The role of inflammation in disk herniation-associated radiculopathy

Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation.

1990 • 2,436 citations

Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation.

1990 • 1,965 citations

Rupture of the Intervertebral Disc with Involvement of the Spinal Canal

1934 • 1,883 citations

Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization

1993 • 1,661 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Lumbar Disc Herniation

1983 • 1,148 citations

Descriptive Epidemiology of Low-back Pain and Its Related Medical Care in the United States

1987 • 845 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

A Study of Computer-Assisted Tomography

1984 • 718 citations

Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.

1982 • 665 citations

Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

1981 • 614 citations

High Levels of Inflammatory Phospholipase A2 Activity in Lumbar Disc Herniations

1990 • 580 citations

Herniated Lumbar Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin-6, and Prostaglandin E2

1996 • 559 citations

Herniated Cervical Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin-6, and Prostaglandin E2

1995 • 544 citations

The Inflammatory Effect of Nucleus Pulposus

1987 • 538 citations

Nonoperative Treatment of Herniated Lumbar Intervertebral Disc with Radiculopathy

1989 • 538 citations

Inflammatory Cytokines in the Herniated Disc of the Lumbar Spine

1996 • 516 citations

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

1988 • 510 citations

Autologous Nucleus Pulposus Induces Neurophysiologic and Histologic Changes in Porcine Cauda Equina Nerve Roots

1993 • 500 citations

A STUDY OF THE MECHANICS OF SPINAL INJURIES

1960 • 491 citations

Autologous Nucleus Pulposus Induces Neurophysiologic and Histologic Changes in Porcine Cauda Equina Nerve Roots

1993 • 491 citations

Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.

1991 • 448 citations

Prolapsed intervertebral disc. A hyperflexion injury 1981 Volvo Award in Basic Science.

1982 • 402 citations

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.

1988 • 396 citations

Prolapsed Intervertebral Disc

1982 • 387 citations

The Natural History of Lumbar Intervertebral Disc Extrusions Treated Nonoperatively

1990 • 380 citations

Extradural Corticosteroid Injection in Management of Lumbar Nerve Root Compression

1973 • 371 citations

Inflammatogenic Properties of Nucleus Pulposus

1995 • 352 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Human vascular smooth muscle cells. Target for and source of tumor necrosis factor.

1989 • 333 citations

Studies on Structural Changes in the Lumbar Annulus Fibrosus

1952 • 297 citations

Leukotriene B ₄ Produces Hyperalgesia That Is Dependent on Polymorphonuclear Leukocytes

1984 • 294 citations

The Role of Inflammation in Lumbar Pain

1995 • 273 citations

Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.

1986 • 259 citations

A Controlled Immunohistochemical Study of Inflammatory Cells in Disc Herniation Tissue

1994 • 258 citations

Immunohistologic Study of the Ruptured Intervertebral Disc of the Lumbar Spine

1996 • 258 citations

Chemical Radiculitis

1977 • 244 citations

The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat

1994 • 230 citations

Human Disc Phospholipase A2 is Inflammatory

1992 • 212 citations

Proteoglycans in Experimental Intervertebral Disc Degeneration

1981 • 210 citations

Sensitization of group IV muscle receptors to bradykinin by 5-hydroxytryptamine and prostaglandin E2

1981 • 210 citations

Intradiscal Measurements of pH in Patients with Lumbar Rhizopathies

1969 • 196 citations

Phospholipase A2 activity in sera and synovial fluids in rheumatoid arthritis and osteoarthritis. Its possible role as a proinflammatory enzyme.

1985 • 185 citations

Effects of Methylprednisolone on Nucleus Pulposus-Induced Nerve Root Injury

1994 • 176 citations

AUTO-IMMUNE RESPONSE TO NUCLEUS PULPOSUS IN THE RABBIT

1965 • 176 citations

Pathomechanism of Pain-Related Behavior Produced by Allografts of Intervertebral Disc in the Rat

1996 • 171 citations

A Study of Computer-Assisted Tomography Introduction

1984 • 157 citations

Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid

1988 • 152 citations

Herniated Intervertebral Disc-Associated Periradicular Fibrosis and Vascular Abnormalities Occur Without Inflammatory Cell Infiltration

1995 • 152 citations

Intervertebral Foramen Venous Obstruction

1989 • 150 citations

Neural Mechanisms of Lumbar Pain

1995 • 138 citations

Histologic Changes in Spinal Nerve Roots of Operated Cases of Sciatica

1951 • 133 citations

Role of cytokines in inflammatory synovitis

1990 • 132 citations

Prostaglandin E2 Content in Herniated Lumbar Disc Disease

1996 • 126 citations

Hyperalgesic properties of 15-lipoxygenase products of arachidonic acid.

