Antiproteinuric Therapy while Preventing the Abnormal Protein Traffic in Proximal Tubule Abrogates Protein- and Complement-Dependent Interstitial Inflammation in Experimental Renal Disease

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein

1981 • 1,422 citations

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

1990 • 1,378 citations

Pathophysiology of Progressive Nephropathies

1998 • 1,250 citations

Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension.

1986 • 1,210 citations

Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass.

1985 • 931 citations

Understanding the nature of renal disease progression

1997 • 655 citations

Renal injury from angiotensin II-mediated hypertension.

1992 • 546 citations

Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.

1985 • 482 citations

Structural-functional correlations in renal disease

1970 • 458 citations

The Regulators of Complement Activation (RCA) Gene Cluster

1989 • 442 citations

Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kB activation

1998 • 415 citations

Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass

1982 • 355 citations

Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein.

1997 • 321 citations

The Pathogenesis of Chronic Renal Failure in Diabetic Nephropathy

1991 • 284 citations

Interstitial nephritis induced by protein-overload proteinuria.

1989 • 283 citations

Cross sectional longitudinal study of spot morning urine protein:creatinine ratio, 24 hour urine protein excretion rate, glomerular filtration rate, and end stage renal failure in chronic renal disease in patients without diabetes

1998 • 260 citations

Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in the rat.

1990 • 255 citations

Proximal tubular cell synthesis and secretion of endothelin-1 on challenge with albumin and other proteins

1995 • 246 citations

In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation.

1998 • 242 citations

Influence of Clinical and Histological Features on Actuarial Renal Survival in Adult Patients With Idiopathic IgA Nephropathy, Membranous Nephropathy, and Membranoproliferative Glomerulonephritis: Survey of the Recent Literature

1992 • 187 citations

Interleukin 2 mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells.

1991 • 184 citations

Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties

1981 • 184 citations

Tubulo-interstitial lesions mediate renal damage in adriamycin glomerulopathy

1986 • 180 citations

Renal proximal tubular AT2 receptor: signaling and transport.

1999 • 179 citations

Localization of the complement regulatory proteins in the normal human kidney

1994 • 158 citations

Long-term prognosis of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changes.

1989 • 155 citations

Long-term prognosis of focal sclerosing glomerulonephritis. An analysis of 250 cases with particular regard to tubulointerstitial changes.

1990 • 151 citations

Alternative pathway activation of complement by cultured human proximal tubular epithelial cells

1994 • 143 citations

Combining an Antiproteinuric Approach with Mycophenolate Mofetil Fully Suppresses Progressive Nephropathy of Experimental Animals

1999 • 140 citations

Mechanisms underlying transition from acute glomerular injury to late glomerular sclerosis in a rat model of nephrotic syndrome.

1988 • 130 citations

Characterization and distribution of interstitial cell types in the renal cortex of rats

1994 • 114 citations

Age-related nephropathy and proteinuria in rats with intact kidneys exposed to diets with different protein content.

1989 • 105 citations

Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis.

1997 • 104 citations

New immunologically non-specific immunosuppressive agents dictate changes in standard protocols for renal transplant management.

1997 • 103 citations

The role of complement in the pathogenesis of tubulointerstitial lesions in rat mesangial proliferative glomerulonephritis.

1997 • 79 citations

The consequences for renal function of widening of the interstitium and changes in the tubular epithelium of the renal cortex and outer medulla in various renal diseases.

1992 • 67 citations

Effect of low-dose enalapril on glomerular size-selectivity in human diabetic nephropathy

1993 • 66 citations

In vitro alternative pathway activation of complement by the brush border of proximal tubules of normal rat kidney.

1982 • 60 citations

Immunoelectron Microscopic Demonstration of Thy-1 Antigen on the Surfaces of Mesangial Cells in the Rat Glomerulus

1986 • 53 citations

In vivo localization of C3 on the brush border of proximal tubules of kidneys from nephrotic patients.

1985 • 48 citations

Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney

1998 • 48 citations

Location of gp330/alpha 2-m receptor-associated protein (alpha 2-MRAP) and its binding sites in kidney: distribution of endogenous alpha 2-MRAP is modified by tissue processing.

1993 • 43 citations

Glomerular manifestations of diabetes in the BB rat

1983 • 41 citations

Tubulointerstitial lesions in human membranous glomerulonephritis: Relationship to proteinuria

1995 • 41 citations

Glomerular protein trafficking and progression of renal disease to terminal uremia.

1996 • 40 citations

Passive Heymann nephritis: evidence that angiotensin-converting enzyme inhibition reduces proteinuria and retards renal structural injury.

1996 • 40 citations

Contribution on the correlation between morphometric parameters gained from the renal cortex and renal function in IgA nephritis.

1988 • 34 citations

Biochemistry of C3 and Related Thiolester Proteins in Infection and Inflammation

1987 • 31 citations

Intraglomerular C3 synthesis in rats with passive Heymann nephritis.

1997 • 24 citations

Renin Secretion by the Spontaneously Diabetic Rat

1986 • 20 citations

Cited By (0)

Loading...