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NMRPipe: A multidimensional spectral processing system based on UNIX pipes

1995 • 15,623 citations

The Principles of Nuclear Magnetism

1961 • 14,411 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Principles of Nuclear Magnetism

1993 • 2,357 citations

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1994 • 2,051 citations

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1996 • 1,680 citations

Data Analysis and Regression: A Second Course in Statistics

1977 • 1,577 citations

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2001 • 894 citations

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2004 • 829 citations

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2003 • 691 citations

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1995 • 528 citations

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1993 • 448 citations

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2003 • 428 citations

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2002 • 360 citations

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1995 • 328 citations

Pathways of ubiquitin conjugation

1997 • 309 citations

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2001 • 283 citations

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2001 • 280 citations

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1996 • 275 citations

Automated prediction of 15N, 13Calpha, 13Cbeta and 13C' chemical shifts in proteins using a density functional database.

2001 • 272 citations

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1970 • 260 citations

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1998 • 250 citations

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1996 • 240 citations

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2002 • 179 citations

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2001 • 164 citations

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2004 • 158 citations

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1992 • 157 citations

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2002 • 148 citations

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2003 • 142 citations

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1994 • 141 citations

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1998 • 138 citations

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1999 • 134 citations

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1998 • 129 citations

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1998 • 119 citations

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2001 • 104 citations

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1999 • 92 citations

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1999 • 92 citations

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1994 • 86 citations

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2000 • 84 citations

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1998 • 77 citations

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2001 • 77 citations

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2004 • 68 citations

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1999 • 60 citations

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2003 • 52 citations

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2000 • 42 citations

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1999 • 40 citations

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2002 • 35 citations

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2002 • 34 citations

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2000 • 29 citations

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2004 • 29 citations

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2004 • 27 citations