the Single Cell Level

2000 • 74 citations

Transient Expression of a Translation Initiation Factor Is Conservatively Associated with Embryonic Gene Activation in Murine and Bovine Embryos1

1998 • 71 citations

Multiplex semi-quantitative reverse transcriptase–polymerase chain reaction of low abundance neuronal mRNAs

1999 • 71 citations

Translation of Maternal Messenger Ribonucleic Acids Encoding Transcription Factors During Genome Activation in Early Mouse Embryos1

2000 • 69 citations

Stage-Specific Induction and Regulation by Genomic Imprinting of the Mouse U2afbp-rs Gene during Preimplantation Development

1995 • 67 citations

Gene-expression analysis at the single-cell level

2000 • 65 citations

Cloning of chicken lysozyme structural gene sequences synthesized in vitro

1978 • 60 citations

Unicellular-Unilineage Erythropoietic Cultures: Molecular Analysis of Regulatory Gene Expression at Sibling Cell Level

1999 • 52 citations

cDNA Libraries from Single Human Preimplantation Embryos

1997 • 47 citations

Plant molecular biology: A laboratory manual

1997 • 40 citations

cDNA fingerprinting of osteoprogenitor cells to isolate differentiation stage-specific genes

1999 • 34 citations

Ultramicrochemical determination of nucleic acids in individual cells using the Zeiss UMSP-I microspectrophotometer. Application to isolated rat hepatocytes of different ploidy classes

1976 • 31 citations

Analysis of gene expression in subpopulations of murine hematopoietic stem and progenitor cells

2000 • 31 citations

Age-related changes in neuronal RNA content in rhesus monkeys (Macaca mulatta)

1980 • 30 citations

Molecular Embryology Methods and Protocols

1999 • 24 citations

A subtractive PCR-based cDNA library made from fetal thymic stromal cells

1998 • 22 citations

Single-Cell Characterization of Endothelin System Gene Expression in the Cerebellum In Situ

1998 • 21 citations

Identification of Sequence-Tagged Transcripts Differentially Expressed within the Human Hematopoietic Hierarchy

1998 • 18 citations

Expression of the imprinted tumour‐suppressor gene H19 is tightly regulated during normal haematopoiesis and is reduced in haematopoietic precursors of patients with the myeloproliferative disease polycythaemia vera

2000 • 18 citations

Expression of the imprinted tumour-suppressor gene H19 is tightly regulated during normal haematopoiesis and is reduced in haematopoietic precursors of patients with the myeloproliferative disease polycythaemia vera

2000 • 17 citations

Isolation of epiblast‐specific cDNA clones by differential hybridization with polymerase chain reaction‐amplified probes derived from single embryos

1992 • 15 citations

Generation of Full-Length cDNA Library from Single Human Prostate Cancer Cells

1999 • 13 citations

High yields of RNA and DNA suitable for array analysis from cell sorter purified epithelial cell and tissue populations

1999 • 13 citations

Gene expression in single Reed Sternberg cells of Hodgkin's disease: Results for PCR generated single cell cDNA libraries

1992 • 12 citations

Single-Cell RT-PCR cDNA Subtraction

2008 • 12 citations

Blood stem cell transplantation and gene therapy of cancer

1995 • 11 citations

Characterization of Murine Lymphokine-Activated Killer Cell Cultures Separated According to Cell Size

1993 • 7 citations

Chapter 8: Perspectives for the use of biological indicators for the assessment of radiation induced responses and impairments: Biologic indicators of exposure: Are markers associated with oncogenesis useful as biologic markers of effect?

1995 • 4 citations

[A new method of comparative analysis of gene expression and identification of differentially expressed mRNA].

1994 • 3 citations