Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

Cancer Cell Cycles

1996 • 5,379 citations

Correlation of Computed Tomography and Positron Emission Tomography in Patients With Metastatic Gastrointestinal Stromal Tumor Treated at a Single Institution With Imatinib Mesylate: Proposal of New Computed Tomography Response Criteria

2007 • 1,438 citations

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

2003 • 1,418 citations

Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

2006 • 1,180 citations

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

2000 • 1,092 citations

The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients

2004 • 862 citations

IL-10, IL-6, and TNF-α: Central factors in the altered cytokine network of uremia—The good, the bad, and the ugly

2005 • 856 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo

2000 • 742 citations

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

2000 • 572 citations

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

2008 • 499 citations

Phase II Trial of Intratumoral Administration of ONYX-015, a Replication-Selective Adenovirus, in Patients With Refractory Head and Neck Cancer

2001 • 467 citations

RECIST revisited: A review of validation studies on tumour assessment

2006 • 418 citations

A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy.

2001 • 380 citations

Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

2001 • 345 citations

Oncolytic viruses in cancer therapy

2007 • 332 citations

Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints.

2002 • 308 citations

Clinical Trials with Oncolytic Adenovirus in China

2007 • 258 citations

Acute Toxicity After High-Dose Systemic Injection of Helper-Dependent Adenoviral Vectors into Nonhuman Primates

2004 • 245 citations

A Phase I Trial of Intravenous CG7870, a Replication-Selective, Prostate-Specific Antigen–Targeted Oncolytic Adenovirus, for the Treatment of Hormone-Refractory, Metastatic Prostate Cancer

2006 • 236 citations

Gene Transfer to Ovarian Cancer Versus Normal Tissues with Fiber-Modified Adenoviruses

2002 • 185 citations

Phase I–II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas

2005 • 168 citations

Adenovirus Type 5 Interactions with Human Blood Cells May Compromise Systemic Delivery

2006 • 154 citations

Phase I Trial of Replication-competent Adenovirus-mediated Suicide Gene Therapy Combined with IMRT for Prostate Cancer

2007 • 143 citations

Cytokines in adenoviral disease in children: Association of interleukin-6, interleukin-8, and tumor necrosis factor alpha levels with clinical outcome

1994 • 141 citations

CYTOKINE VARIATIONS IN PATIENTS WITH HORMONE TREATED PROSTATE CANCER

2000 • 141 citations

Clinical Significance of Serum Cytokine Measurements in Untreated Colorectal Cancer Patients: Soluble Tumor Necrosis Factor Receptor Type I – An Independent Prognostic Factor

2005 • 107 citations

Serum Concentrations of Cytokines and Lung Cancer Survival in African Americans and Caucasians

2009 • 107 citations

A phase I trial of intravenous infusion of ONYX-015 and enbrel in solid tumor patients

2007 • 84 citations

Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer

2008 • 80 citations

Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

2010 • 70 citations

Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism

2003 • 69 citations

RECIST vs. WHO: Prospective comparison of response criteria in an EORTC phase II clinical trial investigating ET-743 in advanced soft tissue sarcoma

2005 • 58 citations

Fiber‐knob modifications enhance adenoviral tropism and gene transfer in malignant glioma

2007 • 55 citations

Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

2008 • 48 citations

Infectivity-Enhanced Adenoviruses Deliver Efficacy in Clinical Samples and Orthotopic Models of Disseminated Gastric Cancer

2006 • 48 citations

Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer

2004 • 43 citations

Oncolytic viruses from the perspective of the immune system

2009 • 43 citations

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

2009 • 43 citations

Oncolytic adenovirus treatment of a patient with refractory neuroblastoma

2010 • 35 citations

Live viruses in cancer treatment.

2002 • 27 citations

E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer

2008 • 22 citations

A demand for next-generation oncolytic adenoviruses.

2006 • 18 citations