1986 • 125 citations

Lumbosacral Arachnoiditis

1978 • 119 citations

Autoimmunity in Degenerative Disc Disease of the Lumbar Spine

1975 • 116 citations

Identification of human intervertebral disc stromelysin and its involvement in matrix degradation

1991 • 112 citations

Characterization of extracellular phospholipase A2 in rheumatoid synovial fluid

1985 • 110 citations

Activation of fine articular afferent units by bradykinin

1985 • 106 citations

Healing Potential of the Anulus Fibrosus

1989 • 103 citations

Role of Langerhans cells in epidermotropism of T cells

1988 • 102 citations

Intervertebral discs: nuclear morphology and bursting pressures.

1973 • 98 citations

Immunohistochemical observations on spinal tissue innervation: A review of hypothetical mechanisms of back pain

1991 • 92 citations

The Role of lnterleukin-1 on Proteoglycan Metabolism of Rabbit Annulus Fibrosus Cells Cultured In Vitro

1988 • 89 citations

CHEMICAL IRRITATION OF NERVE-ROOT IN DISC PROLAPSE

1973 • 88 citations

Isolation and characterization of a phospholipase A2 from an inflammatory exudate

1978 • 85 citations

Prostaglandin Release from Lumbar Disc and Facet Joint Tissue

1994 • 80 citations

Basic Fibroblast Growth Factor Immunoreactivity in Blood Vessels and Cells of Disc Herniations

1995 • 78 citations

Neutral Proteinases in Human Intervertebral Disc

1993 • 77 citations

STUDIES ON THE PATHOLOGY OF LOW BACK PAIN

1959 • 71 citations

Straight Leg Raising Test Versus Radiologic Size, Shape, and Position of Lumbar Disc Hernias

1992 • 66 citations

A Controlled Biochemical and Immunohistochemical Study of Human Synovial-Type (Group II) Phospholipase A2 and Inflammatory Cells in Macroscopically Normal, Degenerated, and Herniated Human Lumbar Disc Tissues

1996 • 65 citations

Degenerative Disk Disease of the Lumbar Spine

1977 • 63 citations

The biophysical and biochemical aspects of intervertebral disc herniation and degeneration.

1962 • 63 citations

Immunocytochemical Localization of Immunoglobulins in Disc Herniations

1996 • 58 citations

Retained surgical swab debris in post-laminectomy arachnoiditis and peridural fibrosis

1988 • 56 citations

The Stimulation of Lymphocytes by Nucleus Pulposus in Patients with Degenerative Disk Disease of the Lumbar Spine

1977 • 56 citations

IgG and IgM Concentration in the Prolapsed Human Intervertebral Disc and Sciatica Etiology

1994 • 52 citations

Isolated Intervertebral Disc Resorption

1986 • 51 citations

Concomitant immunocytochemical study of macrophage cells and blood vessels in disc herniation tissue

1994 • 44 citations

Collagenolytic Enzyme Systems in Human Intervertebral Disc

1982 • 42 citations

Neutral proteinases of the human intervertebral disc

1987 • 40 citations

Identification of IgG in the Canine Intervertebral Disc

1988 • 39 citations

In Vitro Inhibition of Leucocyte Migration in Patients with Intervertebral Disc Lesions

1975 • 37 citations

A Comparison of the Antigenic Properties of Nucleus Pulposus and Cartilage Protein Polysaccharide Complexes

1967 • 33 citations

Neurophysiologic Changes in Lumbar Nerve Root Inflammation in the Rat After Treatment With Cytokine Inhibitors

1996 • 30 citations

Prostaglandin E2 increases mechanically evoked potentials in the peripheral nerve

1981 • 29 citations

Abnormal Connective Tissue Degrading Enzyme Patterns in Prolapsed Intervertebral Discs

1986 • 29 citations

Influence of plasma proteins on activity of proinflammatory enzyme phospholipase A2

1986 • 28 citations

Auto-immunological Basis of Disk Degeneration

1976 • 17 citations

Experimental autoimmune spondylodiscitis in rats.

1986 • 17 citations

Painless root compression following disc extrusion

1982 • 16 citations

Effects of corticosteroids on cellular interactions in human joint tissues in culture

1981 • 16 citations

Synovial cytokines impair the function of the sciatic nerve in rats: a possible element in the pathophysiology of radicular syndromes

1989 • 16 citations

Experimental Biomechanics of Intervertebral Disc Rupture Through a Vertebral Body

1969 • 15 citations

Isolation and characterisation of a neutral proteinase from the canine intervertebral disc

1989 • 13 citations

Calcitonin Producing Tumour: Effects on Fracture Repair and Normal Bone in Rats

1983 • 13 citations

Phospholipases, eicosanoid production and inflammation

1982 • 9 citations