Quantitative Structure-Activity Relationship of Multidrug Resistance Reversal Agents

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Structure-Based Strategies for Drug Design and Discovery

1992 • 972 citations

Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm

1989 • 943 citations

A Southwest Oncology Group study

1993 • 778 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Weakly Polar Interactions In Proteins

1988 • 724 citations

Artificial intelligence approach to structure-activity studies. Computer automated structure evaluation of biological activity of organic molecules

1984 • 421 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

Cell biological mechanisms of multidrug resistance in tumors.

1994 • 377 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

1994 • 334 citations

MULTICASE 1. A Hierarchical Computer Automated Structure Evaluation Program

1992 • 313 citations

The anticancer drugs

1979 • 289 citations

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance.

1989 • 233 citations

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1989 • 217 citations

Taxane Anticancer Agents

1994 • 189 citations

Clinical Studies with Modulators of Multidrug Resistance

1995 • 163 citations

P-glycoprotein as multidrug transporter: a critical review of current multidrug resistant cell lines

1992 • 157 citations

A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. A southwest oncology group study

1995 • 155 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Transmembrane Aromatic Amino Acid Distribution in P-glycoprotein

1994 • 116 citations

Reversal of multidrug resistance by phenothiazines and structurally related compounds

1992 • 114 citations

Rational design and pre-clinical pharmacology of drugs for reversing multidrug resistance

1992 • 86 citations

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1989 • 86 citations

Modulators of Multidrug Resistance: Preclinical Studies

1995 • 78 citations

Structural characteristics of compounds that modulate P-glycoprotein-associated multidrug resistance

1990 • 78 citations

New triazine derivatives as potent modulators of multidrug resistance

1992 • 76 citations

Reversal by cefoperazone of resistance to etoposide, doxorubicin, and vinblastine in multidrug resistant human sarcoma cells.

1989 • 74 citations

Reversal of multidrug resistance by lipophilic drugs.

1990 • 73 citations

The nitrogen of the acetamido group of colchicine modulates P-glycoprotein-mediated multidrug resistance

1993 • 59 citations

Preclinical and Clinical Modulation of Anticancer Drugs

1993 • 58 citations

Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.

1989 • 56 citations

Design and tumor targeting of anthracyclines able to overcome multidrug resistance: A double-advantage approach

1993 • 56 citations

Reversal of resistance to vincristine in P388 leukemia by various polycyclic clinical drugs, with a special emphasis on quinacrine.

1988 • 55 citations

Computer simulation of physical-chemical properties of organic molecules. 1. Molecular system identification

1981 • 54 citations

The role of drug-lipid interactions in the biological activity of modulators of multi-drug resistance

1993 • 53 citations

Circumvention of adriamycin resistance by dipyridamole analogues: A structure‐activity relationship study

1989 • 52 citations

Multidrug resistance: clinical relevance in acute leukemia.

1993 • 49 citations

Structural Determinants of Phenoxazine Type Compounds Required to Modulate the Accumulation of Vinblastine and Vincristine in Multidrug-Resistant Cell Lines

1990 • 47 citations

Activities of newly synthesized dihydropyridines in overcoming of vincristine resistance, calcium antagonism, and inhibition of photoaffinity labeling of P-glycoprotein in rodents.

1990 • 45 citations

Structure-activity study and design of multidrug-resistant reversal compounds by a computer automated structure evaluation methodology.

1992 • 41 citations

New Potent Verapamil Derivatives that Reverse Multidrug Resistance in Human Renal Carcinoma Cells and in Transgenic Mice Expressing the Human MDR 1 Gene

1991 • 36 citations

Reversal of multidrug resistance by a new lipophilic cationic molecule, S9788. Comparison with 11 other MDR-modulating agents in a model of doxorubicin-resistant rat glioblastoma cells

1993 • 33 citations

Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells

1992 • 32 citations

Diversity of multidrug resistance in mammalian cells.

1994 • 30 citations

Structural requirements of simple organic cations for recognition by multidrug-resistant cells.

1992 • 27 citations

Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists.

1994 • 26 citations

Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds

1994 • 26 citations

Use of the Extreme Drug Resistance Assay to Evaluate Mechanisms of Resistance in Ovarian Cancer: Taxol Resistance and MDR-1 Expression

1994 • 23 citations

In vitro evaluation of chemosensitizers for clinical reversal of P-glycoprotein-associated Taxol resistance.

1993 • 20 citations

Reversal of P-glycoprotein-associated multidrug resistance: The challenge continues

1993 • 20 citations

Derivatives of a Novel Cyclopeptolide. 2. Synthesis, Activity against Multidrug Resistance in CHO and KB Cells in vitro, and Structure-Activity Relationships

1994 • 13 citations

The Challenge Continues

1995 • 8 citations

Resistance to Lipophilic Cationic Compounds in Multidrug Resistant Leukemia Cells

1993 • 7 citations

ChemInform Abstract: Derivatives of a Novel Cyclopeptolide. Part 2. Synthesis, Activity Against Multidrug Resistance in CHO and KB Cells in vitro, and Structure‐Activity Relationships.

1994 • 6 citations