Human Prorenin Has “Gate and Handle” Regions for Its Non-proteolytic Activation

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,265 citations

Methods in Immunology and Immunochemistry

1967 • 1,145 citations

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin

2002 • 1,096 citations

Increased Plasma Inactive Renin in Diabetes Mellitus

1985 • 339 citations

Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke Basel Prospective Study

1993 • 328 citations

Cloning and sequence analysis of cDNA for human renin precursor.

1983 • 266 citations

Inactive renin in human plasma.

1976 • 131 citations

Human prorenin.

1991 • 108 citations

INACTIVE RENIN IN HUMAN PLASMA

1976 • 96 citations

Isolation and characterization of native human renin derived from Chinese hamster ovary cells

1986 • 91 citations

Structure of the rat renin gene

1988 • 85 citations

"Prorenin" in human plasma?

1975 • 83 citations

Molecular cloning and nucleotide sequence of a human renin cDNA fragment

1983 • 79 citations

Two-step prorenin-renin conversion. Isolation of an intermediary form of activated prorenin.

1987 • 76 citations

Prorenin as a reproductive hormone. New form of the renin system

1986 • 75 citations

Reversible cryoactivation of recombinant human prorenin.

1992 • 74 citations

Reversible activation–inactivation of renin in human plasma

1980 • 71 citations

Nonproteolytic “activation” of prorenin by active site-directed renin inhibitors as demonstrated by renin-specific monoclonal antibody

1992 • 62 citations

Inhibition of human renin by synthetic peptides derived from its prosegment.

1985 • 61 citations

A Structural Model to Explain the Partial Catalytic Activity of Human Prorenin

1989 • 58 citations

Molecular Analysis of Human Prorenin Prosegment Variants in Vitro and in Vivo

1995 • 53 citations

Molecular biology of renin I: Gene and protein structure, synthesis and processing

1992 • 36 citations

The Dominant Role of the Prosegment of Prorenin in Determining the Rate of Activation by Acid or Trypsin: Studies with Molecular Chimeras

2000 • 29 citations

Site-Directed Mutagenesis of Human Prorenin. Substitution of Three Arginine Residues in the Propeptide with Glutamine Residues Yields Active Prorenin1

1990 • 26 citations

The molecular biology of human renin and its gene.

1989 • 25 citations

Renin in Wilms' tumor: prorenin as an indicator.

1994 • 22 citations

Renin-angiotensin system components and endothelial proteins as markers of diabetic microvascular disease

1993 • 22 citations

Purification of renin and prorenin.

1991 • 17 citations

Protein modeling of human prorenin using the molecular dynamics method

1990 • 16 citations

Pathophysiological Significance of Plasma Total Renin and Prorenin in Patients with Diabetes Mellitus.

1995 • 15 citations

Molecular cloning of complementary DNA to swine pepsinogen mRNA.

1981 • 15 citations

Proteolytic and Non-Proteolytic Activation of Prorenin

1998 • 10 citations

Non-proteolytic Activation of Human Prorenin by Anti-prorenin Prosegment (pf#1: 1P-15P) Antiserum

1999 • 7 citations

<b>A MICROPLATE ENZYME-LINKED IMMUNOSORBENT ASSAY SYSTEM FOR HUMAN RENIN USING 3,3’,5,5’-</b><b>TETRAMETHYLBENZIDINE: AN APPLICATION TO HUMAN RENIN AND PRORENIN STUDY</b>

1992 • 6 citations

Processing and sorting of human prorenin

1991 • 3 citations