Regulation of glucokinase in liver.

Methods in Enzymology , Vol

1966 • 26,261 citations

HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS

1969 • 4,428 citations

Relation of Oxygen and Temperature in the Preservation of Tissues by Refrigeration

1949 • 959 citations

Regulation in metabolism

1973 • 780 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE

1954 • 595 citations

Regulation of Glucose Uptake in Muscle

1961 • 595 citations

Dynamics of Insulin Secretion by the Perfused Rat Pancreas

1968 • 593 citations

Regulation of Glucose Uptake by Muscle

1962 • 484 citations

Multiple Hexokinases of Rat Tissues

1966 • 483 citations

Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels

1969 • 438 citations

INTERACTION OF INSULIN WITH THE CELL MEMBRANE: THE PRIMARY ACTION OF INSULIN

1969 • 381 citations

Physiology of Insulin In Man: The Banting Memorial Lecture 1971

1971 • 353 citations

Effects of Diet and Insulin on Glucose-Adenosine Triphosphate Phosphotransferases of Rat Liver

1963 • 317 citations

Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties.

1965 • 308 citations

Metabolism of Glucose in the Islets of Langerhans

1968 • 307 citations

Glucose Penetration Into Liver

1958 • 280 citations

Foetal “Antigens” in Cancer

1972 • 268 citations

Insulin-dependent Synthesis of Liver Glucokinase in the Rat

1963 • 257 citations

Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture.

1972 • 227 citations

TWO BLOCKS IN CARBOHYDRATE UTILIZATION IN THE LIVER OF THE DIABETIC RAT

1951 • 226 citations

Immunological Aspects Of Chemical Carcinogenesis

1973 • 225 citations

Hepatic Glucokinase in the Fed, Fasted, and Alloxan-Diabetic Rat

1960 • 224 citations

Studies on Glucose Phosphorylation in Rat Liver^*

1962 • 192 citations

Enzyme patterns in fetal, adult and neoplastic rat tissues

1976 • 180 citations

The multiple forms of mammalian hexokinase and their significance to the action of insulin

1967 • 163 citations

Glucokinase of Rabbit Liver

1965 • 158 citations

Humoral Syndromes Associated with Nonendocrine Tumors

1964 • 157 citations

Inhibition of Enzyme Activities by Free Fatty Acids

1968 • 154 citations

Some distinctive properties of pyruvate kinase purified from rat liver

1968 • 149 citations

On the presence of two soluble glucose-phosphorylating enzymes in adult liver and the development of one of these after birth

1963 • 145 citations

Purification and properties of adenosine 5′-triphosphate-<scp>d</scp>-glucose 6-phosphotransferase from rat liver

1966 • 140 citations

Glycolytic and gluconeogenic enzyme activities in parenchymal and non-parenchymal cells from mouse liver

1972 • 137 citations

Palmityl-coenzyme a inhibition of the citrate-condensing enzyme

1965 • 137 citations

Enzymatic reactions in carbohydrate metabolism.

1945 • 137 citations

STUDIES ON CARBOHYDRATE METABOLISM IN RAT LIVER SLICES

1955 • 134 citations

Retrogenetic Expression: the Reappearance of Embryonal Antigens in Cancer Cells

1970 • 134 citations

Metabolic Regulation by Multifunctional Glucose-6-phosphatase

1974 • 134 citations

Glucokinase of rabbit liver: purification and properties

1965 • 134 citations

A review of isozymes in cancer.

1971 • 128 citations

Enzymes Involved in Fructose Metabolism in Liver and the Glyceraldehyde Metabolic Crossroads

1969 • 127 citations

Action of glucocorticoid as inducer and insulin as suppressor of biosynthesis of hepatic gluconeogenic enzymes

1965 • 126 citations

The development of hepatic glucokinase in the neonatal rat

1965 • 122 citations

The role of glucokinase in the phosphorylation of glucose by rat liver

1964 • 120 citations

STUDIES ON CARBOHYDRATE METABOLISM IN RAT LIVER SLICES

1958 • 119 citations

Antagonism Between the Effects of Insulin and Glucagon on the Isolated Liver

1969 • 118 citations

Glucose utilization in mammalian liver

1965 • 110 citations

Effects of <scp>d</scp>-mannoheptulose and <scp>d</scp>-sedoheptulose on blood glucose and ketone bodies in the rat

1961 • 106 citations

Kinetic, electrophoretic, and chromatographic studies on glucose-ATP phosphotransferases in rat hepatomas.

