GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding.

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum

1982 • 766 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane

1986 • 509 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle

1989 • 474 citations

Dissociation of Mammalian Polyribosomes into Subunits by Puromycin

1971 • 432 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP–binding domains

1989 • 357 citations

Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.

1986 • 337 citations

The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle

1986 • 336 citations

In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent post-translational translocation of the prepro-α-factor

1986 • 332 citations

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1989 • 293 citations

An E. coli Ribonucleoprotein Containing 4.5 S RNA Resembles Mammalian Signal Recognition Particle

1990 • 285 citations

The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence.

1990 • 256 citations

Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: Analysis of biochemical mutants of SRP

1988 • 248 citations

Disassembly and reconstitution of signal recognition particle

1983 • 242 citations

Requirement of GTP Hydrolysis for Dissociation of the Signal Recognition Particle from Its Receptor

1991 • 222 citations

Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein.

1986 • 199 citations

The signal recognition particle receptor is a complex that contains two distinct polypeptide chains.

1986 • 189 citations

Elongation arrest is not a prerequisite for secretory protein translocation across the microsomal membrane.

1985 • 179 citations

Translocation of proteins across the endoplasmic reticulum

1993 • 176 citations

Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact

1986 • 176 citations

The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain.

1990 • 170 citations

[53] Signal recognition particle: A ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties

1983 • 155 citations

The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences.

1992 • 149 citations

Signal recognition particle mediates a transient elongation arrest of preprolactin in reticulocyte lysate.

1989 • 148 citations

The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length.

1988 • 106 citations

The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle.

1991 • 101 citations

Assembly of the Alu domain of the signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA.

1990 • 85 citations

The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation

1992 • 78 citations

Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe.

1983 • 77 citations

Assembly of the Alu Domain of the Signal Recognition Particle (SRP): Dimerization of the Two Protein Components Is Required for Efficient Binding to SRP RNA

1990 • 40 citations

Cited By (0)

Loading...