Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

2012 • 3,329 citations

Ghrelin: Structure and Function

2005 • 2,773 citations

Ghrelin Enhances Appetite and Increases Food Intake in Humans

2001 • 2,330 citations

Annual Deaths Attributable to Obesity in the United States

1999 • 1,924 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

Epidemiologic and economic consequences of the global epidemics of obesity and diabetes

2006 • 883 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT

2002 • 734 citations

Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure

2002 • 676 citations

Deletion of Ghrelin Impairs neither Growth nor Appetite

2003 • 631 citations

Mice lacking ghrelin receptors resist the development of diet-induced obesity

2005 • 621 citations

Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats

2001 • 617 citations

Elevated plasma ghrelin levels in Prader–Willi syndrome

2002 • 604 citations

Sleeve Gastrectomy and Gastric Banding: Effects on Plasma Ghrelin Levels

2005 • 565 citations

Structure−Function Studies on the New Growth Hormone-Releasing Peptide, Ghrelin: Minimal Sequence of Ghrelin Necessary for Activation of Growth Hormone Secretagogue Receptor 1a

2000 • 546 citations

Long-Term Impact of Bariatric Surgery on Body Weight, Comorbidities, and Nutritional Status

2006 • 428 citations

Effects of Roux-en-Y Gastric Bypass Surgery on Fasting and Postprandial Concentrations of Plasma Ghrelin, Peptide YY, and Insulin

2005 • 424 citations

Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor

2003 • 417 citations

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

2002 • 394 citations

Ghrelin increases food intake in obese as well as lean subjects

2005 • 378 citations

Des-Acyl Ghrelin Induces Food Intake by a Mechanism Independent of the Growth Hormone Secretagogue Receptor

2006 • 371 citations

Absence of ghrelin protects against early-onset obesity

2005 • 370 citations

Novel Expression and Functional Role of Ghrelin in Rat Testis

2002 • 344 citations

Kidney produces a novel acylated peptide, ghrelin

2000 • 336 citations

Gastrointestinal Satiety Signals

2007 • 323 citations

Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake

2004 • 306 citations

Ghrelin Degradation by Serum and Tissue Homogenates: Identification of the Cleavage Sites

2004 • 300 citations

Ghrelin Stimulates, Whereas Des-Octanoyl Ghrelin Inhibits, Glucose Output by Primary Hepatocytes

2005 • 294 citations

Differential Effects of Gastric Bypass and Banding on Circulating Gut Hormone and Leptin Levels

2006 • 243 citations

Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance

2006 • 242 citations

Vaccination against weight gain

2006 • 224 citations

Small-Molecule Ghrelin Receptor Antagonists Improve Glucose Tolerance, Suppress Appetite, and Promote Weight Loss

2007 • 219 citations

Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor

2004 • 203 citations

Ghrelin: a Gut-Brain Hormone: Effect of Gastric Bypass Surgery

2003 • 202 citations

Changes of Body Weight and Plasma Ghrelin Levels after Gastric Banding and Gastric Bypass

2004 • 194 citations

Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin

2003 • 182 citations

Different Plasma Ghrelin Levels after Laparoscopic Gastric Bypass and Adjustable Gastric Banding in Morbid Obese Subjects

2003 • 170 citations

The Decrease in Plasma Ghrelin Concentrations following Bariatric Surgery Depends on the Functional Integrity of the Fundus

2004 • 165 citations

Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats

2003 • 161 citations

Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity

2007 • 150 citations

Ghrelin Can Bind to a Species of High Density Lipoprotein Associated with Paraoxonase

2003 • 149 citations

Transgenic Mice Overexpressing Des-Acyl Ghrelin Show Small Phenotype

2004 • 147 citations

Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice

2005 • 141 citations

Serum Ghrelin Levels in Response to Glucose Load in Obese Subjects Post‐Gastric Bypass Surgery

2003 • 132 citations

Fasting Plasma Ghrelin Concentrations 6 Months after Gastric Bypass are not Determined by Weight Loss or Changes in Insulinemia

2004 • 131 citations

The Effects of Gastric Surgery on Systemic Ghrelin Levels in the Morbidly Obese

2004 • 130 citations

Early Changes in Ghrelin following Roux-en-Y Gastric Bypass: Influence of Vagal Nerve Functionality?

2007 • 115 citations

Ghrelin Interacts with Human Plasma Lipoproteins

2007 • 114 citations

Energy Homeostasis and Gastric Emptying in Ghrelin Knockout Mice

2005 • 113 citations

Elevated Umbilical Cord Ghrelin Concentrations in Small for Gestational Age Neonates

2003 • 112 citations

Short‐Term Effects of Gastric Bypass Surgery on Circulating Ghrelin Levels

2004 • 111 citations

Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors

2007 • 107 citations

Postoperative Ghrelin Levels and Delayed Recovery from Body Weight Loss after Distal or Total Gastrectomy

2005 • 99 citations

Synthesis and Pharmacological in Vitro and in Vivo Evaluations of Novel Triazole Derivatives as Ligands of the Ghrelin Receptor. 1

2007 • 85 citations

Surgical Approaches to Obesity

2006 • 77 citations

Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)

2007 • 75 citations

Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions

2007 • 71 citations

Intracisternal des-acyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats.

2005 • 68 citations

Ghrelin and the Endocrine Pancreas

2003 • 57 citations

Plasma Ghrelin and Resistin Concentrations Are Suppressed in Infants of Insulin-Dependent Diabetic Mothers

2004 • 54 citations

Recent Developments in Ghrelin Receptor Ligands

2007 • 54 citations

Changes in serum ghrelin predict weight loss after Roux-en-Y gastric bypass in rats

2005 • 45 citations

2,4-Diaminopyrimidine Derivatives as Potent Growth Hormone Secretagogue Receptor Antagonists

2006 • 44 citations

Hypotensive effect of des-acyl ghrelin at nucleus tractus solitarii of rat

2005 • 44 citations

Assessment of ghrelin.

2003 • 35 citations

Anti-Idiotypic Antibody Mimics Proteolytic Function of Parent Antigen

2007 • 32 citations

Cholinesterase-like catalytic antibodies: reaction with substrates and inhibitors

2000 • 24 citations

Antibody catalysis: Completing the circle

2002 • 22 citations

Targeting the Ghrelin Receptor: Orally Active GHS and Cortistatin Analogs

2003 • 20 citations

Active Immunization with a Glycolipid Transition State Analogue Protects against Endotoxic Shock

2002 • 10 citations

A class of 4-aza-lithocholic acid-derived haptens for the generation of catalytic antibodies with steroid synthase capabilities

2000 • 9 citations

The Promise of Ghrelin Antagonism in Obesity Treatment

2006 • 7 citations

Obesity: surgical management

2007 • 2 citations

Making enzymes.

1996 • 1 citations