1969 • 104 citations

Dietary regulation of glycolytic enzymes I. Adaptive changes in rat jejunum

1968 • 102 citations

Isozyme studies on adult, regenerating, precancerous and developing liver in relation to findings in hepatomas

1972 • 96 citations

The purification in high yield and characterization of rat hepatic glucokinase

1976 • 94 citations

Role of Enzymes in Homeostasis

1968 • 90 citations

Effects of carbohydrate availability on lipogenesis in sheep

1972 • 89 citations

Hexokinase isozyme patterns of experimental hepatomas of rats.

1969 • 88 citations

Premature Formation of Glucokinase in Developing Rat Liver

1970 • 87 citations

Hormonal and dietary regulation of hepatic glucokinase

1964 • 87 citations

Ketohexokinase, isoenzymes of glucokinase and glycogen synthesis from hexoses in neonatal rat liver

1964 • 86 citations

Fine structural and growth characteristics of cultured rat liver cells

1972 • 85 citations

Mechanism of Action of Insulin

1974 • 81 citations

Dietary and Hormonal Effects on Gluconeogenesis in the Rat

1965 • 80 citations

The control by insulin of amino acid accumulation in muscle

1970 • 79 citations

An Age-dependent Modification of Enzyme Regulation

1970 • 76 citations

Hexokinase, differentiation and growth rates of transplanted rat tumors.

1970 • 69 citations

Isoenzyme patterns in parenchymal and non-parenchymal cells isolated from regenerating and regenerated rat liver

1973 • 68 citations

Insulin-dependent synthesis of glucokinase

1965 • 66 citations

Liver glucokinase of the biotin deficient rat

1968 • 65 citations

Characterization of Isoenzymes of Adenosine Triphosphate: D-Hexose 6-Phosphotransferase from Rat Liver^*

1967 • 64 citations

Substrate attachment in enzymes. The interaction of pyridoxal phosphate with amino acids

1962 • 64 citations

Dynamic Synthesis and Release of Insulin and Proinsulin from Perifused Islets

1973 • 62 citations

Hormonal control of hexokinase activity in animal tissues

1970 • 61 citations

Cytochemical and ultrastructural alterations associated with confluent growth in cell cultures of epithelial-like cells from rat liver.

1973 • 60 citations

Effects of Glucose Feeding, Cortisol, and Insulin on Liver Glycogen Synthesis in the Rat

1967 • 59 citations

Glycolytic isoenzymes and glycogen metabolism in regenerating liver from rats on controlled feeding schedules

1973 • 59 citations

Some Consequences of the “Non-competitive” Inhibition by Glucose of Rat Liver Glucose 6-Phosphatase¹

1959 • 58 citations

Hexokinase Isoenzymes in Liver and Adipose Tissue of Man and Dog

1967 • 54 citations

Tissue Glycolytic and Gluconeogenic Enzyme Activities in Mildly and Moderately Diabetic Rats: Influence of Tolbutamide Administration

1974 • 54 citations

Electrophoretic properties and tissue distribution of multiple forms of hexokinase in various mammalian species

1966 • 54 citations

Glucose metabolism in the mucosa of the small intestine. A study of hexokinase activity

1968 • 53 citations

Hepatic Enzyme Activities of Glycolysis and Gluconeogenesis in Diabetes of Man and Laboratory Animals

1970 • 53 citations

Regulation of development of hepatic glucokinase in the neonatal rat by the diet

1967 • 53 citations

The Effect of N-Acetylglucosamine and Glucosamine on Carbohydrate Metabolism in Rat Liver Slices

1958 • 52 citations

Hexose-ATP phosphotransferases: Comparative aspects

1968 • 49 citations

Dietary control of liver glucokinase activity in the normal rat

1964 • 49 citations

Studies on the use of sepharose-N-(6-aminohexanoyl)-2-amino-2-deoxy-D-glucopyranose for the large-scale purification of hepatic glucokinase

