Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

1997 • 1,108 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome

1990 • 687 citations

Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation

1986 • 660 citations

Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae

1997 • 586 citations

Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase

1997 • 477 citations

Biological effects of diesel exhaust particles. I. in vitro production of superoxide and in vivo toxicity in mouse

1993 • 362 citations

Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

1997 • 350 citations

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA

1987 • 343 citations

Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

1997 • 328 citations

A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

1997 • 316 citations

Comparative Pulmonary Toxicities and Carcinogenicities of Chronically Inhaled Diesel Exhaust and Carbon Black in F344 Rats

1995 • 291 citations

Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage

1997 • 258 citations

Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation

1987 • 257 citations

Health Effects of Exposure to Diesel Exhaust Particles

1987 • 254 citations

Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking.

1996 • 253 citations

Pulmonary Inflammatory, Chemokine, and Mutagenic Responses in Rats after Subchronic Inhalation of Carbon Black

1996 • 222 citations

Lung carcinogenesis and formation of 8-hydroxy-deoxyguanosine in mice by diesel exhaust particles

1997 • 205 citations

Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice

1996 • 199 citations

Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells.

1993 • 189 citations

c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions.

1992 • 188 citations

Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue

1995 • 160 citations

Global Increases in Allergic Respiratory Disease: the Possible Role of Diesel Exhaust Particles

1996 • 155 citations

Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase.

1993 • 136 citations

Alterations in particle accumulation and clearance in lungs of rats chronically exposed to diesel exhaust

1987 • 108 citations

Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process

1995 • 101 citations

Mechanisms of pollution‐induced airway disease: in vitro itudies in the upper and lower airways

1997 • 101 citations

Response of rodents to inhaled diluted diesel exhaust: Biochemical and cytological changes in bronchoalveolar lavage fluid and in lung tissue

1988 • 98 citations

Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administration of a renal carcinogen, ferric nitrilotriacetate

1996 • 89 citations

Identification of dinitropyrenes in diesel-exhaust particles Their probable presence as the major mutagens

1983 • 86 citations

Effects of Forced and Spontaneous Exercise on 8-Hydroxydeoxyguanosine Levels in Rat Organs

1998 • 84 citations

An endonuclease activity in human polymorphonuclear neutrophils that removes 8-hydroxyguanine residues from DNA

1991 • 84 citations

Ubiquitous Presence in Mammalian Cells of Enzymatic Activity Specifically Cleaving 8‐Hydroxyguanine‐containing DNA

1992 • 84 citations

Relevance of particle-induced rat lung tumors for assessing lung carcinogenic hazard and human lung cancer risk.

1997 • 79 citations

Synthesis of 2'-deoxy-7,8-dihydro-8-oxoguanosine and 2'-deoxy-7,8-dihydro-8-oxoadenosine and their incorporation into oligomeric DNA

1992 • 78 citations

Identification and quantification of highly mutagenic nitroacetoxypyrenes and nitrohydroxypyrenes in diesel-exhaust particles

1985 • 59 citations

Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage

1998 • 53 citations

Lung tumor induced by long-term inhalation or intratracheal instillation of diesel exhaust particles

1997 • 35 citations

RELATIONSHIPS OF LUNG STRUCTURAL AND FUNCTIONAL CHANGES TO ACCUMULATION OF DIESEL EXHAUST PARTICLES

1988 • 35 citations

Comparative dose-response study on the pulmonary carcinogenicity of 1, 6-dinitropyrene and benzo[a]pyrene in F344 rats

1989 • 34 citations

Multifactorial hamster respiratory carcinogenesis with interdependent effects of cannula-induced mucosal wounding, saline, ferric oxide, benzo[a]pyrene and N-methyl-N-nitrosourea.

1989 • 34 citations

Health Effects Of Exposure To Diesel Exhaust Particles

1987 • 25 citations

Relevance of Particle-Induced Rat Lung Tumors for Assessing Lung Carcinogenic Hazard and Human Lung Cancer Risk

1997 • 14 citations

Response of Rodents to Inhaled Diluted Diesel Exhaust: Biochemical and Cytological Changes in Bronchoalveolar Lavage Fluid and in Lung Tissue

1988 • 12 citations

LUNG CANCER IN RATS FROM PROLONGED EXPOSURE TO HIGH CONCENTRATIONS OF CARBONACEOUS PARTICLES: IMPLICATIONS FOR HUMAN RISK ASSESSMENT

1996 • 8 citations

Studies on the ability of rat lung and liver microsomes to facilitate transfer and metabolism of benzo[a]pyrene from diesel particles

1988 • 7 citations

Alterations in Particle Accumulation and Clearance in Lungs of Rats Chronically Exposed to Diesel Exhaust

1987 • 6 citations

Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats

1989 • 3 citations

Deleted Work

1955 • 0 citations