Mechanisms of the Age-Associated Deterioration in Glucose Tolerance

Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.

1981 • 1,606 citations

Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function

1993 • 1,391 citations

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

2002 • 1,295 citations

Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach

1989 • 999 citations

Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

1992 • 804 citations

Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action*

1982 • 685 citations

Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance

1992 • 612 citations

Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin

1979 • 594 citations

Accurate Assessment of β-Cell Function

2002 • 496 citations

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations.

1993 • 467 citations

SAAM II: Simulation, analysis, and modeling software for tracer and pharmacokinetic studies

1998 • 439 citations

Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

1982 • 434 citations

Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males.

1996 • 431 citations

Characterization of the insulin resistance of aging.

1983 • 395 citations

Pathogenesis of Age-Related Glucose Intolerance in Man: Insulin Resistance and Decreased β-Cell Function*

1985 • 350 citations

Splanchnic insulin metabolism in obesity. Influence of body fat distribution.

1986 • 346 citations

Measurement of abdominal and visceral fat with computed tomography and dual-energy x-ray absorptiometry

1995 • 339 citations

Insulin Action and Age: European Group for the Study of Insulin Resistance (EGIR)

1996 • 327 citations

Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function

1993 • 320 citations

Oral Glucose Tolerance Test Minimal Model Indexes of β-Cell Function and Insulin Sensitivity

2001 • 311 citations

Strength training increases insulin action in healthy 50- to 65-yr-old men

1994 • 290 citations

Oxidative capacity of human muscle fiber types: effects of age and training status

1995 • 285 citations

Glucose tolerance in young and older athletes and sedentary men

1984 • 229 citations

The oral glucose minimal model: Estimation of insulin sensitivity from a meal test

2002 • 225 citations

Endurance Exercise Training Reduces Glucose-Stimulated Insulin Levels in 60- to 70-Year-Old Men and Women

1993 • 202 citations

Use of a novel triple-tracer approach to assess postprandial glucose metabolism

2003 • 175 citations

Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age.

1992 • 167 citations

Validation of a new method for determination of free fatty acid turnover

1987 • 166 citations

Estimation of β-Cell Sensitivity From Intravenous Glucose Tolerance Test C-Peptide Data: Knowledge of the Kinetics Avoids Errors in Modeling the Secretion

1995 • 129 citations

Effects of Aging on Insulin Secretion

1989 • 118 citations

Decrease in β-Cell Mass Leads to Impaired Pulsatile Insulin Secretion, Reduced Postprandial Hepatic Insulin Clearance, and Relative Hyperglucagonemia in the Minipig

2001 • 113 citations

Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization

1982 • 111 citations

Effects of Age and Body Fat Insulin Resistance in Healthy Men

1993 • 109 citations

Dynamic muscle strength alterations to detraining and retraining in elderly men

1997 • 108 citations

Insulin Secretion and Clearance: Comparison After Oral and Intravenous Glucose

1987 • 89 citations

Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals1

1997 • 85 citations

Influence of Age on Clearance of Insulin in Man

1982 • 83 citations

Influence of Aging on Hepatic and Peripheral Glucose Metabolism in Humans

1988 • 80 citations

Differential Rates of Release of Newly Synthesized and of Stored Insulin from Pancreatic Islets*

1982 • 76 citations

Insulin action and age. European Group for the Study of Insulin Resistance (EGIR)

1996 • 73 citations

The Metabolic Clearance of Insulin and the Feedback Inhibition of Insulin Secretion Are Altered with Aging

1985 • 71 citations

The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus

1993 • 66 citations

Insulin Sensitivity and Beta‐Cell Responsivity Are Not Decreased in Elderly Subjects With Normal OGTT

1988 • 64 citations

Peripheral and hepatic insulin sensitivity in healthy elderly human subjects

1991 • 60 citations

Age-Related Reduction in Glucose Elimination Is Accompanied by Reduced Glucose Effectiveness and Increased Hepatic Insulin Extraction in Man1

1998 • 56 citations

Reduced Beta‐Cell Secretion and Insulin Hepatic Extraction in Healthy Elderly Subjects

1990 • 55 citations

Human aging is associated with parallel reductions in insulin and amylin release

1998 • 54 citations

Relationship Between Glucose Tolerance and Glucose-Stimulated Insulin Response in 65-Year-Olds

1993 • 53 citations

Disruption of the Pulsatile and Entropic Modes of Insulin Release during an Unvarying Glucose Stimulus in Elderly Individuals¹

1999 • 47 citations

Does aging intensify the insulin resistance of human obesity?

1992 • 38 citations

β-cell function during insulin-modified intravenous glucose tolerance test successfully assessed by the C-peptide minimal model

1999 • 36 citations

Disruption of the Pulsatile and Entropic Modes of Insulin Release during an Unvarying Glucose Stimulus in Elderly Individuals

1999 • 33 citations

Serum insulin distributions and reproducibility of the relationship between 2-hour insulin and plasma glucose levels in Asian Indian, Creole, and Chinese Mauritians

1993 • 32 citations

Age-Related Reduction in Glucose Elimination Is Accompanied by Reduced Glucose Effectiveness and Increased Hepatic Insulin Extraction in Man

1998 • 32 citations

Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals

1997 • 31 citations

Assessment of Hepatic Sensitivity to Glucagon in NIDDM: Use as a Tool to Estimate the Contribution of the Indirect Pathway to Nocturnal Glycogen Synthesis

1997 • 27 citations

Effects of aging on insulin secretion

1989 • 26 citations

Influence of age on clearance of insulin in man

1982 • 25 citations

The metabolic clearance of insulin and the feedback inhibition of insulin secretion are altered with aging

1985 • 23 citations

Influence of aging on hepatic and peripheral glucose metabolism in humans

1988 • 22 citations

Control of secretion vesicle margination and lysis by glucose, IBMX, and glyburide

1985 • 14 citations

Assessment of hepatic sensitivity to glucagon in NIDDM: use as a tool to estimate the contribution of the indirect pathway to nocturnal glycogen synthesis

1997 • 9 citations

A Minimal Model of Insulin During Insulin Modified IVGTT: Assessment of Hepatic Insulin Extraction

1997 • 6 citations

Insulin Modelling

2001 • 4 citations

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