1976 • 49 citations

The Preparation and Characterization of Pure Rat Liver Glucokinase

1974 • 47 citations

Glucose (Hexose 6-Phosphate) Dehydrogenase in Liver of Rainbow Trout

1971 • 46 citations

Distribution of hexokinase and glucokinase between parenchymal and non‐parenchymal cells of rat liver

1969 • 46 citations

Age-Dependent Regulation of Glucokinase and Tyrosine Aminotransferase Activities of Rat Liverin Vivoby Adrenal, Pancreatic and Pituitary Hormones

1972 • 45 citations

Hepatic Glucose Phosphotransferases Variations Among Species

1966 • 43 citations

Effect of Insulin on the Synthesisin Vitroof Hexokinase in Rat Epididymal Adipose Tissue

1970 • 43 citations

The effects of glucagon and insulin on adenosine 3′:5′-cyclic monophosphate concentrations in an organ culture of mature rat liver

1973 • 42 citations

STUDIES ON CARBOHYDRATE METABOLISM IN RAT LIVER SLICES

1958 • 42 citations

Activities and isoenzyme patterns of some enzymes of glucose metabolism in human primary malignant hepatoma.

1973 • 42 citations

Rat hepatic glucokinase: Improved purification and some properties

1972 • 41 citations

Embryonic Origin of Human Tumor-Specific Antigens

2015 • 40 citations

Liver Glucokinase Induction in Acute and Chronic Insulin Insufficiency in Rats

1967 • 40 citations

Inhibition by Catecholamines of the Induction of Rat Liver Glucokinase

1970 • 39 citations

Effect of alloxan-diabetes on the glucose-ATP phosphotransferase activity of adipose tissue

1966 • 38 citations

On para‐endocrine cancer syndromes

1969 • 38 citations

Studies on the Mode of Action of Insulin: Properties and Biological Activity of an Insulin-Dextran Complex

1972 • 37 citations

Studies on factors affecting the induction of ATP d-hexose 6-phosphotransferase in rat liver

1965 • 37 citations

Premature Induction of Glucokinase in the Neonatal Rat by Thyroid Hormone

1975 • 37 citations

Pyruvate kinase, hexokinase, and aldolase isozymes in rat liver cells in culture

1972 • 37 citations

Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo

1973 • 37 citations

Studies on the liver catalase of normal and cancerous rats

1948 • 37 citations

The kinetic quantitation of ATP: D‐glucose 6‐phosphotransferases

1972 • 34 citations

Comparison of ability of Mg and Mn to activate the key enzymes of glycolysis

1972 • 31 citations

THE EFFECT OF INSULIN AND ADRENAL CORTICAL EXTRACT ON THE HEXOKINASE REACTION IN EXTRACTS OF MUSCLE FROM DEPANCREATIZED CATS

1950 • 30 citations

Glucose metabolism in the mucosa of the small intestine. The effect of glucose on hexokinase activity

1969 • 29 citations

Isozymes and enzyme regulation in cancer

1972 • 29 citations

Effects of hydroxyurea and 6-mercaptopurine on growth and some aspects of carbohydrate metabolism in regenerating and neoplastic liver.

1970 • 28 citations

Glucose metabolism in the mucosa of the small intestine. Changes of hexokinase activity during perfusion of the proximal half of rat small intestine

1970 • 28 citations

Resolution of two ATP:D-hexose 6-phosphotransferase bands by starch-gel electrophoresis

1968 • 27 citations

The inhibition of rat liver glucokinase by palmitoyl-CoA

1969 • 25 citations

Inhibition of pyruvate kinase and glucokinase by acetyl CoA and inhibition of glucokinase by phosphoenolpyruvate

1967 • 25 citations

Inhibition of Glucose Use in Muscle Extracts by Lipoproteins

1954 • 25 citations

Adaptable glucokinase activity of human liver

1970 • 24 citations

Isolation and Properties of Intestinal Hexokinases, Fructokinase, and N-Acetylglucosamine Kinase

1971 • 24 citations

Glucokinase activities and glycogen contents of livers of normal and hypophysectomized, X-irradiated rats subjected to different nutritional treatments

1964 • 22 citations

Occurrence and Function of a High‐K_m Hexokinase in Immature Red Blood Cells

1970 • 22 citations

Comparative studies on glucose phosphorylating isoenzymes of vertebrates. III

1972 • 22 citations

The effect of hypophysectomy on rat liver gluocokinase activity and on plasma glucose, insulin and nonesterified fatty acid concentrations

1969 • 21 citations

[Isoenzymes and cancer].

