Palmitoylation of Ha-Ras Facilitates Membrane Binding, Activation of Downstream Effectors, and Meiotic Maturation in Xenopus Oocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

Protein Lipidation in Cell Signaling

1995 • 771 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.

1990 • 336 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Dynamic fatty acylation of p21N-ras.

1987 • 309 citations

Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle

1989 • 300 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes

1987 • 224 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Enzymatic Coupling of Cholesterol Intermediates to a Mating Pheromone Precursor and to the Ras Protein

1990 • 175 citations

Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

1995 • 172 citations

Induction of Xenopus Oocyte Meiotic Maturation by MAP Kinase

1995 • 154 citations

Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.

1990 • 150 citations

The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase

1993 • 139 citations

A study of the induction of cell division in amphibian oocytes by insulin

1981 • 130 citations

Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.

1989 • 106 citations

Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system.

1992 • 101 citations

Fatty acylation is important but not essential for Saccharomyces cerevisiae RAS function.

1987 • 98 citations

Ras membrane targeting is essential for glucose signaling but not for viability in yeast.

1995 • 98 citations

High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc

1993 • 94 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

Polylysine domain of K-ras 4B protein is crucial for malignant transformation.

1994 • 73 citations

Ha-rasVal-12,Thr-59 activates S6 kinase and p34cdc2 kinase in Xenopus oocytes: evidence for c-mosxe-dependent and -independent pathways.

1990 • 66 citations

Stimulation of mitogen-activated protein kinase by oncogenic Ras p21 in Xenopus oocytes. Requirement for Ras p21-GTPase-activating protein interaction.

1992 • 61 citations

The Farnesyl Group of H-Ras Facilitates the Activation of a Soluble Upstream Activator of Mitogen-activated Protein Kinase

1995 • 60 citations

Synergistic activation by Ras and 14-3-3 protein of a mitogen-activated protein kinase kinase kinase named Ras-dependent extracellular signal-regulated kinase kinase stimulator.

1994 • 55 citations

p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases.

1993 • 46 citations

Prenylation of mammalian Ras protein in Xenopus oocytes.

1990 • 44 citations

Purification and Characterization of REKS from Xenopus Eggs

1995 • 39 citations

Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.

1994 • 37 citations

Cell Biology Laboratory Manual

2013 • 36 citations

[2] Purification of baculovirus-expressed recombinant ras and rap proteins

1995 • 29 citations

[26] Detecting radiolabeled lipid-modified proteins in polyacrylamide gels

1995 • 27 citations

Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes

1994 • 23 citations

Progesterone but not ras requires MPF for in vivo activation of MAPK and S6 KII: MAPK is an essential conexion point of both signaling pathways

1994 • 22 citations