Phosphorylation of Jak2 on Ser₅₂₃ InhibitsJak2-Dependent Leptin ReceptorSignaling

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS

2003 • 1,701 citations

The Leptin Receptor

1997 • 1,300 citations

The Role of Hemocytes in <b><i>Anopheles gambiae</i></b> Antiplasmodial Immunity

2013 • 1,046 citations

Activation of Downstream Signals by the Long Form of the Leptin Receptor

2000 • 800 citations

Cytokines and autoimmunity

2002 • 663 citations

Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

2001 • 577 citations

Molecular and anatomical determinants of central leptin resistance

2005 • 543 citations

SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

2000 • 531 citations

The Function of Leptin in Nutrition, Weight, and Physiology

2002 • 512 citations

Leptin Receptor Signaling and the Regulation of Mammalian Physiology

2004 • 458 citations

Obesity and the Hypothalamus: Novel Peptides for New Pathways

1998 • 448 citations

Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y¹⁰⁰⁷ in the Kinase Activation Loop

1997 • 343 citations

Signaling pathways activated by the growth hormone receptor

2001 • 326 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

The Pseudokinase Domain Is Required for Suppression of Basal Activity of Jak2 and Jak3 Tyrosine Kinases and for Cytokine-inducible Activation of Signal Transduction

2002 • 309 citations

Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling.

1994 • 305 citations

Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways

1997 • 248 citations

The Principal Rapamycin-Sensitive p70^s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

1996 • 245 citations

Regulation of Jak Kinases by Intracellular Leptin Receptor Sequences

2002 • 228 citations

Role of IRS-1-GRB-2 complexes in insulin signaling.

1994 • 215 citations

Signaling by Type I and II cytokine receptors: ten years after

2001 • 206 citations

Regions of the JAK2 Tyrosine Kinase Required for Coupling to the Growth Hormone Receptor

1995 • 176 citations

Feedback Inhibition of Leptin Receptor/Jak2 Signaling via Tyr1138 of the Leptin Receptor and Suppressor of Cytokine Signaling 3

2004 • 155 citations

Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction

1995 • 148 citations

The Amino-terminal Portion of the JAK2 Protein Kinase Is Necessary For Binding and Phosphorylation of the Granulocyte-Macrophage Colony-stimulating Factor Receptor β Chain

1995 • 148 citations

Autophosphorylation of JAK2 on Tyrosines 221 and 570 Regulates Its Activity

2004 • 141 citations

Unexpected Effects of FERM Domain Mutations on Catalytic Activity of Jak3

2001 • 139 citations

Signaling by the Cytokine Receptor Superfamily^a

1998 • 119 citations

Tyrosine Phosphorylation of Jak2 in the JH2 Domain Inhibits Cytokine Signaling

2004 • 112 citations

Tyrosine 813 Is a Site of JAK2 Autophosphorylation Critical for Activation of JAK2 by SH2-Bβ

2004 • 110 citations

A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling

2000 • 97 citations

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7

2002 • 90 citations

Protein kinase-c activation inhibits tyrosine phosphorylation of the c-met protein.

1990 • 70 citations

Phosphorylation of JAK2 at Serine 523: a Negative Regulator of JAK2 That Is Stimulated by GrowthHormone and Epidermal Growth Factor

2006 • 57 citations

Role of IRS-l-GRB-2 Complexes in Insulin Signaling

1994 • 41 citations

Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3–dependent myeloid progenitor cells

2000 • 41 citations

Mutations in the Conserved C-Terminal Sequence in Thyroid Hormone Receptor Dissociate Hormone-Dependent Activation from Interference with AP-1 Activity

1997 • 40 citations