1970 • 21 citations

The Expression Of Normal Histocompatibility Antigens In Tumor Cells

1973 • 21 citations

Hormonal regulation of liver hexokinase activity

1964 • 21 citations

Hepatic Glucokinase: A Direct Effect of Insulin

1963 • 20 citations

Comparative studies on glucose phosphorylating isoenzymes of vertebrates—II. Chromatographic patterns of glucokinase and hexokinases in the liver of rodents

1971 • 20 citations

Glucose-6-Phosphatase and the Exchange of Glucose with Glucose-6-Phosphate

1960 • 20 citations

Glucose-phosphorylating Enzyme with High Km in Human Brain

1967 • 20 citations

Hexokinase Activity of Rat Intestinal Mucosa: Demonstration of Four Isozymes and of Changes in Subcellular Distribution with Fasting and Refeeding

1973 • 19 citations

Insulin preservation of glucokinase activity in isolated perfused rat liver

1967 • 19 citations

Glucose-adenosine 5′-triphosphate 6-phosphotransferases of isolated rat liver parenchymal cells

1972 • 18 citations

Effect of Acute Insulin Deprivation on Rat Liver Glucokinase

1968 • 17 citations

Early changes in the levels of liver glycolytic enzymes after total pancreatectomy in the rat

1971 • 16 citations

INSULIN, ADENYL CYCLATE, IONS, AND THE HEART

1974 • 15 citations

Inhibition of enzymes by lipoproteins

1956 • 15 citations

Hexokinase in isolated epithelial cells from rat intestine

1973 • 14 citations

Immunochemical titration of liver glucokinase from normal, fasted, and diabetic rats

1974 • 14 citations

The topographical location and unique nature of a glucokinase associated with the Golgi apparatus of rat liver

1976 • 14 citations

Hexokinase and glucokinase activities in bile duct epithelial cells and hepatic cells from normal rat and human livers

1967 • 14 citations

The effect of glucose ingestion on basal and induced enzyme levels in rat tissues

1973 • 13 citations

Induction of key glycolytic enzymes in mouse fetal liver cultured in circumfusion system by insulin

1973 • 12 citations

The protective effect of estradiol-17 beta against polycyclic hydrocarbon cytotoxicity.

1973 • 11 citations

Identification of Human Hepatic Glucokinase and Some Properties of the Enzyme

1968 • 11 citations

Effects of manganese on the activity of glycolytic and gluconeogenic enzymes in the perfused rat liver

1973 • 11 citations

Carbohydrate metabolism in pancreatic islets and the release of insulin

1969 • 9 citations

Fetal development of the multiple forms of rat hexokinase

1972 • 9 citations

The relationship of some rat liver glycolytic enzyme activities to plasma insulin concentration

1968 • 9 citations

The Effects of Thyroid State on Rat Liver Hexokinase Isozymes

1972 • 7 citations

Hepatic hexokinase isozyme in liver diseases

1974 • 6 citations

Streptozotocin-Induced Diabetes and Regulation of Hepatic Glucose Metabolism

1971 • 6 citations

A significant strain difference in “biochemical aging” of rats

1973 • 5 citations

Lack of Effect of Insulin and Blood Fractions on Glucose-ATP Phosphotransferases.

1966 • 5 citations

Synthesis of glucose 6-phosphate by a 1,3-diphosphoglycerate-glucose phosphotransferase activity of liver microsomes

1973 • 4 citations

Response of Hepatic Enzyme Activities to Castration and Sarcoma 37 Growth in Different Mouse Genotypes&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1972 • 4 citations

Enzymes of carbohydrate and amino acid metabolism in liver, brain and kidney ofMacaca mulatta

1971 • 4 citations