Increased Disorderliness of Basal Insulin Release, Attenuated Insulin Secretory Burst Mass, and Reduced Ultradian Rhythmicity of Insulin Secretion in Older Individuals1

Approximate entropy as a measure of system complexity.

1991 • 5,411 citations

Effects of gender and age on the levels and circadian rhythmicity of plasma cortisol.

1996 • 911 citations

Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection

1986 • 888 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Effects of arterial versus venous sampling on analysis of glucose kinetics in man

1976 • 720 citations

Abnormal Patterns of Insulin Secretion in Non-Insulin-Dependent Diabetes Mellitus

1988 • 565 citations

Cyclic Oscillations of Basal Plasma Glucose and Insulin Concentrations in Human Beings

1979 • 402 citations

Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.

1995 • 371 citations

Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males

1996 • 342 citations

Females secrete growth hormone with more process irregularity than males in both humans and rats

1996 • 272 citations

Quantification of hormone pulsatility via an approximate entropy algorithm

1992 • 268 citations

Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man

1981 • 265 citations

Ultradian Oscillations of Plasma Glucose, Insulin, and C Peptide in Man During Continuous Enteral Nutrition

1987 • 149 citations

Efficacy of Pulsatile Versus Continuous Insulin Administration on Hepatic Glucose Production and Glucose Utilization in Type I Diabetic Humans

1986 • 141 citations

Oscillations in Insulin Secretion During Constant Glucose Infusion in Normal Man: Relationship to Changes in Plasma Glucose*

1988 • 129 citations

Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus.

1993 • 125 citations

Effects of Aging on Insulin Secretion

1989 • 118 citations

Pulsatile Insulin Delivery has Greater Metabolic Effects than Continuous Hormone Administration in Man: Importance of Pulse Frequency

1991 • 102 citations

Superior Efficacy of PulsatileVersusContinuous Hormone Exposure on Hepatic Glucose Productionin Vitro*

1986 • 101 citations

Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM

1997 • 100 citations

Histological studies on the neuro-insular complex in the pancreas of some mammals

1959 • 98 citations

Role of intrapancreatic ganglia in regulation of periodic insular secretions

1985 • 90 citations

Influence of Aging on Hepatic and Peripheral Glucose Metabolism in Humans

1988 • 80 citations

NIDDM in the elderly

1996 • 79 citations

Effects of Glucose Ingestion Versus Infusion on Pulsatile Insulin Secretion: The Incretin Effect Is Achieved by Amplification of Insulin Secretory Burst Mass

1996 • 67 citations

24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.

1995 • 65 citations

Insulin-mediated increase in blood flow is impaired in the elderly.

1995 • 61 citations

Alterations in the ultradian oscillations of insulin secretion and plasma glucose in aging

1996 • 57 citations

Abnormalities in the ultradian oscillations of insulin secretion and glucose levels in Type 2 (non-insulin-dependent) diabetic patients

1992 • 56 citations

Postprandial oscillations of plasma glucose, insulin and C-peptide in man

1987 • 49 citations

Glucose Handling, Diabetes and Ageing

1995 • 48 citations

Endocrinology and Aging

1978 • 41 citations

Age-related alterations in pulsatile secretion of TSH: role of dopaminergic regulation

1991 • 38 citations

Effects of aging on glucose regulation during wakefulness and sleep

1995 • 37 citations

Altered pulsatile insulin secretion associated with endurance training

1995 • 33 citations

Splanchnic Insulin Dynamics and Secretion Pulsatilities in Abdominal Obesity

1994 • 30 citations

Assessing Temporal Coupling between Two or among Three or More Neuroendocrine Pulse Trains

1994 • 29 citations

Oscillations in Blood Glucose and Insulin After Oral Glucose

1972 • 28 citations

Alteration in the temporal organisation of insulin secretion in Type 2 (non-insulin-dependent) diabetic patients under continuous enteral nutrition

1991 • 25 citations

Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion.

1993 • 24 citations

Differential effects of glucose stimulation upon rapid pulses and ultradian oscillations of insulin secretion

1993 • 16 citations

Biphasic Patterns of Peripheral Insulin and Glucose Levels After Lunch in Normal Subjects

1987 • 11 citations

Ultrastructural detection of granulated cells in the autonomic ganglia of the rat pancreas

1985 • 9 citations