Identification of human intervertebral disc stromelysin and its involvement in matrix degradation

A modified uronic acid carbazole reaction

1962 • 6,191 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots

1984 • 2,189 citations

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

1985 • 506 citations

Lumbar Intradiscal Pressure: Experimental Studies on Post-Mortem Material

1960 • 496 citations

Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes

1987 • 474 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

Age-related changes in the structure of the proteoglycan subunits from human articular cartilage.

1980 • 338 citations

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.

1987 • 323 citations

Interaction of cartilage proteoglycans with hyaluronic acid

1977 • 303 citations

Aging and Degeneration in the Lumbar Intervertebral Disc

1977 • 132 citations

Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ

1989 • 117 citations

Extracellular matrix metabolism by chondrocytes III. Modulation of proteoglycan synthesis by extracellular levels of proteoglycan in cartilage cells in culture

1977 • 116 citations

Characterization of a Specific Antiserum to Rabbit Stromelysin and Demonstration of the Synthesis of Collagenase and Stromelysin by Stimulated Rabbit Articular Chondrocytes

1986 • 103 citations

Identification of a hyaluronic acid-binding protein that interferes with the preparation of high-buoyant-density proteoglycan aggregates from adult human articular cartilage

1985 • 94 citations

Age-related changes in the structure of proteoglycan link proteins present in normal human articular cartilage

1983 • 87 citations

The heterogeneity of link proteins isolated from human articular cartilage proteoglycan aggregates.

1982 • 84 citations

Proteoglycans of the human intervertebral disc. Electrophoretic heterogeneity of the aggregating proteoglycans of the nucleus pulposus

1988 • 78 citations

Proteoglycan Chemistry of the Intervertebral Disks

1977 • 73 citations

Ageing and the aggregating proteoglycans of human articular cartilage

1986 • 50 citations

Fine structure of juvenile human nucleus pulposus.

1970 • 49 citations

Human articular cartilage secretes characteristic metal dependent proteinases upon stimulation by mononuclear cell factor.

1986 • 46 citations

Collagenolytic Enzyme Systems in Human Intervertebral Disc

1982 • 42 citations

Neutral proteinases of the human intervertebral disc

1987 • 40 citations

Characterization of link protein(s) from human intervertebral-disc tissues

1988 • 40 citations

Effect of age on the abundance and fragmentation of link protein of the human intervertebral disc

1989 • 35 citations

The heterogeneity of the non-aggregating proteoglycans of the human intervertebral disc

1987 • 26 citations

Ultrastructure of prolapsed disc

1977 • 18 citations

Variation in the effects of mononuclear cell products from different individuals on metalloproteinase secretion from human articular cartilage.

1989 • 5 citations