Immunohistochemical analysis of atypical ductular reaction in the human liver, with special emphasis on the presence of growth factors and their receptors

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers.

1991 • 334 citations

Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions.

1992 • 327 citations

Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture

1985 • 325 citations

Expression of hepatocyte growth factor gene in endothelial and kupffer cells of damaged rat livers, as revealed by insitu hydridization

1990 • 299 citations

Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man

1998 • 288 citations

Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat.

1994 • 285 citations

Serum hepatocyte growth factor levels in liver diseases: Clinical implications

1995 • 202 citations

Ductular Reaction in the Livers

1995 • 183 citations

Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: Identification of a human hepatic progenitor cell?

1999 • 173 citations

Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse.

1994 • 168 citations

Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor.

1992 • 141 citations

Comparison of liver progenitor cells in human atypical ductular reactions with those seen in experimental models of liver injury

1998 • 138 citations

Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6.

1998 • 135 citations

Ductular cell reaction in the liver in hepatic injury.

1957 • 134 citations

Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes.

1990 • 133 citations

Partial cloning of rat CD34 cDNA and expression during stem cell- dependent liver regeneration in the adult rat

1997 • 126 citations

Ductular reaction after submassive necrosis in humans. Special emphasis on analysis of ductular hepatocytes.

1996 • 124 citations

Ultrastructural characteristics of novel epithelial cell types identified in human pathologic liver specimens with chronic ductular reaction.

1992 • 122 citations

Expression of transforming growth factor‐alpha in regenerating liver and during hepatic differentiation

1992 • 114 citations

‘Undifferentiated progenitor cells’ in focal nodular hyperplasia of the liver

1996 • 113 citations

The gene of hepatocyte growth factor is expressed in fat-storing cells of rat liver and is downregulated during cell growth and by transforming growth factor-β

1992 • 109 citations

Hepatic Stem Cell Compartment: Activation and Lineage Commitment

1993 • 104 citations

Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type i ductular reaction in mice: Interactions between the periductal inflammatory and stromal cells and the biliary epithelium

1998 • 102 citations

Identification of bipotential progenitor cells in human liver regeneration.

1996 • 98 citations

Phenotypic characterization of hepatic proliferation. Antigenic expression by proliferating epithelial cells in fetal liver, massive hepatic necrosis, and nodular transformation of the liver.

1983 • 98 citations

Significance of serum human hepatocyte growth factor levels in patients with hepatic failure

1992 • 90 citations

The Nature and Origin of Proliferated Bile Ductules in Alcoholic Liver Disease

1983 • 84 citations

Primary liver tumour of intermediate (hepatocyte—bile duct cell) phenotype: a progenitor cell tumour?

1998 • 82 citations

Coexpression of Stem Cell Factor andc-kitin Embryonic and Adult Liver

1996 • 75 citations

Nodules of less-differentiated tumor within or adjacent to hepatocellular carcinoma: Relative expression of transforming growth factor-α and its receptor in the different areas of tumor

1995 • 75 citations

Role of C-kitreceptor tyrosine kinase in development of oval cells in the rat 2-acetylaminofluorene/partial hepatectomy model

1999 • 73 citations

Liver stem cells**The colour plate section for this chapter appears between pages 274 and 275.

1997 • 73 citations

Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study

1999 • 72 citations

CANCER BIOLOGY: Expression of transforming growth factor alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met and acidic fibroblast growth factor/fibroblast growth factor receptors during hepatocarcinogenesis

1996 • 72 citations

The development of proliferating ductular structures in liver disease. An immunohistochemical study.

1990 • 67 citations

Characterization of ductular hepatocytes in end-stage cirrhosis.

1990 • 65 citations

Role of TGF‐Beta in Normal Differentiation and Oncogenesis in Rat Liver

1989 • 61 citations

Expression of hepatitis B surface and core antigens and transforming growth factor‐a in “oval cells” of the liver in patients with hepatocellular carcinoma

1994 • 57 citations

Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver

1995 • 57 citations

Parenchymal and Nonparenchymal Cell Interactions in the Liver

1993 • 55 citations

A cytokeratin‐immunohistochemical study of focal nodular hyperplasia of the liver: further evidence that ductular metaplasia of hepatocytes contributes to ductular “proliferation”

1989 • 44 citations

Normal and Abnormal Development of the Human Intrahepatic Biliary System: A Review.

1997 • 44 citations

Cell‐kinetic study of proliferating bile ductules in various hepatobiliary diseases

1998 • 42 citations

Bile ductule formation in fetal, neonatal, and infant livers compared with extrahepatic biliary atresia

1996 • 42 citations

Modulation of the plasminogen activator/plasmin system in rat liver regenerating by recruitment of oval cells.

1998 • 39 citations

AFP‐PRODUCING CELLS IN HEPATITIS AND IN LIVER CIRRHOSIS

1975 • 36 citations

Morphometric and immunohistochemical characterization of human liver regeneration.

1995 • 34 citations

The relation of mesenchymal cell products to hepatic epithelial systems.

1990 • 31 citations

Characterization of ductular hepatocytes in primary liver allograft failure.

1997 • 30 citations

Distortion in TGFβ1 peptide immunolocalization in biliary atresia: Comparison with the normal pattern in the developing human intrahepatic bile duct system

1995 • 24 citations

Expression of transforming growth factor-? in hepatoblastoma

1998 • 22 citations

Eurohep

1992 • 22 citations

Monoclonal anti cytokeratin antibodies reveal bile duct origin of cirrhotic ductular proliferations (dp)

1985 • 12 citations

Expression of HBs- and HBc-antigen in neoductular epithelium in chronic active hepatitis B

1993 • 11 citations